Nicholas G. Brown

University of North Carolina at Chapel Hill

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 49 papers. Top paper: “Quantifying the heterogeneity of macromolecular machines by mass photometry”.

Quantifying the heterogeneity of macromolecular machines by mass photometry

Nature Communications(2020)10.1038/s41467-020-15642-w

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0DataRank · unranked

232 citations

Katarina Belačić, Tatyana Bodrug, Gavin Young, Ryan T. VanderLinden, Brenda A. Schulman +12 more

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding

Nucleic Acids Research(2020)10.1093/nar/gkaa544

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0DataRank · unranked

130 citations

Dennis Goldfarb, Katarzyna M. Kedziora, Emily Cousins, Gavin D. Grant, Cathy J. Spangler +8 more

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

PLoS Biology(2020)10.1371/journal.pbio.3000975

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0DataRank · unranked

21 citations

Raquel C. Martinez‐Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury +13 more

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.09.033621

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0DataRank · unranked

1 citations

Raquel C. Martinez‐Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury +11 more

Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation

Frontiers in Cell and Developmental Biology(2021)10.3389/fcell.2021.687515

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0DataRank · unranked

27 citations

Kaeli A. Welsh, Megan Hinkle, Michael J. Emanuele, Nicholas G. Brown, Tatyana Bodrug

APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain

Molecular Cell(2021)10.1016/j.molcel.2021.11.031

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0DataRank · unranked

19 citations

Olivia Urso, Tatyana Bodrug, Brandon M. Gassaway, Edmond R. Watson, J. Rajan Prabu +16 more

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

The EMBO Journal(2021)10.15252/embj.2021108823

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0DataRank · unranked

15 citations

Derek L. Bolhuis, Anneroos E Nederstigt, Joshua A. Boyer, Brenda Temple, Thomas Bonacci +9 more

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.23.441013

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0DataRank · unranked

4 citations

Wayne Stallaert, Elizaveta T. Wick, Peter Ngoi, Seth M. Rubin, Nicholas G. Brown +3 more

Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM

Structure(2022)10.1016/j.str.2022.11.014

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65 citations

Demian Keihsler, Tatyana Bodrug, Nicholas G. Brown, David Haselbach, Sascha Josef Amann

Cryo-EM structure of the plant 26S proteasome

Plant Communications(2022)10.1016/j.xplc.2022.100310

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16 citations

Irina Grishkovskaya, Katarina Belačić, Derek L. Bolhuis, Sascha Josef Amann, Brent Foster +9 more

Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex

Journal of Virology(2022)10.1128/jvi.00826-22

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0DataRank · unranked

6 citations

Colton J. Treadway, Zhijun Li, Nathan I. Nicely, Zhizhong Ren, Albert S. Baldwin +4 more

Cryo-EM structure of the chain-elongating E3 ligase UBR5

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.03.515015

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0DataRank · unranked

3 citations

Irina Grishkovskaya, Hanna L. Brunner, Derek L. Bolhuis, Katarina Belačić, Alexander Schleiffer +4 more

Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

The EMBO Journal(2023)10.15252/embj.2022113348

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47 citations

Irina Grishkovskaya, Hanna L. Brunner, Derek L. Bolhuis, Katarina Belačić, Alexander Schleiffer +4 more

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase

Journal of the American Chemical Society(2023)10.1021/jacs.2c11294

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0DataRank · unranked

31 citations

Jarrett M. Pelton, Elizaveta T. Wick, Derek L. Bolhuis, Albert S. Baldwin, Michael J. Emanuele +3 more

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

Cancers(2023)10.3390/cancers15020517

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0DataRank · unranked

26 citations

Derek L. Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang +4 more

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

Nature Structural & Molecular Biology(2023)10.1038/s41594-023-01105-5

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0DataRank · unranked

18 citations

Kaeli A. Welsh, Derek L. Bolhuis, Ethan Paulаkonis, Raquel C. Martinez‐Chacin, Bei Liu +16 more

The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment

Developmental Cell(2023)10.1016/j.devcel.2023.10.002

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0DataRank · unranked

11 citations

Brandon M. Gassaway, Jonathan Tawil, Olivia Urso, Donald Pizzo, Kaeli A. Welsh +7 more

Recruitment of FBXO22 for Targeted Degradation of NSD2

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.01.564830

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0DataRank · unranked

4 citations

John R. Tabor, Jianping Li, Maria Kutera, Jonathan St‐Germain, Ronan P. Hanley +22 more

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.11.561963

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0DataRank · unranked

1 citations

Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang, Christine A. Mills +8 more

Multi-monoubiquitination controls VASP-mediated actin dynamics

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.16.549237

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0DataRank · unranked

0 citations

Cristian Suarez, Laura E. Herring, Kevin S. Cannon, David R. Kovar, Nicholas G. Brown +2 more

Recruitment of FBXO22 for targeted degradation of NSD2

Nature Chemical Biology(2024)10.1038/s41589-024-01660-y

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0DataRank · unranked

59 citations

John R. Tabor, Jianping Li, Maria Kutera, Jonathan St‐Germain, Ronan P. Hanley +24 more

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Biochemical Society Transactions(2024)10.1042/bst20230454

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0DataRank · unranked

12 citations

Michael J. Emanuele, Nicholas G. Brown, Derek L. Bolhuis

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

Cell Reports(2024)10.1016/j.celrep.2024.114510

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0DataRank · unranked

12 citations

Kimberly Lukasik, Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang +10 more

Multi-monoubiquitylation controls VASP-mediated actin dynamics

Journal of Cell Science(2024)10.1242/jcs.261527

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0DataRank · unranked

15 citations

Cristian Suarez, Laura E. Herring, Kevin S. Cannon, David R. Kovar, Nicholas G. Brown +2 more

