Kyle E. Orwig

Also affiliated with Magee-Womens Research Institute, Magee-Womens Hospital

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 29 papers. Top paper: “Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis”.

Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis

Developmental Cell(2020)10.1016/j.devcel.2020.05.010

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292 citations

Xianing Zheng, Sarah K. Munyoki, Qianyi Ma, Gabriel Manske, Christopher D. Green +5 more

Restoration of functional sperm production in irradiated pubertal rhesus monkeys by spermatogonial stem cell transplantation

Andrology(2020)10.1111/andr.12807

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31 citations

Jennifer Mitchell, Jennifer M. Meyer, Zhuang Wu, Truong Lam, T. Phan +9 more

Spermatogonial Stem Cell Culture in Oncofertility

Urologic Clinics of North America(2020)10.1016/j.ucl.2020.01.001

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30 citations

Kyle E. Orwig, Sherin David

Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.17.994509

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23 citations

Xianing Zheng, Sarah K. Munyoki, Qianyi Ma, Gabriel Manske, Christopher D. Green +5 more

TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice

Nature Communications(2021)10.1038/s41467-021-24130-8

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58 citations

Adrienne Niederriter Shami, Lindsay Moritz, Hailey Larose, Gabriel Manske, Qianyi Ma +12 more

Postpubertal spermatogonial stem cell transplantation restores functional sperm production in rhesus monkeys irradiated before and after puberty

Andrology(2021)10.1111/andr.13033

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29 citations

Jennifer Mitchell, Truong Lam, T. Phan, Jie Zhang, Ramesh Tailor +7 more

Unique metabolic phenotype and its transition during maturation of juvenile male germ cells

The FASEB Journal(2021)10.1096/fj.202002799r

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28 citations

Douglas Kondro, Diana Powell, Hanna Pulaski, Mark Ungrin, Jan‐Bernd Stukenborg +5 more

Blastocyst development after fertilization with in vitro spermatids derived from nonhuman primate embryonic stem cells

F&S Science(2021)10.1016/j.xfss.2021.09.001

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18 citations

In Ki Cho, Kanchana Punyawai, Brittany Gill, Jacqueline N. Langmo, Shivangi Nath +14 more

Recent advances: fertility preservation and fertility restoration options for males and females

Faculty Reviews(2021)10.12703/r/10-55

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15 citations

Kyle E. Orwig, Chatchanan Doungkamchan

Single residue substitution in protamine 1 disrupts sperm genome packaging and embryonic development in mice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.16.460631

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14 citations

Samantha B. Schon, Mashiat Rabbani, Sheng Yi, Devon F. Pendlebury, Ritvija Agrawal +13 more

Metabolic transitions define spermatogonial stem cell maturation

Human Reproduction(2022)10.1093/humrep/deac157

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34 citations

Rkia Dardari, Lin Su, Nathália de Lima e Martins Lara, Sarthak Sinha, Arzina Jaffer +7 more

A synopsis of global frontiers in fertility preservation

Journal of Assisted Reproduction and Genetics(2022)10.1007/s10815-022-02570-5

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22 citations

Monica M. Laronda, Madison Q. Gowett, K. Trotter, Hannah Anvari, F. Fei +42 more

Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

Cell Reports Medicine(2022)10.1016/j.xcrm.2021.100501

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11 citations

Wenjuan Zhu, Xinxiu Xu, Cullen B. Young, Tuantuan Tan, Amanda M. Smith +32 more

Dissecting the spermatogonial stem cell niche using spatial transcriptomics

Cell Reports(2023)10.1016/j.celrep.2023.112737

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42 citations

Xin Zhang, Qiqi Cao, Andre L. Caldeira‐Brant, Xiangfan Zhang, Youngmin Song +7 more

Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1

Nature Structural & Molecular Biology(2023)10.1038/s41594-023-01033-4

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28 citations

Samantha B. Schon, Mashiat Rabbani, Yi Sheng, Ritvija Agrawal, Juniper Glass-Klaiber +16 more

Multiomics approach to profiling Sertoli cell maturation during development of the spermatogonial stem cell niche

