Brian S. J. Blagg

Biochemistry, Genetics and Molecular BiologyComputer ScienceMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 45 papers. Top paper: “Hsp90 pan and Isoform-Selective Inhibitors as Sensitizers for Cancer Immunotherapy”.

Hsp90 pan and Isoform-Selective Inhibitors as Sensitizers for Cancer Immunotherapy

Pharmaceuticals(2025)10.3390/ph18071025

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0.327DataRank · unranked

7 citations

Neeraj Maurya, Brian S. J. Blagg, Xin Lü, S. Jia

RETRACTED: Novel C‐terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self‐renewal, and epithelial–mesenchymal transition

Molecular Oncology(2020)10.1002/1878-0261.12686

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19 citations

Patrick T. Grogan, Ton Wang, Joseph Bazzill, Ang Zuo, Peter White +6 more

A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro

Surgery(2020)10.1016/j.surg.2020.06.009

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13 citations

Rebecca M. Gorney, Ton Wang, Derek Ge, Nina Zhang, Ang Zuo +3 more

Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

Journal of Thrombosis and Haemostasis(2020)10.1111/jth.14758

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11 citations

Génesis M. Rivera-Márquez, Kristin Beebe, Andy D. Tran, Jane B. Trepel, Jason E. Gestwicki +4 more

Assay design and development strategies for finding Hsp90 inhibitors and their role in human diseases

Pharmacology & Therapeutics(2020)10.1016/j.pharmthera.2020.107747

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36 citations

Ishita Hatial, Bradley M. Keegan, Brian S. J. Blagg, Monimoy Banerjee

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

International Journal of Molecular Sciences(2020)10.3390/ijms21186898

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35 citations

Martina Durcik, Bradley M. Keegan, Darja Gramec Skledar, Živa Zajec, Brian S. J. Blagg +2 more

Natural products and other inhibitors of F1FO ATP synthase

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112779

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32 citations

Terin D’Amico, Brian S. J. Blagg, Bhargav A. Patel

Polymerase Theta Inhibition Kills Homologous Recombination Deficient Tumors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.23.111658

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17 citations

Camille Gelot, Constantia Pantelidou, Adam Y. Li, Hatice Yücel, Rachel E. Davis +9 more

The heat shock response and small molecule regulators

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113846

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103 citations

Cormac M. Huyen, J. H. Kelly, Brian S. J. Blagg, Margaret K. Kurop

The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.0c01700

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0DataRank · unranked

76 citations

Weiya Liu, Kristin Beebe, Monimoy Banerjee, Caitlin N. Kent, Vitumbiko Munthali +6 more

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.22.440982

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4 citations

Syed Z. Saad, Kanagaraj Subramanian, Abigail Cross, Aisha al-Motawa, Kunal Garg +7 more

Inhibiting Spinal Cord-Specific Hsp90 Isoforms Reveals a Novel Strategy to Improve the Therapeutic Index of Opioid Treatment

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.14.439852

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2 citations

Christopher S. Campbell, Kerry Chou, Parthasaradhireddy Tanguturi, Paul Bejarano, Katherin Gabriel +8 more

Recent advances toward the development of Hsp90 C-terminal inhibitors

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.129111

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39 citations

Brian S. J. Blagg, Eva Amatya

The biology and inhibition of glucose‐regulated protein 94/gp96

Medicinal Research Reviews(2022)10.1002/med.21915

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28 citations

Marim Alnaed, Christopher M. Brackett, Brian S. J. Blagg, Kyler W. Pugh

A Split Renilla Luciferase Complementation Assay for the Evaluation of Hsp90/Aha1 Complex Disruptors and Their Activity at the Aha1 C-Terminal Domain

ACS Chemical Biology(2022)10.1021/acschembio.2c00854

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5 citations

Brian S. J. Blagg, Bradley M. Keegan

Synthesis and evaluation of 3′- and 4′-substituted cyclohexyl noviomimetics that modulate mitochondrial respiration

