Sergio C. Chai

Also affiliated with High Throughput Biology (United States)

Pharmacology, Toxicology and PharmaceuticsMedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 14 papers. Top paper: “Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2”.

Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2

Nature Communications(2024)10.1038/s41467-024-52966-3

N/A

0.494DataRank · unranked

26 citations

Suresh Dharuman, Elizabeth C. Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King +17 more

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic Acids Research(2023)10.1093/nar/gkad1175

N/A

0.352DataRank · unranked

7 citations

Shyaron Poudel, Jing Wu, Darcie J. Miller, Wenwei Lin, Lei Yang +7 more

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Angewandte Chemie International Edition(2021)10.1002/anie.202108848

N/A

0DataRank · unranked

159 citations

Anand Mayasundari, Fatemeh Keramatnia, Barbara Jonchère, Seung Wook Yang, Jamie Jarusiewicz +22 more

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Angewandte Chemie(2021)10.1002/ange.202108848

N/A

0DataRank · unranked

15 citations

Anand Mayasundari, Fatemeh Keramatnia, Barbara Jonchère, Seung Wook Yang, Jamie Jarusiewicz +22 more

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Nucleic Acids Research(2022)10.1093/nar/gkac133

N/A

0DataRank · unranked

38 citations

Efren Garcia-Maldonado, Sergio C. Chai, Boer Xie, Shirish Chodankar, Andrew D. Huber +10 more

E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity

Molecular Cell(2023)10.1016/j.molcel.2023.01.019

N/A

0DataRank · unranked

38 citations

Moeko T. King, Kheewoong Baek, Clifford T. Gee, Ravi Kalathur, Jerry Li +10 more

From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115246

N/A

0DataRank · unranked

8 citations

Anand Mayasundari, Gordana Tasić, Fatemeh Keramatnia, Timothy R. Stachowski, Huarui Cui +15 more

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors

ACS Medicinal Chemistry Letters(2023)10.1021/acsmedchemlett.3c00343

N/A

0DataRank · unranked

5 citations

Molly Sneddon, Joseph E. McPherson, Sourav Das, Clifford T. Gee, Michael J. Grillo +7 more

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small Molecule Inhibitors

ChemRxiv(2023)10.26434/chemrxiv-2023-8t7wn

N/A

0DataRank · unranked

1 citations

Molly Sneddon, Joseph McPherson, Sourav Das, Clifford T. Gee, Michael A. Grillo +7 more

Determination of Regulation of Drug Metabolizing Enzymes and Transporters

(2023)10.1002/9781119660699.ch41

N/A

0DataRank · unranked

0 citations

Taosheng Chen, Wen Xie, Sergio C. Chai

Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

Nature Communications(2024)10.1038/s41467-024-48472-1

N/A

0DataRank · unranked

20 citations

Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu +5 more

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.9b02067

N/A

0DataRank · unranked

59 citations

Jude Chenge, Jingheng Wang, Hazel M. Girvan, Lei Yang, Sergio C. Chai +6 more

Decoding the selective chemical modulation of CYP3A4

Nature Communications(2025)10.1038/s41467-025-58749-8

N/A

0DataRank · unranked

6 citations

Stanley Nithianantham, Sergio C. Chai, Kwan‐Young Jung, Lei Yang, Han Wee Ong +5 more

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Cancer Research(2020)10.1158/0008-5472.can-19-3934

N/A

0DataRank · unranked

41 citations

Liying Chi, Mi‐Kyung Yun, Lyudmila Tsurkan, Nancy E. Martinez, Barbara Jonchère +25 more