Aleksander S. Popel

Also affiliated with Johns Hopkins Medicine, AsclepiX Therapeutics (United States), Sidney Kimmel Comprehensive Cancer Center

Biochemistry, Genetics and Molecular BiologyMathematicsMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 59 papers. Top paper: “Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer”.

Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer

Journal for ImmunoTherapy of Cancer(2021)10.1136/jitc-2020-002100

N/A

1.4DataRank · unranked

57 citations

Huilin Ma, Richard J. Sové, Leisha A. Emens, Aleksander S. Popel, Hanwen Wang

Virtual clinical trials of anti-PD-1 and anti-CTLA-4 immunotherapy in advanced hepatocellular carcinoma using a quantitative systems pharmacology model

Journal for ImmunoTherapy of Cancer(2022)10.1136/jitc-2022-005414

N/A

1.2DataRank · unranked

49 citations

Babita K. Verma, Hanwen Wang, Won Jin Ho, Mark Yarchoan, Aleksander S. Popel +1 more

Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response

ImmunoInformatics(2021)10.1016/j.immuno.2021.100002

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0.844DataRank · unranked

31 citations

Chang Gong, Álvaro Ruiz-Martínez, Hanwen Wang, Emily F. Davis-Marcisak, Atul Deshpande +3 more

Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model

Clinical & Experimental Metastasis(2014)10.1007/s10585-013-9610-9

N/A

0.542DataRank · unranked

36 citations

Niranjan B. Pandey, Aleksander S. Popel, Esak Lee

Oxygen diffusive shunts under conditions of heterogeneous oxygen delivery

Journal of Theoretical Biology(1982)10.1016/0022-5193(82)90229-6

N/A

0.470DataRank · unranked

22 citations

Aleksander S. Popel

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling

International Journal of Molecular Sciences(2020)10.3390/ijms21145142

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0DataRank · unranked

20 citations

Raquel Lima e Silva, Zenny Chu, Peter A. Campochiaro, Niranjan B. Pandey, Aleksander S. Popel +1 more

Peptides that immunoactivate the tumor microenvironment

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer(2020)10.1016/j.bbcan.2020.188486

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0DataRank · unranked

39 citations

Aleksander S. Popel, Natsuki Furukawa

Predictive models of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using nuclear morphology and tissue architecture

Cell Reports Medicine(2021)10.1016/j.xcrm.2021.100382

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0DataRank · unranked

46 citations

Trinity J. Bivalacqua, Max Kates, Roland Seiler, Peter C. Black, Aleksander S. Popel +2 more

A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization

iScience(2021)10.1016/j.isci.2021.102112

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0DataRank · unranked

45 citations

Thalyta X. Medeiros, Richard J. Sové, Brian H. Annex, Aleksander S. Popel, Chen Zhao

A Spatial Quantitative Systems Pharmacology Platform spQSP-IO for Simulations of Tumor–Immune Interactions and Effects of Checkpoint Inhibitor Immunotherapy

Cancers(2021)10.3390/cancers13153751

N/A

0DataRank · unranked

38 citations

Álvaro Ruiz-Martínez, Holly Kimko, Aleksander S. Popel, Chang Gong

A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway

npj Systems Biology and Applications(2021)10.1038/s41540-021-00194-6

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0DataRank · unranked

14 citations

Christopher D. Kontos, Brian H. Annex, Aleksander S. Popel, Yu Zhang

Protocol for simulating macrophage signal transduction and phenotype polarization using a large-scale mechanistic computational model

STAR Protocols(2021)10.1016/j.xpro.2021.100739

N/A

0DataRank · unranked

4 citations

Aleksander S. Popel, Chen Zhao

825 High-dimensional image cytometry reveals spatially organized tumor-immune microenvironment in hepatocellular carcinoma

Regular and Young Investigator Award Abstracts(2021)10.1136/jitc-2021-sitc2021.825

N/A

0DataRank · unranked

1 citations

Won Jin Ho, Mark Yarchoan, Aleksander S. Popel, Hao‐Yang Mi

Computational Systems Biology Modeling of the Angiopoietin‐Tie Signaling Pathway and its Crosstalk with α5β1 Integrin in Endothelial Cells

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.02368

N/A

0DataRank · unranked

0 citations

Christopher D. Kontos, Brian H. Annex, Aleksander S. Popel, Yu Zhang

Multi-Scale Spatial Analysis of the Tumor Microenvironment Reveals Features of Cabozantinib and Nivolumab Efficacy in Hepatocellular Carcinoma