Bioorganic & Medicinal Chemistry(2022)10.1016/j.bmc.2022.116940

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5 citations

Eva Amatya, Sukhmanjit Kaur, Monimoy Banerjee, Ang Zuo, Rick T. Dobrowsky +2 more

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.16.496505

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1 citations

Yun Zhao, Jiling Wen, Sheng Liu, Tianhe Huang, Ishita Hatial +17 more

Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer

Science Immunology(2023)10.1126/sciimmunol.ade4656

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32 citations

Yun Zhao, Jiling Wen, Sheng Liu, Tianhe Huang, Ishita Hatial +17 more

Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer

iScience(2023)10.1016/j.isci.2023.108308

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0DataRank · unranked

19 citations

Vincent M. Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A. Serwetnyk, Taoufik Llbiyi +15 more

Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115531

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17 citations

Shuxia Peng, Bradley M. Keegan, Vincent M. Crowley, Christopher M. Brackett, Andrew Gutierrez +8 more

Enniatin A Analogues as Novel Hsp90 Inhibitors that Modulate Triple-Negative Breast Cancer

ACS Medicinal Chemistry Letters(2023)10.1021/acsmedchemlett.3c00423

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5 citations

Vincent M. Crowley, Christopher M. Brackett, Trever R. Carter, Asif Elahi, Vamsi Krishna Kommalapati +3 more

Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target

Frontiers in Aging Neuroscience(2023)10.3389/fnagi.2023.1282855

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2 citations

Dongwei Hui, Heather Menchen, Huiping Zhao, Olivier Mozziconacci, Heather Wilkins +6 more

CryoEM Structure with ATP Synthase Enables Late‐Stage Diversification of Cruentaren A

Chemistry - A European Journal(2023)10.1002/chem.202300262

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0DataRank · unranked

0 citations

Hui Guo, Terin D’Amico, Leah Abdallah, Chitra Subramanian, Bhargav A. Patel +4 more

Extracellular heat shock protein 90 alpha (eHsp90α)'s role in cancer progression and the development of therapeutic strategies

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116736

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24 citations

Brian S. J. Blagg, Tyelor S. Reynolds

Investigation of the site 2 pocket of Grp94 with KUNG65 benzamide derivatives

Bioorganic & Medicinal Chemistry Letters(2024)10.1016/j.bmcl.2024.129893

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10 citations

Hao Xu, Brian S. J. Blagg, Kyler W. Pugh

The Investigation of Hsp90C‐Terminal Inhibitors Containing Amide Bioisosteres

ChemMedChem(2024)10.1002/cmdc.202400418

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2 citations

Chitra Subramanian, Reagan Long, Kelli McNamara, Mark S. Cohen, Brian S. J. Blagg +1 more

Development of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activities

RSC Medicinal Chemistry(2024)10.1039/d3md00529a

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0DataRank · unranked

7 citations

Chitra Subramanian, Mark S. Cohen, Brian S. J. Blagg, Eva Amatya

Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies

JCI Insight(2024)10.1172/jci.insight.179525

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2 citations

Adele B. Correia, Kylie J. Schache, M. Camila Fernández Zapata, Koralege C. Pathmasiri, Varshasnata Mohanty +12 more

The role of Aha1 in cancer and neurodegeneration

Frontiers in Molecular Neuroscience(2024)10.3389/fnmol.2024.1509280

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2 citations

Kevin Catalfano, Brian S. J. Blagg

Molecular determinants of phospholipid treatment to reduce intracellular cholesterol accumulation in NPC1 deficiency

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107889

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0DataRank · unranked

1 citations

T Liu, Olga Ilnytska, Tamara Allada, Angelina Fomina, Nancy Lin +8 more

Engineered Age-Mimetic Breast Cancer Models Reveal Differential Drug Responses in Young and Aged Microenvironments

