Seth A. Darst

Biochemistry, Genetics and Molecular BiologyEnvironmental ScienceMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 36 papers. Top paper: “Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex”.

Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00734-6

N/A

0.670DataRank · unranked

86 citations

Qi Wang, Brandon Malone, Eliza Llewellyn, Yakov Pechersky, Kashyap Maruthi +6 more

Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7

Molecular Cell(2021)10.1016/j.molcel.2021.05.017

N/A

0.568DataRank · unranked

43 citations

Seth A. Darst, Elizabeth A. Campbell, Mirjana Lilić

Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.13.584744

N/A

0.208DataRank · unranked

3 citations

Mueller AU, Brandon Malone, James Chen, William C. Budell, Venkata P. Dandey +9 more

Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase

Nature Communications(2025)10.1038/s41467-025-64941-7

N/A

0.165DataRank · unranked

2 citations

Madeleine Delbeau, Winston Bates Zoullas, Seth A. Darst, Elizabeth A. Campbell, Joshua J. Brewer

Time-resolved cryoEM using Spotiton

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.20.050518

N/A

0DataRank · unranked

6 citations

William C. Budell, Hui Wei, Daija Bobe, Kashyap Maruthi, Mykhailo Kopylov +14 more

Structural basis for transcription complex disruption by the Mfd translocase

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.12.248500

N/A

0DataRank · unranked

6 citations

Eliza Llewellyn, James Chen, Paul Dominic B. Olinares, Joshua J. Brewer, Brian T. Chait +3 more

Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2102516118

N/A

0DataRank · unranked

127 citations

James Chen, Qi Wang, Eliza Llewellyn, Young Joo Choi, Paul Dominic B. Olinares +9 more

Structural origins of Escherichia coli RNA polymerase open promoter complex stability

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2112877118

N/A

0DataRank · unranked

42 citations

James Chen, Courtney Chiu, Brandon Malone, J Sotiris, Mark Ebrahim +4 more

Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals

mSphere(2021)10.1128/msphere.00711-21

N/A

0DataRank · unranked

29 citations

Hans-Heinrich Hoffmann, Young Joo Choi, Gabriel I. Small, Alison W. Ashbrook, Bimal Koirala +5 more

Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.13.435256

N/A

0DataRank · unranked

27 citations

James Chen, Qi Wang, Eliza Llewellyn, Young Joo Choi, Paul Dominic B. Olinares +9 more

Ensemble cryo-electron microscopy reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.10.468168

N/A

0DataRank · unranked

11 citations

Qi Wang, Brandon Malone, Eliza Llewellyn, Yakov Pechersky, Kashyap Maruthi +6 more

Structural origins of Escherichia coli RNA polymerase open promoter complex stability

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.08.459427

N/A

0DataRank · unranked

0 citations

James Chen, Courtney Chiu, Brandon Malone, J Sotiris, Mark Ebrahim +4 more

Polarity of the CRISPR roadblock to transcription

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00864-x

N/A

0DataRank · unranked

31 citations

James T. Inman, Robert M. Fulbright, Tung T. Le, Joshua J. Brewer, Guillaume Lambert +3 more

An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.11.507475

N/A

0DataRank · unranked

2 citations

Tatiana V. Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu +3 more

Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.21.513233

N/A

0DataRank · unranked

1 citations

Expery O. Omollo, Ruby Froom, Steven Koh, Rachel A. Mooney, Mirjana Lilić +6 more

Structural basis for substrate selection by the SARS-CoV-2 replicase

Nature(2023)10.1038/s41586-022-05664-3

N/A

0DataRank · unranked

87 citations

Jason K. Perry, Paul Dominic B. Olinares, Hery W. Lee, James Chen, T.C. Appleby +14 more

Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis

Molecular Cell(2023)10.1016/j.molcel.2023.04.007

N/A

0DataRank · unranked

39 citations

Expery O. Omollo, Ruby Froom, Steven Koh, Rachel A. Mooney, Mirjana Lilić +6 more

An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2215945120

N/A

0DataRank · unranked

28 citations

Tatiana V. Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James H. Liu +3 more

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain

Molecular Cell(2023)10.1016/j.molcel.2023.10.001

N/A

0DataRank · unranked

22 citations

Olga Fedorova, Paul Dominic B. Olinares, Joshua Chandanani, Anoosha Banerjee, Young Joo Choi +5 more

