Nicole Kleinstreuer

National Institute of Environmental Health Sciences

Computer ScienceMaterials ScienceDecision SciencesEnvironmental Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

2.1Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

High-Throughput Screening to Predict Chemical-Assay Interference

Scientific Reports(2020)10.1038/s41598-020-60747-3

Top 13%

1.6DataRank

Top 13%43 citations

Ruili Huang, Srilatha Sakamuru, Menghang Xia, Anton Simeonov, Kamel Mansouri +4 more

Papers

Driven by 54 papers — median percentile 75. Top paper: “High-Throughput Screening to Predict Chemical-Assay Interference”.

High-Throughput Screening to Predict Chemical-Assay Interference

Scientific Reports(2020)10.1038/s41598-020-60747-3

Top 13%

1.6DataRank

Top 13%43 citations

Ruili Huang, Srilatha Sakamuru, Menghang Xia, Anton Simeonov, Kamel Mansouri +4 more

Bringing Big Data to Bear in Environmental Public Health: Challenges and Recommendations

Frontiers in Artificial Intelligence(2020)10.3389/frai.2020.00031

N/A

0.892DataRank · unranked

17 citations

Alexia Akbay, Melpomene Vasiliou, Ronald N. Hines, Lucas Joppa, Vasilis Vasiliou +2 more

A database of human predictive patch test data for skin sensitization

Archives of Toxicology(2023)10.1007/s00204-023-03530-3

Top 37%

0.524DataRank

Top 37%13 citations

Jaleh Abedini, David Allen, John Gordon, Victoria Hull, Nicole Kleinstreuer +7 more

ChemMaps.com v2.0: exploring the environmental chemical universe

Nucleic Acids Research(2023)10.1093/nar/gkad380

N/A

0.402DataRank · unranked

7 citations

Mike Conway, Sue Nolte, Aswani Unnikrishnan, Charles Schmitt, Nicole Kleinstreuer +1 more

STopTox: An In-Silico Alternative to Animal Testing for Acute Systemic and TOPical TOXicity

ChemRxiv(2020)10.26434/chemrxiv.13283930.v1

N/A

0.360DataRank · unranked

10 citations

Vinícius M. Alves, Rodolpho C. Braga, Daniel Korn, Kirsten E. Overdahl, Arthur C. Silva +9 more

The long way from raw data to NAM-based information: Overview on data layers and processing steps

ALTEX(2025)10.14573/altex.2412171

N/A

0.104DataRank · unranked

1 citations

Markus Brüll, Jan G. Hengstler, Daniel R. Dietrich, Andreas Gruber, Michele Dipalo +31 more

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

UNC Libraries(2020)10.17615/x095-3q76

N/A

0DataRank · unranked

0 citations

Carolina Horta Andrade, Eugene Muratov, Vinícius M. Alves, Alexander Tropsha, Denis Fourches +2 more

Large-Scale Modeling of Multispecies Acute Toxicity End Points Using Consensus of Multitask Deep Learning Methods

Journal of Chemical Information and Modeling(2021)10.1021/acs.jcim.0c01164

N/A

0DataRank · unranked

103 citations

Vishal B. Siramshetty, Vinícius M. Alves, Eugene Muratov, Nicole Kleinstreuer, Alexander Tropsha +4 more

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals

Artificial Intelligence in the Life Sciences(2021)10.1016/j.ailsci.2021.100028

N/A

0DataRank · unranked

30 citations

Joyce Villa Verde Bastos Borba, Vinícius M. Alves, Steven U.S. Hall, Nicholas Furnham, Nicole Kleinstreuer +4 more

Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies

Toxicological Sciences(2022)10.1093/toxsci/kfac042

N/A

0DataRank · unranked

60 citations

Kamel Mansouri, Kimberly T. To, Bevin E. Blake, Jeremy Fitzpatrick, Judy Strickland +5 more

Data curation to support toxicity assessments using the Integrated Chemical Environment

Frontiers in Toxicology(2022)10.3389/ftox.2022.987848

N/A

0DataRank · unranked

37 citations

Neepa Choksi, Jaleh Abedini, Shannon Bell, Patricia Ceger, Bethany Cook +6 more

Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Frontiers in Pharmacology(2022)10.3389/fphar.2022.864742

N/A

0DataRank · unranked

30 citations

Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen, Nicole Kleinstreuer +1 more

Application of Defined Approaches for Skin Sensitization to Agrochemical Products

