William C. Skarnes

Also affiliated with The Jackson Laboratory for Genomic Medicine

EngineeringMedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

2.7Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A resource of targeted mutant mouse lines for 5,061 genes

Nature Genetics(2021)10.1038/s41588-021-00825-y

Top 8%

2.7DataRank

Top 8%115 citations

Atsushi Yoshiki, David J. Adams, Shinya Ayabe, Arthur L. Beaudet, Joanna Bottomley +95 more

Papers

Driven by 28 papers — median percentile 92. Top paper: “A resource of targeted mutant mouse lines for 5,061 genes”.

A resource of targeted mutant mouse lines for 5,061 genes

Nature Genetics(2021)10.1038/s41588-021-00825-y

Top 8%

2.7DataRank

Top 8%115 citations

Atsushi Yoshiki, David J. Adams, Shinya Ayabe, Arthur L. Beaudet, Joanna Bottomley +95 more

Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

Journal of Neuroscience(2021)10.1523/jneurosci.0564-21.2021

N/A

1.2DataRank · unranked

51 citations

Maria I. Olivero-Acosta, Jingliang Zhang, Muriel Eaton, Anke M. Tukker, Xiaoling Chen +16 more

Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

Neuron(2021)10.1016/j.neuron.2021.03.022

N/A

0DataRank · unranked

107 citations

William C. Skarnes, Andrew Singleton, Mark Cookson, Michael E. Ward, Daniel M. Ramos

A reference induced pluripotent stem cell line for large-scale collaborative studies

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.15.472643

N/A

0DataRank · unranked

14 citations

Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng +90 more

Controlling homology-directed repair outcomes in human stem cells with dCas9

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.16.472942

N/A

0DataRank · unranked

12 citations

Gang Ning, Sofia Giansiracusa, Alexander S. Cruz, Cornelis Blauwendraat, Brandon Saavedra +5 more

Sodium channel Nav1.2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived from human iPSCs

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.18.427192

N/A

0DataRank · unranked

3 citations

Maria I. Olivero-Acosta, Jingliang Zhang, Muriel Eaton, William C. Skarnes, Yang Yang +1 more

Severe deficiency of voltage-gated sodium channel Na V 1.2 elevates neuronal excitability in adult mice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.02.429384

N/A

0DataRank · unranked

2 citations

Xiaoling Chen, Muriel Eaton, Shirong Lai, Anthony Park, Talha S. Ahmad +15 more

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Cell stem cell(2022)10.1016/j.stem.2022.11.004

N/A

0DataRank · unranked

307 citations

Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng +90 more

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Nature(2023)10.1038/s41586-023-06370-4

N/A

0DataRank · unranked

27 citations

Immacolata Porreca, Gennaro Iaconis, Hoi Ping Mok, Subhankar Mukhopadhyay, Emre Karakoç +66 more

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.26.563426

N/A

0DataRank · unranked

5 citations

Maria I. Olivero-Acosta, Ian Chen, Jingliang Zhang, Kyle Wettschurack, Jiaxiang Wu +17 more

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.01.541136

N/A

0DataRank · unranked

4 citations

Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Jonathan Jung, Shankaracharya +15 more

Genetic determinants of micronucleus formation in vivo

Nature(2024)10.1038/s41586-023-07009-0

N/A

0DataRank · unranked

55 citations

B. Barlas, R. E. McIntyre, Israel Salguero, Louise van der Weyden, Alberto Barros +80 more

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Nature Communications(2024)10.1038/s41467-024-46695-w

N/A

0DataRank · unranked

23 citations

Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya +19 more

Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-AssociatedSCN2A-L1342P Mutation

Journal of Neuroscience(2024)10.1523/jneurosci.2027-23.2024

N/A

0DataRank · unranked

13 citations

Maria I. Olivero-Acosta, Morgan Robinson, Ian Chen, Jingliang Zhang, Kyle Wettschurack +22 more

Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modeling

Cell stem cell(2024)10.1016/j.stem.2024.02.006

N/A

0DataRank · unranked

12 citations

Justin A. McDonough, Michael E. Ward, Mark Cookson, William C. Skarnes, Florian T. Merkle +1 more

Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Scientific Reports(2024)10.1038/s41598-024-72418-8

N/A

0DataRank · unranked

8 citations

Kevin A. Peterson, Brandon Willis, Denise G. Lanza, Elif F. Acar, Edward J. Ryder +95 more

Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.29.577739

N/A

0DataRank · unranked

4 citations

Justin A. McDonough, Michael E. Ward, Mark Cookson, William C. Skarnes, Florian T. Merkle +1 more

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

Cell Reports(2025)10.1016/j.celrep.2025.115961

N/A

0DataRank · unranked

26 citations

Jordy Sepulveda, Kory R. Johnson, Adrian Lita, Jaanam Gopalakrishnan, Dominic J. Acri +13 more

Chromosome 4 Duplication Associated with Strabismus Leads to Gene Expression Changes in iPSC-Derived Cortical Neurons

Genes(2025)10.3390/genes16010080

N/A

0DataRank · unranked

6 citations

William C. Skarnes, Ashish Jain, Sampath Kumar Vemula, Liang Sun, Shira Rockowitz +2 more

HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs

Cell Reports(2025)10.1016/j.celrep.2025.115568

N/A

0DataRank · unranked

1 citations

Yuliana Tan, William F. Flynn, Lili Sun, Ponthip Pratumkaew, Juliana Alcoforado Diniz +5 more

Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder

Human Genetics and Genomics Advances(2025)10.1016/j.xhgg.2025.100525

N/A

0DataRank · unranked

1 citations

Giulia S. Porcari, Lívia Sertori Finoti, Leonardo Ramos-Rodriguez, Devin M Burris, Justin A. McDonough +15 more

Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.07.647695

N/A

0DataRank · unranked

7 citations

Alan Napole, Aninda Dibya Saha, Duo Sun, Angelina Singavarapu, Liz Calzada +22 more

Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation: Microglial diversity and response in assembloids

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.04.657874

N/A

0DataRank · unranked

4 citations

Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li +13 more

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.02.657036

N/A

0DataRank · unranked

3 citations

Jingliang Zhang, Jiaxiang Wu, Morgan Robinson, Harish Kothandaraman, Ye-Eun Yoo +18 more

A xeno-free protocol for rapid differentiation of human iPSC-derived microglia from the KOLF2.1J reference line

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.28.667242

N/A

0DataRank · unranked

1 citations

Katherine R. Lewkowicz, Patricia A. Clow, Michael E. Ward, Mark R. Cookson, William C. Skarnes +2 more

Generation and basic characterization of a gene‐trap knockout mouse model of Scn2a with a substantial reduction of voltage‐gated sodium channel Nav1.2 expression

Genes Brain & Behavior(2020)10.1111/gbb.12725

N/A

0DataRank · unranked

41 citations

Jingliang Zhang, Zhixiong Ma, Anthony C. Park, Emma E Lietzke, Chloé Maricela Romero +15 more

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.18.670956

N/A

0DataRank · unranked

0 citations

Morgan Robinson, Zhefu Que, Zaiyang Zhang, Hope Harlow, Vinayak Shankar +20 more

Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice

Cell Reports(2021)10.1016/j.celrep.2021.109495

N/A

0DataRank · unranked

127 citations

Xiaoling Chen, Muriel Eaton, Jiaxiang Wu, Zhixiong Ma, Shirong Lai +16 more

William C. Skarnes

Indexed papers

Top data-sharing exemplar

Papers