Molecular Human Reproduction(2023)10.1093/molehr/gaad004

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19 citations

Rkia Dardari, Nathália de Lima e Martins Lara, ter Keurs He, Heather Steele, Antoine Dufour +3 more

Human immature testicular tissue organ culture: a step towards fertility preservation and restoration

Frontiers in Endocrinology(2023)10.3389/fendo.2023.1242263

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19 citations

Andre L. Caldeira‐Brant, Tianjiao Chu, Shtaywy Abdalla, Kyle E. Orwig, Nagham Younis

Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

Cell Reports(2023)10.1016/j.celrep.2023.112749

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18 citations

Yan Liu, Froylan Sosa, Sumedha Gunewardena, Peter A. Crawford, Amanda C. Zielen +3 more

In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219925120

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16 citations

Priti Singh, Kerry J. Schimenti, Tina N. Tran, Robert Fragoza, Jimmaline J. Hardy +8 more

A bioengineered in situ ovary (ISO) supports follicle engraftment and live-births post-chemotherapy

Journal of Tissue Engineering(2023)10.1177/20417314231197282

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16 citations

Meena Sukhwani, Aimon Iftikhar, Alexis L. Nolfi, Ziyu Xian, Srujan Dadi +6 more

Genomic study of TEX15 variants: prevalence and allelic heterogeneity in men with spermatogenic failure

Frontiers in Genetics(2023)10.3389/fgene.2023.1134849

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9 citations

Jimmaline J. Hardy, Christopher Pombar, Andrea J. Berman, Agnieszka Malcher, Tara N. Gingrich +12 more

Perspectives: Methods for Evaluating Primate Spermatogonial Stem Cells

Methods in molecular biology(2023)10.1007/978-1-0716-3139-3_18

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2 citations

Kyle E. Orwig, Sarah K. Munyoki

A 20-year overview of fertility preservation in boys: new insights gained through a comprehensive international survey

Human Reproduction Open(2024)10.1093/hropen/hoae010

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56 citations

Nina Neuhaus, Claus Yding Andersen, Virginie Barraud‐Lange, Aude Braye, Cristina Eguizábal +23 more

A Report on Testicular Tissue Cryopreservation for Fertility Preservation in Children: Confirmation of Germ Cell Preservation and Few Surgical Complications

Journal of Pediatric Surgery(2025)10.1016/j.jpedsurg.2025.162390

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6 citations

Kathryn L McElhinney, Barbara Lockart, Lori Schmitt, Amanda C. Zielen, Kyle E. Orwig +6 more

Is the time right for transplanting immature testicular tissue or cells to restore male fertility? Expert perspectives on clinical implementation of autotransplantation of cryopreserved testicular tissue or cells for fertility restoration

Best Practice & Research Clinical Obstetrics & Gynaecology(2025)10.1016/j.bpobgyn.2025.102638

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6 citations

Ellen Goossens, Rod T. Mitchell, Kyle E. Orwig, C.L. Mulder, Ans M. M. van Pelt +17 more

Non-human primates as a translational model for the study of male reproductive health

Nature Reviews Urology(2025)10.1038/s41585-025-01062-2

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2 citations

Jasper C. Bash, Lyndsey E. Shorey‐Kendrick, R D'mello, Travis Rice‐Stitt, Olivia L. Hagen +7 more

SATINN v2: automated image analysis for mouse testis histology with multi-laboratory data integration

Biology of Reproduction(2025)10.1093/biolre/ioaf033

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1 citations

Fritzie T. Celino‐Brady, Jessica E. M. Dunleavy, Katinka A. Vigh‐Conrad, Georgia Rae Atkins, Rachel L Hvasta +7 more

A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitness

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.18.688960

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1 citations

Christopher J. Woodilla, Ritvija Agrawal, Mashiat Rabbani, Samantha B. Schon, Wen Xie +10 more

Normal embryo development needs MEIG1 ‐mediated sperm formation

The FASEB Journal(2025)10.1096/fj.202500109r

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0 citations

Yi Tian Yap, Wei Li, Opeyemi Dhikhirullahi, Changning Niu, Mashiat Rabbani +5 more