Frontiers in Toxicology(2022)10.3389/ftox.2022.852856

N/A

0DataRank · unranked

29 citations

James Truax, Marco Corvaro, Raja S. Settivari, Joseph E. Henriquez, Jeremy McFadden +7 more

A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target

The Science of The Total Environment(2022)10.1016/j.scitotenv.2022.158905

N/A

0DataRank · unranked

19 citations

Agnes L. Karmaus, Nicole Kleinstreuer, Fred Parham, Cynthia V. Rider, John F. Wambaugh +2 more

Current ecotoxicity testing needs among selected U.S. federal agencies

Regulatory Toxicology and Pharmacology(2022)10.1016/j.yrtph.2022.105195

N/A

0DataRank · unranked

17 citations

Natàlia Garcia-Reyero, David Allen, Elyssa Arnold, Raanan A. Bloom, Jennifer C. Brennan +26 more

PreS/MD: Predictor of Sensitization Hazard for Chemical Substances Released From Medical Devices

Toxicological Sciences(2022)10.1093/toxsci/kfac078

N/A

0DataRank · unranked

10 citations

Joyce Villa Verde Bastos Borba, Rodolpho C. Braga, Daniel Korn, Nicole Kleinstreuer, Kevin Causey +4 more

Computational model for fetal skeletal defects potentially linked to disruption of retinoic acid signaling

Frontiers in Pharmacology(2022)10.3389/fphar.2022.971296

N/A

0DataRank · unranked

13 citations

Bhavesh K. Ahir, Nancy Baker, Nicole Kleinstreuer, Menghang Xia, Thomas B. Knudsen +1 more

Towards replacement of animal tests with in vitro assays: a gene expression biomarker predicts in vitro and in vivo estrogen receptor activity

Chemico-Biological Interactions(2022)10.1016/j.cbi.2022.109995

N/A

0DataRank · unranked

7 citations

Jie Liu, Nicole Kleinstreuer, Maureen R. Gwinn, Natalia Ryan, J. Christopher Corton

PreSS/MD: Predictor of Skin Sensitization Caused by Chemicals Leaching from Medical Devices

ChemRxiv(2022)10.26434/chemrxiv-2022-z53kg

N/A

0DataRank · unranked

0 citations

Vinícius M. Alves, Rodolpho C. Braga, Daniel Korn, Nicole Kleinstreuer, Kevin Causey +4 more

New approach methodologies in human regulatory toxicology – Not if, but how and when!

Environment International(2023)10.1016/j.envint.2023.108082

N/A

0DataRank · unranked

339 citations

Andrea Miccoli, Martin von Bergen�, Elisabet Berggren, Albert Braeuning, Wibke Busch +24 more

International regulatory uses of acute systemic toxicity data and integration of new approach methodologies

Critical Reviews in Toxicology(2023)10.1080/10408444.2023.2240852

N/A

0DataRank · unranked

22 citations

Esther M. Haugabrooks, David Allen, Luciene B.L. Balottin, Yoko Hirabayashi, Nicole Kleinstreuer +11 more

Parallel evaluation of alternative skin barrier models and excised human skin for dermal absorption studies in vitro

Toxicology in Vitro(2023)10.1016/j.tiv.2023.105630

N/A

0DataRank · unranked

19 citations

Kelly J. Davis, Robert P. Felton, Nathania Nischal, Linda S. VonTungeln, Frederick A. Beland +12 more

Evaluation of the fish acute toxicity test for pesticide registration

Regulatory Toxicology and Pharmacology(2023)10.1016/j.yrtph.2023.105340

N/A

0DataRank · unranked

13 citations

David Allen, Amy Blankinship, Neepa Choksi, Amber B. Daniel, William P. Eckel +8 more

Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development

The Journal of Infectious Diseases(2023)10.1093/infdis/jiad334

N/A

0DataRank · unranked

7 citations

Stephanie L. Ford‐Scheimer, Rodolfo Alarcón, Anthony Atala, Jeffrey T. Borenstein, Kyle R. Brimacombe +23 more

DASS App: Integrating data from non-animal test methods to predict skin sensitization hazard and potency

(2023)10.33774/coe-2023-z56nq

N/A

0DataRank · unranked

1 citations

Judy Strickland, Emily N. Reinke, Alexandre Borrel, Jim Truax, Heather Maldonado +3 more

Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)*

Archives of Toxicology(2024)10.1007/s00204-023-03666-2

N/A

0DataRank · unranked

106 citations

Thomas Härtung, Nicole Kleinstreuer

The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization

Current Research in Toxicology(2024)10.1016/j.crtox.2024.100205

N/A

0DataRank · unranked

24 citations

Joe Reynolds, N. Gilmour, G. Reynolds, Judy Strickland, Dori R. Germolec +4 more

Democratizing cheminformatics: interpretable chemical grouping using an automated KNIME workflow

Journal of Cheminformatics(2024)10.1186/s13321-024-00894-1

N/A

0DataRank · unranked

23 citations

Dhruv Ranganath, Mike Conway, Charles Schmitt, Nicole Kleinstreuer, Kamel Mansouri +1 more

Unlocking the Potential of Clustering and Classification Approaches: Navigating Supervised and Unsupervised Chemical Similarity

Environmental Health Perspectives(2024)10.1289/ehp14001

N/A

0DataRank · unranked

17 citations

Kyla W. Taylor, Scott S. Auerbach, Stephen Ferguson, Rachel P. Frawley, Jui-Hua Hsieh +10 more

Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency

Archives of Toxicology(2024)10.1007/s00204-023-03656-4

N/A

0DataRank · unranked

14 citations

Jaleh Abedini, David Allen, Dori R. Germolec, John Gordon, Hon-Sum Ko +9 more

Examining animal testing for risk assessment: A WC-12 workshop report

Regulatory Toxicology and Pharmacology(2024)10.1016/j.yrtph.2024.105564

N/A

0DataRank · unranked

11 citations

Agnes L. Karmaus, Nicole Kleinstreuer, Troy Seidle, Harald Schlatter, Michael G. Wade +2 more

Evaluation of in silico model predictions for mammalian acute oral toxicity and regulatory application in pesticide hazard and risk assessment

Regulatory Toxicology and Pharmacology(2024)10.1016/j.yrtph.2024.105614

N/A

0DataRank · unranked

10 citations

Kamel Mansouri, William P. Eckel, Michael B. Lowit, David Allen, Amy Blankinship +5 more

60 Years of the 3Rs symposium: Lessons learned and the road ahead

ALTEX(2024)10.14573/altex.2403061

N/A

0DataRank · unranked

10 citations

Rolf Baß, Rodger Curren, Julia H. Fentem, Alan M. Goldberg, Thomas Härtung +10 more

A novel approach to triazole fungicides risk characterization: Bridging human biomonitoring and computational toxicology

The Science of The Total Environment(2024)10.1016/j.scitotenv.2024.176003

N/A

0DataRank · unranked

8 citations

Nicole Kleinstreuer, Xiaoqing Chang, Luiz Francisco Machado da Costa, Alessandra C.P. Silvério, Isarita Martins +1 more

A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents

Toxics(2024)10.3390/toxics12110803

N/A

0DataRank · unranked

8 citations

José Teófilo Moreira‐Filho, Holli‐Joi Martin, James Wellnitz, Miguel Canamary Otoch, Marielle Rath +4 more

Development and validation of CYP26A1 inhibition assay for high‐throughput screening

Biotechnology Journal(2024)10.1002/biot.202300659

N/A

0DataRank · unranked

7 citations

Dongping Ma, Jocylin D. Pierro, Nancy Baker, Nicole Kleinstreuer, James J. Cali +3 more

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

Frontiers in Toxicology(2024)10.3389/ftox.2024.1321857

N/A

0DataRank · unranked

6 citations

Tuan Xu, Judy Strickland, Li Zhang, Yuhong Fang, Dingyin Tao +5 more

Computational application of internationally harmonized defined approaches to skin sensitization: DASS App

BMC Bioinformatics(2024)10.1186/s12859-023-05617-1

N/A

0DataRank · unranked

7 citations

Judy Strickland, Emily N. Reinke, Alexandre Borrel, Jim Truax, Heather Maldonado +3 more

Standardizing Extracted Data Using Automated Application of Controlled Vocabularies

Environmental Health Perspectives(2024)10.1289/ehp13215

N/A

0DataRank · unranked

3 citations

Jessica Wignall, S.M. Kovach, Neepa Choksi, Dave Allen, Joanne Trgovcich +11 more

STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity

UNC Libraries(2024)10.17615/brxt-n696

N/A

0DataRank · unranked

1 citations

Erik Overdahl, Eugene Muratov, Vinícius M. Alves, Kirsten E. Overdahl, David Allen +9 more

A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents

UNC Libraries(2024)10.17615/8pgs-2737

N/A

0DataRank · unranked

0 citations

Eugene Muratov, Holli‐Joi Martin, Ricardo Scheufen Tieghi, Miguel Canamary Otoch, Marielle Rath +4 more

