Guangrong Zheng

Also affiliated with University of Florida Health, University of Florida, Yunnan Center for Disease Control And Prevention, Medicina, Yan'an Hospital Affiliated To Kunming Medical University, Florida College

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 50 papers. Top paper: “BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers”.

BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers

Journal of Hematology & Oncology(2022)10.1186/s13045-022-01241-3

N/A

0.621DataRank · unranked

62 citations

J Wiegand, Peiyi Zhang, Wanyi Hu, Dinesh Thummuri, Vivekananda Budamagunta +9 more

First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies

Journal of Hematology & Oncology(2025)10.1186/s13045-025-01753-8

N/A

0.436DataRank · unranked

14 citations

Minal Barve, Devalingam Mahalingam, Jay Parekh, Michael R. Kurman, James Strauss +10 more

ROS-mediated SRMS activation confers platinum resistance in ovarian cancer

Oncogene(2023)10.1038/s41388-023-02679-6

N/A

0.406DataRank · unranked

14 citations

Lina Song, Yizhu Lin, Paweł Nowialis, Qiongmei Gao, Tao Li +8 more

Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia

Genes & Diseases(2024)10.1016/j.gendis.2024.101452

N/A

0.396DataRank · unranked

13 citations

Zhixing Wu, Yafang Li, Alexis R. Smith, Yutao Zhang, Jue Wang +7 more

A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR

Neoplasia(2024)10.1016/j.neo.2024.101070

N/A

0.330DataRank · unranked

8 citations

Gerik W. Tushoski-Alemán, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Zhiguang Huo +6 more

Targeting Lineage-Specific Functions of NR4A1 for Cancer Immunotherapy

International Journal of Molecular Sciences(2025)10.3390/ijms26115266

N/A

0.330DataRank · unranked

8 citations

Akhila Nataraj, Yufeng Xiao, Bristy Rani Podder, Zeng Jin, Tanzia Islam Tithi +8 more

PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.27.582353

N/A

0.312DataRank · unranked

7 citations

Lin Cao, J Wiegand, Peiyi Zhang, Maria Zajac‐Kaye, Frederic J. Kaye +3 more

Quiescent OXPHOS-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend on BCL-XL for Survival

Cells(2025)10.3390/cells14191557

N/A

0.104DataRank · unranked

1 citations

Marie Winter, Leandro Encarnação Garcia, Olusiji Akinrinmade, Francisco Madeira Marques, Emmanouil Zacharioudakis +10 more

Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115498

N/A

0DataRank · unranked

8 citations

Zhengya Gao, Qiang Fu, Lin Song, Peiyi Zhang, Xuan Zhang +5 more

PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

Exploration of Targeted Anti-tumor Therapy(2020)10.37349/etat.2020.00017

N/A

0DataRank · unranked

23 citations

Xuan Zhang, Xingui Liu, Sajid Khan, Daohong Zhou, Guangrong Zheng +1 more

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

Nature Communications(2021)10.1038/s41467-021-27210-x

N/A

0DataRank · unranked

149 citations

Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang +19 more

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL–Specific Degrader DT2216

Molecular Cancer Therapeutics(2021)10.1158/1535-7163.mct-21-0474

N/A

0DataRank · unranked

74 citations

Sajid Khan, Patrick W. Underwood, Peiyi Zhang, J Wiegand, Xuan Zhang +13 more

Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells

Nature Communications(2021)10.1038/s41467-021-21573-x

N/A

0DataRank · unranked

55 citations

Umasankar De, Sajid Khan, Yuewan Luo, Myung‐Chul Kim, Haijun Yu +14 more

Concise Synthesis of (S)-δ-CEHC, a Metabolite of Vitamin E

ACS Omega(2021)10.1021/acsomega.0c05658

N/A

0DataRank · unranked

4 citations

Pratik Pal, Peiyi Zhang, Xuan Zhang, Guangrong Zheng, Matthew Burke

Overcoming Cancer Drug Resistance Utilizing PROTAC Technology

Frontiers in Cell and Developmental Biology(2022)10.3389/fcell.2022.872729

N/A

0DataRank · unranked

120 citations

Alexis R. Smith, Guangrong Zheng, Matthew R. Burke

PROTAC therapy as a new targeted therapy for lung cancer

Molecular Therapy(2022)10.1016/j.ymthe.2022.11.011

N/A

0DataRank · unranked

83 citations

Guangrong Zheng, Frederic J. Kaye, Lizi Wu, Jennifer W. Li

Targeting BCL-XL in fibrolamellar hepatocellular carcinoma

JCI Insight(2022)10.1172/jci.insight.161820

N/A

0DataRank · unranked

27 citations

Denise Ng, Gadi Lalazar, Carly Rosemore, Tova M. Finkelstein, Rachael D. Migler +13 more

Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis

Cancer Chemotherapy and Pharmacology(2022)10.1007/s00280-022-04490-8

N/A

0DataRank · unranked

19 citations

Aruna S. Jaiswal, Elizabeth A. Williamson, Jonathon Gelfond, Guangrong Zheng, Daohong Zhou +2 more

Piperlongumine (PL) conjugates induce targeted protein degradation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.21.474712

N/A

0DataRank · unranked

6 citations

Yufeng Xiao, Xingui Liu, Wanyi Hu, Amin Sobh, Yaxia Yuan +12 more

Co-targeting BCL-X L and MCL-1 with DT2216 and AZD8055 synergistically inhibits small-cell lung cancer growth without causing on-target toxicities in mice

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.12.507616

N/A

0DataRank · unranked

0 citations

Patrick Kellish, Nick Connis, Dinesh Thummuri, J Wiegand, Peiyi Zhang +14 more

Piperlongumine conjugates induce targeted protein degradation

Cell chemical biology(2023)10.1016/j.chembiol.2023.01.004

N/A

0DataRank · unranked

71 citations

Yufeng Xiao, Xingui Liu, Wanyi Hu, Amin Sobh, Yaxia Yuan +12 more

Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells

Haematologica(2023)10.3324/haematol.2022.281915

N/A

0DataRank · unranked

68 citations

Lina Han, Cassandra L. Ramage, Zhe Wang, Connie C. Weng, Lei Yang +15 more

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Cell Death Discovery(2023)10.1038/s41420-022-01296-8

N/A

0DataRank · unranked

43 citations

Patrick Kellish, Nick Connis, Dinesh Thummuri, J Wiegand, Peiyi Zhang +14 more

HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation

Cell chemical biology(2023)10.1016/j.chembiol.2023.07.010

N/A

0DataRank · unranked

43 citations

Seth Hale, Nikee Awasthee, Chengcheng Meng, Xuan Zhang, Yi Liu +8 more

Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy

Life Medicine(2023)10.1093/lifemedi/lnad019

N/A

0DataRank · unranked

11 citations

Rohan Master, Myung‐Chul Kim, Zeng Jin, Lei Wang, Chandra K. Maharjan +8 more

Design and optimization of piperlongumine analogs as potent senolytics

Bioorganic & Medicinal Chemistry Letters(2023)10.1016/j.bmcl.2023.129593

N/A

0DataRank · unranked

4 citations

Yonghan He, Xingui Liu, Xin Zhang, Peizhong Shi, Yingying Wang +3 more

Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.09.552650

N/A

0DataRank · unranked

0 citations

Yufeng Xiao, Yuewan Luo, Rohan Master, Jiao Mo, Myung‐Chul Kim +11 more

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Nature Communications(2024)10.1038/s41467-024-46922-4

N/A

0DataRank · unranked

49 citations

Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak +8 more

Targeted Protein Degradation: Current and Emerging Approaches for E3 Ligase Deconvolution

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c00723

N/A

0DataRank · unranked

33 citations

Yaxia Yuan, Yi Liu, Zongtao Lin, Guangrong Zheng, Daohong Zhou +2 more

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Nature Communications(2020)10.1038/s41467-020-15838-0

N/A

0DataRank · unranked

260 citations

Xuan Zhang, Jianhui Chang, Ha‐Neui Kim, Peiyi Zhang, Yingying Wang +17 more

PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy

The Journal of Experimental Medicine(2024)10.1084/jem.20231519

N/A

0DataRank · unranked

28 citations

Yufeng Xiao, Yuewan Luo, Rohan Master, Jiao Mo, Myung‐Chul Kim +17 more

Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c00761

N/A

0DataRank · unranked

18 citations

Nikee Awasthee, Yi Liu, Chengcheng Meng, Michael Y. He, Seth Hale +8 more

Targeted degradation of specific TEAD paralogs by small molecule degraders

Heliyon(2024)10.1016/j.heliyon.2024.e37829

N/A

0DataRank · unranked

11 citations

Artem Gridnev, Netanya Schlamowitz, Wanyi Hu, Kuntala Dey, Guangrong Zheng +2 more