Frontiers in Immunology(2022)10.3389/fimmu.2022.892250

N/A

0DataRank · unranked

89 citations

Won Jin Ho, Mark Yarchoan, Aleksander S. Popel, Haoyang Mi

Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers

Cancer Research(2022)10.1158/0008-5472.can-22-1190

N/A

0DataRank · unranked

78 citations

Shamilene Sivagnanam, Courtney B. Betts, Shannon M. Liudahl, Elizabeth M. Jaffee, Lisa M. Coussens +2 more

Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model

PLoS Computational Biology(2022)10.1371/journal.pcbi.1010254

N/A

0DataRank · unranked

61 citations

Chang Gong, Hanwen Wang, Richard J. Sové, Haoyang Mi, Holly Kimko +2 more

Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer

iScience(2022)10.1016/j.isci.2022.104702

N/A

0DataRank · unranked

39 citations

Chen Zhao, Cesar A. Santa‐Maria, Leisha A. Emens, Aleksander S. Popel, Hanwen Wang

The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting

Expert Opinion on Therapeutic Targets(2022)10.1080/14728222.2022.2170779

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0DataRank · unranked

27 citations

Vered Stearns, Cesar A. Santa‐Maria, Aleksander S. Popel, Natsuki Furukawa

Label Cleaning Multiple Instance Learning: Refining Coarse Annotations on Single Whole-Slide Images

IEEE Transactions on Medical Imaging(2022)10.1109/tmi.2022.3202759

N/A

0DataRank · unranked

34 citations

Carla Saoud, Sintawat Wangsiricharoen, Aaron W. James, Aleksander S. Popel, Jeremias Sulam +1 more

Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease

JACC Basic to Translational Science(2022)10.1016/j.jacbts.2021.10.014

N/A

0DataRank · unranked

16 citations

Joshua L. Heuslein, Yu Zhang, Brian H. Annex, Aleksander S. Popel, Chen Zhao

Endothelial Regulation of Microvascular Growth and Stability by Ang‐Tie and VEGF Signaling Pathways: A Mechanistic Computational Systems Biology Model

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r2072

N/A

0DataRank · unranked

1 citations

Christopher D. Kontos, Brian H. Annex, Aleksander S. Popel, Yu Zhang

Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces

Cell Systems(2023)10.1016/j.cels.2023.03.004

N/A

0DataRank · unranked

40 citations

Melanie Loth, Dimitrios N. Sidiropoulos, Shuming Zhang, Long Yuan, Alexander T.F. Bell +25 more

Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition

npj Precision Oncology(2023)10.1038/s41698-023-00405-9

N/A

0DataRank · unranked

33 citations

Theinmozhi Arulraj, Holly Kimko, Aleksander S. Popel, Hanwen Wang

Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager

Frontiers in Pharmacology(2023)10.3389/fphar.2023.1163432

N/A

0DataRank · unranked

33 citations

Hanwen Wang, Yu Zhang, Jun Wang, Minu Pilvankar, Masoud Nickaeen +3 more

A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition

Science Advances(2023)10.1126/sciadv.adg0289

N/A

0DataRank · unranked

29 citations

Hanwen Wang, Leisha A. Emens, Cesar A. Santa‐Maria, Aleksander S. Popel, Theinmozhi Arulraj

Combining Multikinase Tyrosine Kinase Inhibitors Targeting the Vascular Endothelial Growth Factor and Cluster of Differentiation 47 Signaling Pathways Is Predicted to Increase the Efficacy of Antiangiogenic Combination Therapies

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.3c00008

N/A

0DataRank · unranked

18 citations

Aleksander S. Popel, Hojjat Bazzazi, Yu Zhang

Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model

Cancers(2023)10.3390/cancers15102750

N/A

0DataRank · unranked

16 citations

Hao‐Yang Mi, Chang Gong, Holly Kimko, Aleksander S. Popel, Mehdi Nikfar

Anti-angiogenic collagen IV-derived peptide target engagement with αvβ3 and α5β1 in ocular neovascularization models

iScience(2023)10.1016/j.isci.2023.106078

N/A

0DataRank · unranked

14 citations

Adam C. Mirando, Stephany Y. Tzeng, Jordan J. Green, Aleksander S. Popel, Niranjan B. Pandey +2 more

Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells

npj Systems Biology and Applications(2023)10.1038/s41540-023-00308-2

N/A

0DataRank · unranked

14 citations

Youli Wang, Brian H. Annex, Aleksander S. Popel, Min Song

Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model

CPT Pharmacometrics & Systems Pharmacology(2023)10.1002/psp4.13060

N/A

0DataRank · unranked

11 citations

Hanwen Wang, Yu Zhang, Vahideh Vakil, Hojjat Bazzazi, Aleksander S. Popel +1 more

Gel-forming therapeutic peptide exhibits sustained delivery and efficacy in a mouse model of triple-negative breast cancer

Peptides(2023)10.1016/j.peptides.2023.171075

N/A

0DataRank · unranked

2 citations

Adam C. Mirando, Ioanna Liatsou, George Sgouros, Aleksander S. Popel, Niranjan B. Pandey +1 more

Spatial and Compositional Biomarkers in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.18.572234

N/A

0DataRank · unranked

10 citations

Ravi Varadhan, Ashley Cimino‐Mathews, Leisha A. Emens, Cesar A. Santa‐Maria, Aleksander S. Popel +1 more

Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.11.553000

N/A

0DataRank · unranked

6 citations

Atul Deshpande, Babita K. Verma, Hanwen Wang, Hao‐Yang Mi, Long Yuan +9 more

Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth

Research Square(2023)10.21203/rs.3.rs-3335225/v1

N/A

0DataRank · unranked

1 citations

Wendy Yang, Alex Chao, Akash Patil, Adam C. Mirando, Niranjan B. Pandey +2 more

Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.25.538191

N/A

0DataRank · unranked

0 citations

Theinmozhi Arulraj, Holly Kimko, Aleksander S. Popel, Hanwen Wang

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling

npj Digital Medicine(2024)10.1038/s41746-024-01188-4

N/A

0DataRank · unranked

91 citations

Theinmozhi Arulraj, Alberto Ippolito, Aleksander S. Popel, Hanwen Wang

Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery

Cancer Research(2024)10.1158/0008-5472.can-24-0943

N/A

0DataRank · unranked

35 citations

Atul Deshpande, Babita K. Verma, Hanwen Wang, Haoyang Mi, Long Yuan +9 more

Computational methods and biomarker discovery strategies for spatial proteomics: a review in immuno-oncology

Briefings in Bioinformatics(2024)10.1093/bib/bbae421

N/A

0DataRank · unranked

34 citations

Shamilene Sivagnanam, Won Jin Ho, Shuming Zhang, Daniel Bergman, Atul Deshpande +6 more

Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2410911121

N/A

0DataRank · unranked

15 citations

Hanwen Wang, Atul Deshpande, Ravi Varadhan, Leisha A. Emens, Elizabeth M. Jaffee +4 more

Spatial Architecture of Single-Cell and Vasculature in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer

Modern Pathology(2024)10.1016/j.modpat.2024.100652

N/A

0DataRank · unranked

14 citations

Ravi Varadhan, Ashley Cimino‐Mathews, Leisha A. Emens, Cesar A. Santa‐Maria, Aleksander S. Popel +1 more

Virtual clinical trials via a QSP immuno-oncology model to simulate the response to a conditionally activated PD-L1 targeting antibody in NSCLC

Journal of Pharmacokinetics and Pharmacodynamics(2024)10.1007/s10928-024-09928-5

N/A

0DataRank · unranked

11 citations

Hanwen Wang, Yu Zhang, Vahideh Vakil, Aleksander S. Popel, Alberto Ippolito

Leveraging multi-omics data to empower quantitative systems pharmacology in immuno-oncology

Briefings in Bioinformatics(2024)10.1093/bib/bbae131

N/A

0DataRank · unranked

15 citations

Hanwen Wang, Alberto Ippolito, Shuming Zhang, Elana J. Fertig, Aleksander S. Popel +1 more

Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway

Frontiers in Physiology(2024)10.3389/fphys.2024.1351753

N/A

0DataRank · unranked

13 citations

Brian H. Annex, Aleksander S. Popel, Rebeca Hannah de Melo Oliveira

Quantitative systems pharmacology modeling of macrophage‐targeted therapy combined with PD‐L1 inhibition in advanced NSCLC