Complement-ARIE: Catalyzing the development and adoption of new approach methodologies

NAM journal.(2025)10.1016/j.namjnl.2025.100026

N/A

0DataRank · unranked

9 citations

Andrew Wright, Nicole Kleinstreuer, Victoria Ledbetter, Katelynn A. Milora, Christine Happel +9 more

The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them

Cancer Epidemiology Biomarkers & Prevention(2020)10.1158/1055-9965.epi-19-1346

N/A

0DataRank · unranked

114 citations

Kathryn Z. Guyton, Nicole Kleinstreuer, Alexandre Borrel, Andrés Cárdenas, Weihsueh A. Chiu +18 more

Ways to broaden the awareness, consideration and adoption of new approach methodologies (NAMs)

ALTEX(2025)10.14573/altex.2505281

N/A

0DataRank · unranked

2 citations

David Allen, Jessie Carder, Elizabeth Farley-Dawson, Emily N. Reinke, Shannon T. Marko +3 more

Human organoids for Risk Group 4 virus research: a new frontier in investigating Nipah virus infection of the central nervous system

Journal of Virology(2025)10.1128/jvi.01070-25

N/A

0DataRank · unranked

2 citations

Shuǐqìng Yú, Amanda M.W. Hischak, Julie P. Tran, Jeremy J. Bearss, John G. Bernbaum +12 more

External Validation of STopTox – Novel Alternative Method (NAM) for Acute Systemic and Topical Toxicity

Environmental Health Perspectives(2025)10.1289/ehp16647

N/A

0DataRank · unranked

3 citations

Cleber C. Melo‐Filho, Holli‐Joi Martin, José Teófilo Moreira‐Filho, Tripp LaPratt, Dave Allen +5 more

High-throughput cytokine detection platform for evaluation of chemical induced microglial activation

SLAS TECHNOLOGY(2025)10.1016/j.slast.2025.100347

N/A

0DataRank · unranked

3 citations

Kelly E. Carstens, Ibukunoluwa Ipaye, Xing Chen, Helena T. Högberg, Nicole Kleinstreuer +3 more

Comparison of physiologically based pharmacokinetic modeling platforms for developmental neurotoxicity in vitro to in vivo extrapolation

Toxicological Sciences(2025)10.1093/toxsci/kfaf147

N/A

0DataRank · unranked

1 citations

Xiaoqing Chang, Michael S. Lawless, Susana Proença, Stephan Schaller, Nicole Kleinstreuer +2 more

The OASIS Consortium: integrating multi-omics technologies to transform chemical safety assessment

Toxicological Sciences(2025)10.1093/toxsci/kfaf128

N/A

0DataRank · unranked

7 citations

Andreas Bender, Jaime H. Cheah, Chrissy Crute, Deidre A. Dalmas, Jessica Ewald +11 more

An integrated chemical environment with tools for chemical safety testing

Toxicology in Vitro(2020)10.1016/j.tiv.2020.104916

N/A

0DataRank · unranked

71 citations

Jaleh Abedini, Patricia Ceger, Xiaoqing Chang, Bethany Cook, Agnes L. Karmaus +12 more

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential

Frontiers in Bioengineering and Biotechnology(2020)10.3389/fbioe.2020.00109

N/A

0DataRank · unranked

48 citations

Xue Liu, Masato Ooka, Li Zhang, Min Jae Song, Ruili Huang +5 more

STopTox: An In-Silico Alternative to Animal Testing for Acute Systemic and TOPical TOXicity

ChemRxiv(2020)10.26434/chemrxiv.13283930

N/A

0DataRank · unranked

6 citations

Vinícius M. Alves, Rodolpho C. Braga, Daniel Korn, Kirsten E. Overdahl, Arthur C. Silva +9 more

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds

UNC Libraries(2020)10.17615/n9k1-1442

N/A

0DataRank · unranked

0 citations

Nicole Kleinstreuer, Alexander Tropsha, Vinícius M. Alves, Denis Fourches, Eugene Muratov +2 more

QSAR models of human data can enrich or replace LLNA testing for human skin sensitization

UNC Libraries(2020)10.17615/3vcx-6145

N/A

0DataRank · unranked

0 citations

Nicole Kleinstreuer, Eugene Muratov, Denis Fourches, Alexander Tropsha, Judy Strickland +5 more

Nicole Kleinstreuer

Indexed papers

Top data-sharing exemplar

Papers