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Nature Communications(2024)10.1038/s41467-024-46644-7

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7 citations

Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie +18 more

Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation

ACS Chemical Biology(2024)10.1021/acschembio.3c00619

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0DataRank · unranked

10 citations

Joshua A. Boyer, Shiyue Yang, Hui Yang, Mengxi Liu, Zhijun Li +8 more

Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates

UNC Libraries(2024)10.17615/wx15-j073

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9 citations

Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci, Aussie Suzuki, Jeanette Gowen Cook +2 more

Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1

UNC Libraries(2024)10.17615/k601-kt77

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0DataRank · unranked

1 citations

Kaeli A. Welsh, Raquel C. Martinez‐Chacin, Nicholas G. Brown, Tatyana Bodrug, Liying Cui +2 more

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.28.596309

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0DataRank · unranked

1 citations

Derek L. Bolhuis, Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

UNC Libraries(2024)10.17615/3djv-bv96

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0DataRank · unranked

0 citations

Wayne Stallaert, Taylor P. Enrico, Jeremy E. Purvis, Nicholas G. Brown, Seth M. Rubin +4 more

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

UNC Libraries(2024)10.17615/cr0z-4y62

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0DataRank · unranked

0 citations

Charles D. Schwieters, Rolf E. Swenson, V. Keith Hughitt, Raj Chari, Venkata R. Sabbasani +18 more

APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain

UNC Libraries(2024)10.17615/65fs-db82

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0DataRank · unranked

0 citations

Raquel C. Martinez‐Chacin, Nicholas G. Brown, Steven P. Gygi, Robert N. Jinks, Pablo Lara-González +16 more

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

UNC Libraries(2024)10.17615/sqdv-t262

N/A

0DataRank · unranked

0 citations

Michael J. Emanuele, Nicholas G. Brown, Derek L. Bolhuis

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

UNC Libraries(2024)10.17615/s94d-5j87

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0DataRank · unranked

0 citations

Brenda Temple, Joshua P. Steimel, Li H. Gu, Anneroos E Nederstigt, Nicholas G. Brown +9 more

Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation

UNC Libraries(2024)10.17615/xfke-wz53

N/A

0DataRank · unranked

0 citations

Nicholas G. Brown, Michael J. Emanuele, Tatyana Bodrug, Megan Hinkle, Kaeli A. Welsh

Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20

UNC Libraries(2024)10.17615/sjqr-7680

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0DataRank · unranked

0 citations

Joao A. Paulo, Randall W. King, Katharine L. Sackton, Masaya Yamaguchi, Katherine V. Richeson +4 more

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

UNC Libraries(2024)10.17615/5fdn-2z74

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0DataRank · unranked

0 citations

Tatyana Bodrug, Morgan E. Gibbs, Jan‐Michael Peters, Michael J. Emanuele, Jeanette Gowen Cook +10 more

Quantifying the heterogeneity of macromolecular machines by mass photometry

UNC Libraries(2024)10.17615/qf5r-pk96

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0DataRank · unranked

0 citations

Thorsten Friedrich, Adar Sonn-Segev, Nicholas G. Brown, Philipp Kukura, Johannes Schimpf +12 more

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

UNC Libraries(2024)10.17615/jj32-v329

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0DataRank · unranked

0 citations

Derek L. Bolhuis, Xianxi Wang, Ryan D. Mouery, E Drew Toomer, Timothy B. Branigan +10 more

Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex

UNC Libraries(2024)10.17615/vtny-p647

N/A

0DataRank · unranked

0 citations

Yue Xiong, Joseph S. Harrison, Nathan I. Nicely, Elizaveta T. Wick, Zhizhong Ren +4 more

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase

UNC Libraries(2024)10.17615/zv55-rv74

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0DataRank · unranked

0 citations

Sabrina E. Iskandar, Jarrett M. Pelton, Nicholas G. Brown, Elizaveta T. Wick, Michael J. Emanuele +3 more

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

Nature(2025)10.1038/s41586-025-09328-w

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0DataRank · unranked

10 citations

Derek L. Bolhuis, Hualong Yan, Sudipto Das, Xia Xu, Christina C. Abbate +8 more

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

Nature Communications(2025)10.1038/s41467-025-59770-7

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0DataRank · unranked

5 citations

Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook +3 more

Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110288

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0DataRank · unranked

2 citations

Derek L. Bolhuis, Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci

Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation

UNC Libraries(2025)10.17615/71a4-yx54

N/A

0DataRank · unranked

0 citations

Albert S. Baldwin, Mengxi Liu, Joshua A. Boyer, Zhijun Li, Shiyue Yang +8 more

Multi-monoubiquitination controls VASP-mediated actin dynamics

UNC Libraries(2025)10.17615/by1z-vr43

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0DataRank · unranked

0 citations

Stephanie L. Gupton, Laura E. McCormick, Laura E. Herring, Nicholas G. Brown, Kevin S. Cannon +2 more

Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response

Cell chemical biology(2025)10.1016/j.chembiol.2025.11.007

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0DataRank · unranked

0 citations

Li H. Gu, Anneroos E Nederstigt, Logan J. Cope, Derek L. Bolhuis, Kim Harvey +19 more

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

eLife(2025)10.7554/elife.109145

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0DataRank · unranked

0 citations

Michael Almeida, Kyle Pellegrino, Carli K. Opland, J Ethan Paulakonis, Jake McGillion-Moore +9 more

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

eLife(2025)10.7554/elife.109145.1

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0DataRank · unranked

0 citations

Michael Almeida, Kyle Pellegrino, Carli K. Opland, J Ethan Paulakonis, Jake McGillion-Moore +9 more