Frederick P. Roth

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

6.6Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A reference map of the human binary protein interactome

Nature(2020)10.1038/s41586-020-2188-x

Top 4%

5.4DataRank

Top 4%1333 citations

Dae‐Kyum Kim, L. Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian +83 more

Papers

Driven by 44 papers — median percentile 74. Top paper: “A reference map of the human binary protein interactome”.

A reference map of the human binary protein interactome

Nature(2020)10.1038/s41586-020-2188-x

Top 4%

5.4DataRank

Top 4%1333 citations

Dae‐Kyum Kim, L. Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian +83 more

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

eLife(2020)10.7554/elife.58026

N/A

2.2DataRank · unranked

103 citations

Nathan Rollins, Jason J. Stephany, Katherine A. Sitko, Kenneth A. Matreyek, Marta Verby +7 more

Next-generation large-scale binary protein interaction network for Drosophila melanogaster

Nature Communications(2023)10.1038/s41467-023-37876-0

Top 26%

0.764DataRank

Top 26%44 citations

Kerstin Spirohn, Yanhui Hu, Tong Hao, I. Kovács, Yue Gao +38 more

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2 -LQTS Variant Classification and Cardiac Event Risk Stratification

Circulation(2024)10.1161/circulationaha.124.069828

N/A

0.553DataRank · unranked

39 citations

Chai‐Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo +37 more

Guidelines for releasing a variant effect predictor

Genome biology(2025)10.1186/s13059-025-03572-z

N/A

0.500DataRank · unranked

27 citations

Mihaly Badonyi, Mafalda Dias, Jonathan Frazer, Sushant Kumar, Kresten Lindorff‐Larsen +13 more

Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest

Circulation Genomic and Precision Medicine(2023)10.1161/circgen.122.003792

N/A

0.406DataRank · unranked

14 citations

Jochen Weile, Prince J. Kannankeril, Andrew M. Glazer, Chloe Reuter, Calum A. MacRae +5 more

Understanding genetic variants in context

eLife(2024)10.7554/elife.88231

N/A

0.403DataRank · unranked

10 citations

Stanley Fields, Frederick P. Roth, Lea M. Starita, Cole Trapnell, Judit Villén +3 more

Binary interactome models of inner- versus outer-complexome organisation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.16.435663

Top 48%

0.370DataRank

Top 48%9 citations

Anupama Yadav, Yang Wang, Alice Desbuleux, Dae‐Kyum Kim, Tiziana M. Cafarelli +34 more

MaveRegistry: a collaboration platform for multiplexed assays of variant effect

Bioinformatics(2021)10.1093/bioinformatics/btab215

N/A

0DataRank · unranked

27 citations

Jochen Weile, Nishka Kishore, Maria Nguyen, Alan F. Rubin, Stanley Fields +3 more

Seeds of their own destruction: Dominant-negative peptide screening yields functional insight and therapeutic leads

Cell Systems(2021)10.1016/j.cels.2021.06.003

N/A

0DataRank · unranked

7 citations

Frederick P. Roth, Andrew Savinov

A systematic genotype-phenotype map for missense variants in the human intellectual disability-associated gene GDI1

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.06.463360

N/A

0DataRank · unranked

10 citations

Song Sun, Marta Verby, Jochen Weile, Yingzhou Wu, Marinella Gebbia +4 more

Empowering rare variant burden-based gene-trait association studies via optimized computational predictor choice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.20.459182

N/A

0DataRank · unranked

1 citations

Roujia Li, Yingzhou Wu, Jochen Weile, Robert A. Hegele, Frederick P. Roth +1 more

satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.25.489390

N/A

0DataRank · unranked

1 citations

Song Sun, Atina G. Coté, Frederick P. Roth, Can Cenik, Ian Hoskins

Next-generation large-scale binary protein interaction network for Drosophila

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.02.502359

N/A

0DataRank · unranked

0 citations

Kerstin Spirohn, Yanhui Hu, Tong Hao, I. Kovács, Yue Gao +35 more

Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation

The American Journal of Human Genetics(2023)10.1016/j.ajhg.2023.08.012

N/A

0DataRank · unranked

33 citations

Shahin Sowlati‐Hashjin, Jochen Weile, Rayna Hamilton, Aditya Chawla, Dayag Sheykhkarimli +20 more

Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

Molecular Cell(2023)10.1016/j.molcel.2023.06.025

N/A

0DataRank · unranked

19 citations

Daniel Tabet, Diana Rubio-Contreras, Linjiang Lao, Arne Nedergaard Kousholt, Jochen Weile +12 more

satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

Genome biology(2023)10.1186/s13059-023-02922-z

N/A

0DataRank · unranked

4 citations

Song Sun, Atina G. Coté, Frederick P. Roth, Can Cenik, Ian Hoskins

Pervasive mislocalization of pathogenic coding variants underlying human disorders

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.05.556368

N/A

0DataRank · unranked

9 citations

Marzieh Haghighi, Shahan Haider, Zhen‐Yuan Lin, Dmitri Segal, Chloe Reno +18 more

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.24.542036

N/A

0DataRank · unranked

7 citations

Thea K. Schulze, Matteo Cagiada, Amelie Stein, Frederick P. Roth, Kresten Lindorff‐Larsen +2 more

Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.06.527353

N/A

0DataRank · unranked

4 citations

Shahin Sowlati‐Hashjin, Jochen Weile, Rayna Hamilton, Aditya Chawla, Marinella Gebbia +19 more

Minimum information and guidelines for reporting a Multiplexed Assay of Variant Effect

arXiv (Cornell University)(2023)10.48550/arxiv.2306.15113

N/A

0DataRank · unranked

2 citations

Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth +9 more

Workshop report: the clinical application of data from multiplex assays of variant effect (MAVEs), 12 July 2023

European Journal of Human Genetics(2024)10.1038/s41431-024-01566-2

N/A

0DataRank · unranked

22 citations

Alice Garrett, Lara A. Muffley, Shawn Fayer, Julia Foreman, David J. Adams +7 more

Pacybara: Accurate long-read sequencing for barcoded mutagenized allelic libraries

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.22.529427

N/A

0DataRank · unranked

0 citations

Gabrielle Ferra, Gabriel Boyle, Sriram Pendyala, Clara J. Amorosi, Chiann-Ling C Yeh +9 more

Pervasive mislocalization of pathogenic coding variants underlying human disorders

Cell(2024)10.1016/j.cell.2024.09.003

N/A

0DataRank · unranked

57 citations

Marzieh Haghighi, Shahan Haider, Chloe Reno, Zhen‐Yuan Lin, Dmitri Segal +24 more

Benchmarking computational variant effect predictors by their ability to infer human traits

Genome biology(2024)10.1186/s13059-024-03314-7

N/A

0DataRank · unranked

26 citations

Da Kuang, Megan Lancaster, Roujia Li, Karen Liu, Jochen Weile +6 more

Minimum information and guidelines for reporting a multiplexed assay of variant effect

Genome biology(2024)10.1186/s13059-024-03223-9

N/A

0DataRank · unranked

16 citations

Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth +9 more

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

Genome biology(2024)10.1186/s13059-024-03238-2

N/A

0DataRank · unranked

16 citations

Thea K. Schulze, Matteo Cagiada, Amelie Stein, Frederick P. Roth, Kresten Lindorff‐Larsen +2 more

A missense variant effect map for the human tumor-suppressor protein CHK2

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.10.013

N/A

0DataRank · unranked

15 citations

Daniel Zimmerman, Rosanna Jiang, Maria Nguyen, Jochen Weile, Roujia Li +14 more

Pacybara: accurate long-read sequencing for barcoded mutagenized allelic libraries

Bioinformatics(2024)10.1093/bioinformatics/btae182

N/A

0DataRank · unranked

8 citations

Gabrielle Ferra, Gabriel Boyle, Sriram Pendyala, Clara J. Amorosi, Chiann-Ling C Yeh +9 more