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.06.616903

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0DataRank · unranked

0 citations

Lauren Hawthorne, Sharon Stack, Brian S. J. Blagg, Aktar Ali, Pınar Zorlutuna +1 more

Optimization of an Hsp90β-selective inhibitor via exploration of the Hsp90 N-terminal ATP-binding pocket

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117925

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0DataRank · unranked

9 citations

Taddäus Strunden, Ian Mersich, Deborah Barlow, Terin D’Amico, Sanket J. Mishra +4 more

Glucose-regulated protein 94 (Grp94/gp96) in viral pathogenesis: Insights into its role and therapeutic potentials

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117713

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0DataRank · unranked

8 citations

Brian S. J. Blagg, Hao Xu

Proteomic Analysis of Hsp90β-Selective Inhibitors Against Triple-Negative Breast Cancer to Gain a Mechanistic Insight

Molecular & Cellular Proteomics(2025)10.1016/j.mcpro.2025.101043

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8 citations

Daniel D. Hu, Simon D. Weaver, Emma C Ronck, Sanket J. Mishra, Matthew M. Champion +2 more

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews(2025)10.1002/med.22114

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11 citations

Terin D’Amico, Brian S. J. Blagg, Subhabrata Chaudhury

Assessment of Hsp90β-selective inhibitor safety and on-target effects

Scientific Reports(2025)10.1038/s41598-025-86647-y

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10 citations

Sanket J. Mishra, Brian S. J. Blagg, Tyelor S. Reynolds

TRAP1 and its therapeutic potential

Bioorganic & Medicinal Chemistry Letters(2025)10.1016/j.bmcl.2025.130395

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5 citations

Jason Archdeacon, Brian S. J. Blagg, Andrew Gutierrez

Integrative Multi-Omics Analyses Reveal Mechanisms of Resistance to Hsp90β-Selective Inhibition

Cancers(2025)10.3390/cancers17213488

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3 citations

Eahsanul Anik, Aktar Ali, Brian S. J. Blagg, Ian Mersich

Engineered Age‐Mimetic Breast Cancer Models Reveal Differential Drug Responses in Young and Aged Microenvironments

Advanced Healthcare Materials(2025)10.1002/adhm.202404461

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4 citations

Lauren Hawthorne, Sharon Stack, Brian S. J. Blagg, Aktar Ali, Pınar Zorlutuna +1 more

Design, synthesis, and biological properties exhibited by 1,2,3-triazole based Grp94-selective inhibitors

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.118394

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1 citations

Dustin J. E. Huard, E. L. Dunn, Lucas A Chalfoun, Felix Adulley, Raquel L. Lieberman +2 more

Hsp90 β ‐Selective Inhibitors: Probing the Solvent‐Accessible Frontier

ChemMedChem(2025)10.1002/cmdc.202500657

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1 citations

Michael A. Serwetnyk, Xiaozheng Dou, Ian Mersich, Deborah Barlow, Karen L. Houseknecht +4 more

Biotinylated Hsp90β-selective inhibitors

Bioorganic & Medicinal Chemistry Letters(2025)10.1016/j.bmcl.2025.130323

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0 citations

Nitin Sharma, Gaya K Amarasinge, Brian S. J. Blagg, Chaitanya Kondam

[11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics

EJNMMI Radiopharmacy and Chemistry(2025)10.1186/s41181-025-00386-z

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0 citations

Valeria Narykina, Koen Vermeulen, Sanket J. Mishra, Brian S. J. Blagg, Marleen Derweduwe +8 more

The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

Acta Pharmaceutica Sinica B(2020)10.1016/j.apsb.2020.11.015

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0DataRank · unranked

92 citations

Brian S. J. Blagg, Michael A. Serwetnyk

AHA1 regulates Aβ production via modulation of APP expression and γ-secretase assembly

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.03.686106

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0DataRank · unranked

0 citations

Sadequl Islam, Kevin Catalfano, Heather Wilkins, Brian S. J. Blagg, Kun Zou +2 more