Matthew G. Vander Heiden

Also affiliated with Robert Koch Institute, Dana-Farber Cancer Institute, Cancer Research Center, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 66 papers. Top paper: “Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance”.

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

Cancer Research(2019)10.1158/0008-5472.can-19-0960

N/A

4.5DataRank · unranked

169 citations

Mark R. Sullivan, Allison N. Lau, Beatrice Grauman-Boss, Helen S. Mueller, Emanuel Kreidl +7 more

Understanding the Warburg Effect in Cancer

Cold Spring Harbor Perspectives in Medicine(2025)10.1101/cshperspect.a041532

N/A

0.978DataRank · unranked

38 citations

Muhammad Bin Munim, Daniel A. Sharygin, Brooke J. Bevis, Matthew G. Vander Heiden, Zhaoqi Li

Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening

Nature Communications(2023)10.1038/s41467-023-43790-2

N/A

0.470DataRank · unranked

22 citations

Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott +21 more

Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate

Genes & Development(2025)10.1101/gad.352316.124

N/A

0.364DataRank · unranked

9 citations

Brian Zhang, Jonah Frazier, Meijuan Chen, Brian T. Do, Sally Padayao +9 more

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

eLife(2020)10.7554/elife.56782

N/A

0DataRank · unranked

84 citations

Zhaoqi Li, Laura V. Danai, Anna M. Westermark, Alicia M. Darnell, Raphaël Ferreira +14 more

A Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up Study

Metabolites(2020)10.3390/metabo10030099

N/A

0DataRank · unranked

22 citations

Ericka M. Ebot, Brian C. Healy, Kathryn M. Wilson, A. Heather Eliassen, Alberto Ascherio +7 more

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

Cancer & Metabolism(2020)10.1186/s40170-020-00232-7

N/A

0DataRank · unranked

19 citations

Paul Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden +4 more

Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division

Nature Communications(2020)10.1038/s41467-020-18769-y

N/A

0DataRank · unranked

38 citations

Georgios Katsikis, Zhaoqi Li, Kiera M. Sapp, Max A. Stockslager, Daniel Lim +5 more

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.08.140558

N/A

0DataRank · unranked

37 citations

Zhaoqi Li, Dan Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do +9 more

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.08.134890

N/A

0DataRank · unranked

5 citations

Brian W. Ji, Purushottam D. Dixit, Evan C. Lien, Konstantine Tchourine, Aaron M. Hosios +7 more

Caloric restriction alters lipid metabolism to contribute to tumor growth inhibition

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.09.984302

N/A

0DataRank · unranked

3 citations

Anna M. Westermark, Zhaoqi Li, Kiera M. Sapp, Matthew G. Vander Heiden, Evan C. Lien

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.09.984237

N/A

0DataRank · unranked

2 citations

Zhaoqi Li, Laura V. Danai, Anna M. Westermark, Alicia M. Darnell, Raphaël Ferreira +14 more

Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.20.347658

N/A

0DataRank · unranked

2 citations

Allison N. Lau, Sharanya Sivanand, Logan Florek, Jeffrey Wyckoff, Melissa C. Skala +2 more

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.03.974980

N/A

0DataRank · unranked

1 citations

Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Alba Luengo +30 more

Cell-programmed nutrient partitioning in the tumour microenvironment

Nature(2021)10.1038/s41586-021-03442-1

N/A

0DataRank · unranked

1018 citations

Matthew Z. Madden, Melissa M. Wolf, Anna Chytil, Jackie E. Bader, Andrew R. Patterson +27 more

The metabolic landscape of RAS-driven cancers from biology to therapy

Nature Cancer(2021)10.1038/s43018-021-00184-x

N/A

0DataRank · unranked

355 citations

Matthew G. Vander Heiden, Frank McCormick, Suman Mukhopadhyay

Fatty acid synthesis is required for breast cancer brain metastasis

Nature Cancer(2021)10.1038/s43018-021-00183-y

N/A

0DataRank · unranked

325 citations

Ahmed Ali, Alba Luengo, David P. Kodack, Amy Deik, Keene L. Abbott +31 more

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Nature Metabolism(2021)10.1038/s42255-021-00486-5