Design, Synthesis, and Evaluation of BCL‐2 Targeting PROTACs

Chemistry - A European Journal(2024)10.1002/chem.202400430

N/A

0DataRank · unranked

8 citations

Yuen Lam Dora Ng, Martina Gobec, Robert D. Kuchta, Wanyi Hu, Špela Javornik +7 more

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.12.20.629607

N/A

0DataRank · unranked

0 citations

Scott Haston, Romain Guiho, Diana Carvahlo, Rebecca Carter, Jessica K.R. Boult +21 more

A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

Nature Aging(2025)10.1038/s43587-025-00811-7

N/A

0DataRank · unranked

48 citations

Natacha Jn-Simon, Yonghan He, Chunbao Sun, Peiyi Zhang, Wanyi Hu +11 more

Proteolysis Targeting Chimera Loaded Extracellular Vesicles for Developing Triple Negative Breast Cancer Treatment

Journal of Extracellular Vesicles(2025)10.1002/jev2.70211

N/A

0DataRank · unranked

7 citations

Umasankar De, Yufeng Xiao, Lei Wang, Chandra K. Maharjan, Xiaoshu Pan +7 more

Discovery of XZ338, a highly potent BCL-XL degrader

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117624

N/A

0DataRank · unranked

5 citations

Dinesh Thummuri, Wanyi Hu, Xingui Liu, Peiyi Zhang, Shuo Zhou +3 more

Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader

RSC Medicinal Chemistry(2025)10.1039/d5md00119f

N/A

0DataRank · unranked

3 citations

Dinesh Thummuri, Wanyi Hu, Sajid Khan, Yonghan He, Xuan Zhang +5 more

Quiescent OXPHOS-high triple-negative breast cancer cells that persist after chemotherapy depend on BCL-XL for survival

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.21.671546

N/A

0DataRank · unranked

2 citations

Marie Winter, Leandro Encarnacao. Garcia, Olusiji Akinrinmade, Francisco Madeira Marques, Emmanouil Zacharioudakis +10 more

Unveiling BCL-xL-specific PROTAC Efficiency and Dissociation Mechanisms Using Native Mass Spectrometry

ChemRxiv(2025)10.26434/chemrxiv-2025-zfjsj

N/A

0DataRank · unranked

1 citations

Kailyn L. Nonhof, Digant Nayak, Peiyi Zhang, Olivia E. Dioli, Guangrong Zheng +4 more

PROTAC-Mediated Targeting of IKKβ and NR4A1 for AML Therapy

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.24.678355

N/A

0DataRank · unranked

0 citations

Yi Liu, Yufeng Xiao, Bristy Rani Podder, Terri Montgomery, Lei Wang +11 more

PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer

Cells(2024)10.3390/cells13060528

N/A

0DataRank · unranked

29 citations

Lin Cao, J Wiegand, Peiyi Zhang, Maria Zajac‐Kaye, Frederic J. Kaye +3 more

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

Journal of Hematology & Oncology(2020)10.1186/s13045-020-00928-9

N/A

0DataRank · unranked

134 citations

Raphael Koch, Vivekananda Budamagunta, Peiyi Zhang, Xuan Zhang, Sajid Khan +11 more

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

Journal of Hematology & Oncology(2020)10.1186/s13045-020-00924-z

N/A

0DataRank · unranked

123 citations

Sajid Khan, Zhiguang Huo, Dongwen Lv, Xuan Zhang, Xingui Liu +6 more

Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs

Chemical Communications(2020)10.1039/d0cc03243c

N/A

0DataRank · unranked

120 citations

Wei Jia, Lisa Zhao, Xinyi Chen, Guangrong Zheng, Xuan Zhang +2 more

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112186

N/A

0DataRank · unranked

115 citations

Dinesh Thummuri, Xingui Liu, Wanyi Hu, Peiyi Zhang, Sajid Khan +4 more

Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112397

N/A

0DataRank · unranked

65 citations

Yonghan He, Peiyi Zhang, Vivekananda Budamagunta, Dongwen Lv, Dinesh Thummuri +6 more

Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6

Biochemical Journal(2020)10.1042/bcj20200411

N/A

0DataRank · unranked

23 citations

Shinji Maegawa, Yanwen Yang, Vidya Gopalakrishnan, Guangrong Zheng, Donghang Cheng +1 more

A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β

Molecules(2020)10.3390/molecules25245847

N/A

0DataRank · unranked

5 citations

Maroof K. Zafar, Xingui Liu, Robert L. Eoff, Guangrong Zheng, G. Satheesh