Assessing predictions on fitness effects of missense variants in HMBS in CAGI6

Human Genetics(2024)10.1007/s00439-024-02680-3

N/A

0DataRank · unranked

2 citations

Lisa N. Kinch, Panagiotis Katsonis, Olivier Lichtarge, Milind Jagota, Yun S. Song +26 more

Multiplexed Assays of Variant Effect and Automated Patch-clamping Improve KCNH2 -LQTS Variant Classification and Cardiac Event Risk Stratification

medRxiv(2024)10.1101/2024.02.01.24301443

N/A

0DataRank · unranked

1 citations

Chai‐Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo +37 more

A missense variant effect map for the human tumour suppressor protein CHK2

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.13.579700

N/A

0DataRank · unranked

1 citations

Daniel Zimmerman, Rosanna Jiang, Maria Nguyen, Jochen Weile, Roujia Li +12 more

VEPerform: a web resource for evaluating the performance of variant effect predictors.

PubMed(2024)10.48550/arxiv.2412.10262

N/A

0DataRank · unranked

0 citations

Frederick P. Roth, Cindy Zhang

Landscapes of missense variant impact for human superoxide dismutase 1

The American Journal of Human Genetics(2025)10.1016/j.ajhg.2025.08.019

N/A

0DataRank · unranked

5 citations

M. Ding, Atina G. Coté, Radha Subramaniam, Vignesh Senguttuvan, Haotian Zhang +13 more

Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.14.664734

N/A

0DataRank · unranked

0 citations

Atina G. Coté, Warren van Loggerenberg, Marinella Gebbia, Nishka Kishore, Jochen Weile +19 more

Systematic and proactive evaluation of AIRE missense variant effects

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.18.688830

N/A

0DataRank · unranked

0 citations

Amund Holte Berger, Warren van Loggerenberg, Nishka Kishore, Marinella Gebbia, M. Ding +8 more

Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk

medRxiv(2025)10.64898/2025.12.15.25341924

N/A

0DataRank · unranked

0 citations

Ellen M Osborn, Megan Lancaster, Joseh J. Smith, Qianyi Shen, Temidayo Abe +24 more

A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase

Genome Medicine(2020)10.1186/s13073-020-0711-1

N/A

0DataRank · unranked

80 citations

Jochen Weile, Marta Verby, Yingzhou Wu, Yang Wang, Atina G. Coté +8 more

Systematic analysis of bypass suppression of essential genes

Molecular Systems Biology(2020)10.15252/msb.20209828

N/A

0DataRank · unranked

72 citations

Carles Pons, Guihong Tan, Jason Zi Wang, Jing Hou, Jochen Weile +14 more

Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.014831

N/A

0DataRank · unranked

6 citations

Yeo‐Jin Seo, Myungjin Jo, Hyejin Jeon, Young-Seop Kim, Eun‐Jung Kim +9 more

Yeast-Based Genetic Interaction Analysis of Human Kinome

Cells(2020)10.3390/cells9051156

N/A

0DataRank · unranked

5 citations

Yeo‐Jin Seo, Myungjin Jo, Hyejin Jeon, Won‐Ha Lee, Nozomu Yachie +5 more

MaveQuest: a web resource for planning experimental tests of human variant effects

Bioinformatics(2020)10.1093/bioinformatics/btaa228

N/A

0DataRank · unranked

9 citations

Jochen Weile, Roujia Li, Tom W Ouellette, Jarry A Barber, Frederick P. Roth +1 more

MaveRegistry: a collaboration platform for multiplexed assays of variant effect

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.14.339499

N/A

0DataRank · unranked

6 citations

Jochen Weile, Nishka Kishore, Alan F. Rubin, Stanley Fields, Douglas M. Fowler +2 more

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.10.087312

N/A

0DataRank · unranked

2 citations

Nathan Rollins, Jason J. Stephany, Katherine A. Sitko, Kenneth A. Matreyek, Marta Verby +7 more

Frederick P. Roth

Indexed papers

Top data-sharing exemplar

Papers