N/A

0DataRank · unranked

106 citations

Alicia M. Darnell, Montana F. Reilly, Tenzin Kunchok, Lena Joesch-Cohen, Daniel W. Rosenberg +6 more

Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells

Nature Communications(2021)10.1038/s41467-021-22490-9

N/A

0DataRank · unranked

92 citations

Ying Huang, Karl R. Clauser, Steffen Rickelt, Allison N. Lau, Steven A. Carr +3 more

Association of Prediagnostic Blood Metabolomics with Prostate Cancer Defined by ERG or PTEN Molecular Subtypes

Cancer Epidemiology Biomarkers & Prevention(2021)10.1158/1055-9965.epi-20-1363

N/A

0DataRank · unranked

8 citations

Cindy Ke Zhou, Clary B. Clish, Kathryn M. Wilson, Claire H. Pernar, Barbra A. Dickerman +9 more

Pancreatic β cells put the glutamine engine in reverse

Cell Metabolism(2021)10.1016/j.cmet.2021.03.010

N/A

0DataRank · unranked

9 citations

Matthew G. Vander Heiden, Evan C. Lien

Differential substrate use in EGF‐ and oncogenic KRAS‐stimulated human mammary epithelial cells

FEBS Journal(2021)10.1111/febs.15858

N/A

0DataRank · unranked

6 citations

Wentao Dong, Keegan Korthauer, Aaron M. Hosios, Sun Jin Moon, Lucas B. Sullivan +12 more

Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer

Cancer Epidemiology Biomarkers & Prevention(2021)10.1158/1055-9965.epi-20-1461

N/A

0DataRank · unranked

4 citations

Giovanni Parmigiani, Edward L. Giovannucci, Eric B. Rimm, Svitlana Tyekucheva, Massimo Loda +6 more

Nucleotide imbalance decouples cell growth from cell proliferation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.06.471399

N/A

0DataRank · unranked

9 citations

Teemu P. Miettinen, Ryan Elbashir, Christopher S. Nabel, Scott R. Manalis, Caroline A. Lewis +2 more

Nucleotide imbalance decouples cell growth from cell proliferation

Nature Cell Biology(2022)10.1038/s41556-022-00965-1

N/A

0DataRank · unranked

220 citations

Teemu P. Miettinen, Ryan Elbashir, Christopher S. Nabel, Alicia M. Darnell, Brian T. Do +4 more

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Nature Metabolism(2022)10.1038/s42255-022-00588-8

N/A

0DataRank · unranked

84 citations

Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine, Evan C. Lien, Aaron M. Hosios +8 more

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity

Nature Communications(2022)10.1038/s41467-022-29730-6

N/A

0DataRank · unranked

36 citations

Yiming Guo, Shiyang He, Meijuan Chen, Fei Ji, Xinyue Zhou +16 more

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Cancer Research(2022)10.1158/0008-5472.can-21-2352

N/A

0DataRank · unranked

22 citations

Daniel R. Schmidt, Julia E. Heyman, James P. O’Brien, Amy C. Liu, William J. Israelsen +19 more

GOT2 consider the tumor microenvironment

Trends in cancer(2022)10.1016/j.trecan.2022.09.004

N/A

0DataRank · unranked

6 citations

Matthew G. Vander Heiden, Brian T. Do

Oncogenic metabolic rewiring independent of proliferative control in human mammary epithelial cells

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.08.486845

N/A

0DataRank · unranked

8 citations

Mark A. Keibler, Sun Jin Moon, Patricia Cho, Nian Liu, Christian Berrios +7 more

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.16.503984

N/A

0DataRank · unranked

6 citations

Peggy P. Hsu, Sidney Y. Vermeulen, Zhishan Wang, Taghreed Hirz, Keene L. Abbott +21 more

Slow TCA flux and ATP production in primary solid tumours but not metastases

Nature(2023)10.1038/s41586-022-05661-6

N/A

0DataRank · unranked

297 citations

Daniel Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa +23 more

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Science(2023)10.1126/science.abm3452