Clinical and Translational Science(2024)10.1111/cts.13811

N/A

0DataRank · unranked

13 citations

Theinmozhi Arulraj, Samira Anbari, Aleksander S. Popel, Hanwen Wang

Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease

PNAS Nexus(2024)10.1093/pnasnexus/pgae031

N/A

0DataRank · unranked

11 citations

Yuhao Qiang, He Li, Guansheng Li, Lu Lu, Ming Dao +4 more

Identifying biomarkers for treatment of uveal melanoma by T cell engager using a QSP model

npj Systems Biology and Applications(2024)10.1038/s41540-024-00434-5

N/A

0DataRank · unranked

10 citations

Hanwen Wang, Theinmozhi Arulraj, Masoud Nickaeen, Minu Pilvankar, Jun Wang +3 more

Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth

Cell Death Discovery(2024)10.1038/s41420-024-01932-5

N/A

0DataRank · unranked

8 citations

Wendy Yang, Alex Chao, Akash Patil, Adam C. Mirando, Niranjan B. Pandey +2 more

Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer

Frontiers in Physiology(2020)10.3389/fphys.2020.583333

N/A

0DataRank · unranked

79 citations

Chang Gong, Jeremias Sulam, Elana J. Fertig, Alexander S. Szalay, Elizabeth M. Jaffee +5 more

Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns in Breast Multiplexed Digital Pathology

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.22.590118

N/A

0DataRank · unranked

1 citations

Cesar A. Santa‐Maria, Aleksander S. Popel, Jeremias Sulam, Zhenzhen Wang

Bi-level graph learning unveils prognosis-relevant tumor microenvironment patterns in breast multiplexed digital pathology

Patterns(2025)10.1016/j.patter.2025.101178

N/A

0DataRank · unranked

1 citations

Cesar A. Santa‐Maria, Aleksander S. Popel, Jeremias Sulam, Zhenzhen Wang

A mechanistic computational model of HGF-VEGF-mediated endothelial cell proliferation and vascular permeability

iScience(2025)10.1016/j.isci.2025.113199

N/A

0DataRank · unranked

1 citations

Akash Patil, Brian H. Annex, Arvind P. Pathak, Aleksander S. Popel, Rebeca Hannah de Melo Oliveira

Bispecific receptor decoy proteins block ocular neovascularization via simultaneous blockade of vascular endothelial growth factor A and C

Molecular Therapy(2025)10.1016/j.ymthe.2025.03.027

N/A

0DataRank · unranked

2 citations

Emily Ariail, Raquel Lima e Silva, Akash Patil, Mingliang Zhang, Jikui Shen +9 more

Experimental and computational studies of IL-6 signaling in endothelial cells under hypoxia serum starvation conditions

Cytokine(2025)10.1016/j.cyto.2025.157029

N/A

0DataRank · unranked

0 citations

Youli Wang, Brian H. Annex, Aleksander S. Popel, Min Song

Quantitative Systems Pharmacology Modeling in Immuno-Oncology: Hypothesis Testing, Dose Optimization, and Efficacy Prediction

Handbook of experimental pharmacology(2024)10.1007/164_2024_735

N/A

0DataRank · unranked

5 citations

Theinmozhi Arulraj, Alberto Ippolito, Aleksander S. Popel, Hanwen Wang

QSP‐IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno‐Oncology Applications

CPT Pharmacometrics & Systems Pharmacology(2020)10.1002/psp4.12546

N/A

0DataRank · unranked

58 citations

Mohammad Jafarnejad, Chen Zhao, Hanwen Wang, Huilin Ma, Aleksander S. Popel +1 more

Conducting a Virtual Clinical Trial in HER2-Negative Breast Cancer Using a Quantitative Systems Pharmacology Model With an Epigenetic Modulator and Immune Checkpoint Inhibitors

Frontiers in Bioengineering and Biotechnology(2020)10.3389/fbioe.2020.00141

N/A

0DataRank · unranked

52 citations

Richard J. Sové, Mohammad Jafarnejad, Sondra Rahmeh, Elizabeth M. Jaffee, Vered Stearns +4 more

Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model

Journal for ImmunoTherapy of Cancer(2020)10.1136/jitc-2020-001141

N/A

0DataRank · unranked

51 citations

Hanwen Wang, Richard J. Sové, Jun Wang, Craig Giragossian, Aleksander S. Popel +1 more

Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide

OncoImmunology(2020)10.1080/2162402x.2020.1760685

N/A

0DataRank · unranked

20 citations

Akash Patil, Christine I. Rafie, Brian J. Christmas, Niranjan B. Pandey, Vered Stearns +4 more