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

mBio(2023)10.1128/mbio.01060-23

N/A

0DataRank · unranked

20 citations

Young Joo Choi, Anoosha Banerjee, Gabriel I. Small, Jordan Anderson-Daniels, Jennifer Gribble +8 more

Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by Achromobacter

Journal of Natural Products(2023)10.1021/acs.jnatprod.3c00536

N/A

0DataRank · unranked

13 citations

Yi Zhang, Larry So, Wai Ling Cheung‐Lee, Alexis Jaramillo Cartagena, Seth A. Darst +2 more

A general mechanism for transcription bubble nucleation in bacteria

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2220874120

N/A

0DataRank · unranked

10 citations

James Chen, Mengyu Wu, Courtney Chiu, B. Tracy Nixon, Elizabeth A. Campbell +2 more

Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by Achromobacter

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.21.545946

N/A

0DataRank · unranked

1 citations

Yi Zhang, Larry So, Wai Ling Cheung‐Lee, Alexis Jaramillo Cartagena, Seth A. Darst +2 more

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.25.558837

N/A

0DataRank · unranked

1 citations

Olga Fedorova, Paul Dominic B. Olinares, Joshua Chandanani, Anoosha Banerjee, Young Joo Choi +5 more

Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy

Nature Structural & Molecular Biology(2024)10.1038/s41594-024-01349-9

N/A

0DataRank · unranked

12 citations

Mueller AU, Brandon Malone, James Chen, William C. Budell, Venkata P. Dandey +9 more

The yin and yang of the universal transcription factor NusG

Current Opinion in Microbiology(2024)10.1016/j.mib.2024.102540

N/A

0DataRank · unranked

3 citations

Ruby Froom, Robert Landick, Seth A. Darst, Elizabeth A. Campbell, Madeleine Delbeau

Molecular switching of a DNA-sliding clamp to a repressor mediates long-range gene silencing

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.16.579611

N/A

0DataRank · unranked

6 citations

Francisco de Asís Balaguer, Joshua Chandanani, Christopher M. Thomas, Clara Aicart-Ramos, Sophia Burick +10 more

KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid

Nature Microbiology(2025)10.1038/s41564-024-01915-3

N/A

0DataRank · unranked

14 citations

Francisco de Asís Balaguer, Joshua Chandanani, Christopher M. Thomas, Clara Aicart-Ramos, Sophia Burick +10 more

The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved

Cell(2025)10.1016/j.cell.2025.05.044

N/A

0DataRank · unranked

4 citations

Seth A. Darst, Elizabeth A. Campbell, Gabriel I. Small

Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding

Nature Communications(2025)10.1038/s41467-025-61837-4

N/A

0DataRank · unranked

1 citations

N Molina, B. Tracy Nixon, Seth A. Darst, Mueller AU

Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.01.662654

N/A

0DataRank · unranked

2 citations

Lili M. Kim, Jürgen Jänes, Hannah N. Burkhart, Seth A. Darst, Pedro Beltrão +2 more

Time-resolved cryo-EM using Spotiton

Nature Methods(2020)10.1038/s41592-020-0925-6

N/A

0DataRank · unranked

153 citations

William C. Budell, Hui Wei, Daija Bobe, Kashyap Maruthi, Mykhailo Kopylov +14 more

Desiccation-induced DNA damage facilitates drug resistance in Mycobacterium tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.04.657859

N/A

0DataRank · unranked

1 citations

Brenda Lee, Han Liu, Airong Wu, Adrián Téllez, Hejian Zou +15 more

The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2013706117

N/A

0DataRank · unranked

43 citations

James Chen, Hande Boyaci, Nathaniel R. Braffman, Elizabeth A. Hubin, Jennifer Herrmann +6 more

Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM

Structure(2020)10.1016/j.str.2020.11.001

N/A

0DataRank · unranked

33 citations

Jin Young Kang, Eliza Llewellyn, Courtney Chiu, James Chen, Brandon Malone +5 more

Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.08.194084

N/A

0DataRank · unranked

47 citations

Brandon Malone, Eliza Llewellyn, Michael Grasso, Patrick M. M. Shelton, Paul Dominic B. Olinares +8 more