N/A

0DataRank · unranked

157 citations

Ahmad A. Cluntun, Heidi Schubert, Sean R. Hackett, Jordan A. Berg, Paul G. Leonard +41 more

Neurons require glucose uptake and glycolysis in vivo

Cell Reports(2023)10.1016/j.celrep.2023.112335

N/A

0DataRank · unranked

131 citations

Caroline Guglielmetti, Yoshitaka Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields +14 more

Manipulating mitochondrial electron flow enhances tumor immunogenicity

Science(2023)10.1126/science.abq1053

N/A

0DataRank · unranked

115 citations

Siva Karthik Varanasi, Melissa Johnson, Mannix J. Burns, Gladys R. Rojas, Pau B. Esparza‐Moltó +16 more

Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer

Nature Communications(2023)10.1038/s41467-023-40024-3

N/A

0DataRank · unranked

68 citations

Michael H. Rosenthal, Tilak Sundaresan, Natalia Khalaf, Valerie Lee, Lauren K. Brais +20 more

Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids

Cell Reports(2023)10.1016/j.celrep.2023.113539

N/A

0DataRank · unranked

23 citations

Alicia M. Darnell, Kiera M. Sapp, Matthew G. Vander Heiden, Sabrina L. Spencer, Rong Yao

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

Cell chemical biology(2023)10.1016/j.chembiol.2023.08.007

N/A

0DataRank · unranked

31 citations

Ahmed Ali, Dominick Casalena, Brian T. Do, Raphaël Ferreira, Jaime H. Cheah +29 more

Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC

Journal of Thoracic Oncology(2023)10.1016/j.jtho.2023.03.014

N/A

0DataRank · unranked

12 citations

Christopher S. Nabel, Dezhi Li, Ruth Í. O’Connor, Caroline R. Crosby, Sarah Chang +27 more

Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer

Communications Medicine(2023)10.1038/s43856-023-00336-3

N/A

0DataRank · unranked

3 citations

Iva Monique T. Gramatikov, Allison Sheen, Christopher L. Williams, Martina Hurwitz, Laura E. Dodge +15 more

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.25.529972

N/A

0DataRank · unranked

8 citations

Ahmed Ali, Dominick Casalena, Brian T. Do, Raphaël Ferreira, Jaime H. Cheah +25 more

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.28.538590

N/A

0DataRank · unranked

8 citations

Karl A. Merrick, Yi Wen Kong, Anita Izrael-Tomasevic, George Eng, Erika D. Handly +15 more

A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.26.525375

N/A

0DataRank · unranked

7 citations

Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden +2 more

577 Cancer immunotherapy responses persist after lymph node resection

Regular and Young Investigator Award Abstracts(2023)10.1136/jitc-2023-sitc2023.0577

N/A

0DataRank · unranked

0 citations

Meghan J. O’Melia, James W. Baish, Laurel B. Darragh, Pin‐Ji Lei, Lutz Menzel +8 more

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.24.573250

N/A

0DataRank · unranked

0 citations

Ahmed Ali, Bradley I. Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D. Landis +16 more

Why do patients with cancer die?

Nature reviews. Cancer(2024)10.1038/s41568-024-00708-4

N/A

0DataRank · unranked

129 citations

Katy Burke, Thomas R. Cox, Theresa Guise, Mariam Jamal‐Hanjani, Tobias Janowitz +6 more

Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis

Nature Communications(2024)10.1038/s41467-024-45167-5

N/A

0DataRank · unranked

54 citations

Guangan Hu, Zhongqi Fan, Huirui Wang, Yinghui Gao, Sisi Wang +6 more

Unprocessed genomic uracil as a source of DNA replication stress in cancer cells

Molecular Cell(2024)10.1016/j.molcel.2024.04.004

N/A

0DataRank · unranked

40 citations

Christopher S. Nabel, Turner W. Seay, Parasvi S. Patel, Ajinkya S. Kawale, Caroline R. Crosby +7 more

Cancer tissue of origin constrains the growth and metabolism of metastases

Nature Metabolism(2024)10.1038/s42255-024-01105-9

N/A

0DataRank · unranked

34 citations

Yetiş Gültekin, Peter Winter, Sidney Y. Vermeulen, Konstantine Tchourine, Keene L. Abbott +22 more

Effects of Aging on Glucose and Lipid Metabolism in Mice

Aging Cell(2024)10.1111/acel.14462

N/A

0DataRank · unranked

11 citations

Ngoc Vu, Anna M. Westermark, Laura V. Danai, Allison N. Lau, Yetiş Gültekin +4 more

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

eLife(2024)10.7554/elife.95652

N/A

0DataRank · unranked

18 citations

Ahmed Ali, Bradley I. Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D. Landis +16 more

RAD21 promotes oncogenesis and lethal progression of prostate cancer

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2405543121

N/A

0DataRank · unranked

9 citations

Konrad H. Stopsack, Daniel R. Schmidt, Duanduan Ma, Zhe Li, Paul Scheet +13 more

BRAF V600 and ErbB inhibitors directly activate GCN2 in an off-target manner to limit cancer cell proliferation

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.12.19.629301

N/A

0DataRank · unranked

2 citations

Nasreen C. Marikar, Vu Nguyen, Varuna Nangia, Alicia M. Darnell, Matthew G. Vander Heiden +3 more

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

eLife(2024)10.7554/elife.95652.1

N/A

0DataRank · unranked

0 citations

Ahmed Ali, Bradley I. Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D. Landis +16 more

Reviewer #1 (Public Review): Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

(2024)10.7554/elife.95652.2.sa2

N/A

0DataRank · unranked

0 citations

Ahmed Ali, Bradley I. Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D. Landis +16 more

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

eLife(2024)10.7554/elife.95652.3

N/A

0DataRank · unranked

0 citations

Ahmed Ali, Bradley I. Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D. Landis +16 more

Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.28.609894

N/A

0DataRank · unranked

0 citations

Shreya Chaudhary, Annie X Li, S Trojan, Cameron T. Flower, Paula Vo +12 more

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress

Nature Communications(2025)10.1038/s41467-025-60238-x

N/A

0DataRank · unranked

11 citations

Keshan Wang, Mannan Nouri, N. V. Kozlova, Daniel R. Schmidt, Anastasia Stavridi +27 more

SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation

Nature Communications(2025)10.1038/s41467-025-56130-3

N/A

0DataRank · unranked

12 citations

Ju Shi, Sarah Chang, Jason Yang, Samuel Block, Charles H. Adelmann +12 more

Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

Molecular Cell(2025)10.1016/j.molcel.2025.05.007

N/A

0DataRank · unranked

4 citations

Shreya Chaudhary, Annie X Li, S Trojan, Cameron T. Flower, Paula Vo +12 more

Sideroflexins enable mitochondrial transport and metabolism of neutral amino acids

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.18.660357

N/A

0DataRank · unranked

3 citations

Fangtao Chi, Paul C. Rosen, Sergio Sebastian Pineda, Alicia M. Darnell, Keene L. Abbott +5 more

Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.05.668488

N/A

0DataRank · unranked

0 citations

Keene L. Abbott, Rachel Nordgren, Amy Deik, Nupur K. Das, Millenia Waite +14 more

Comparative analysis of plasma and bone marrow nutrient levels in pediatric B-ALL patients

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.05.668707

N/A

0DataRank · unranked

0 citations

Ahmed Ali, Muhammad Bin Munim, Devika P. Bagchi, Tenzin Kunchok, Millenia Waite +8 more

Acetoacetate suppresses colon cancer via an MR1-MAIT axis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.29.685375

N/A

0DataRank · unranked

0 citations

Geniver El Tekle, Edrees H. Rashan, Diogo Fonseca-Pereira, Yern-Hyerk Shin, Natalia Andreeva +13 more

Data from Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

10.1158/0008-5472.c.6511311.v1

N/A

0DataRank · unranked

0 citations

Mark R. Sullivan, Allison N. Lau, Beatrice Grauman-Boss, Helen S. Mueller, Emanuel Kreidl +7 more

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Cancer Discovery(2020)10.1158/2159-8290.cd-19-1228

N/A

0DataRank · unranked

287 citations

Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang +35 more