Derek L. Bolhuis

University of North Carolina at Chapel Hill

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 31 papers. Top paper: “In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators”.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

PLoS Biology(2020)10.1371/journal.pbio.3000975

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0DataRank · unranked

21 citations

Raquel C. Martinez‐Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury +13 more

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.09.033621

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0DataRank · unranked

1 citations

Raquel C. Martinez‐Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury +11 more

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

The EMBO Journal(2021)10.15252/embj.2021108823

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15 citations

Derek L. Bolhuis, Anneroos E Nederstigt, Joshua A. Boyer, Brenda Temple, Thomas Bonacci +9 more

Cryo-EM structure of the plant 26S proteasome

Plant Communications(2022)10.1016/j.xplc.2022.100310

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16 citations

Irina Grishkovskaya, Katarina Belačić, Derek L. Bolhuis, Sascha Josef Amann, Brent Foster +9 more

Cryo-EM structure of the chain-elongating E3 ligase UBR5

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.03.515015

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3 citations

Irina Grishkovskaya, Hanna L. Brunner, Derek L. Bolhuis, Katarina Belačić, Alexander Schleiffer +4 more

Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

The EMBO Journal(2023)10.15252/embj.2022113348

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0DataRank · unranked

47 citations

Irina Grishkovskaya, Hanna L. Brunner, Derek L. Bolhuis, Katarina Belačić, Alexander Schleiffer +4 more

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase

Journal of the American Chemical Society(2023)10.1021/jacs.2c11294

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0DataRank · unranked

31 citations

Jarrett M. Pelton, Elizaveta T. Wick, Derek L. Bolhuis, Albert S. Baldwin, Michael J. Emanuele +3 more

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

Cancers(2023)10.3390/cancers15020517

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26 citations

Derek L. Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang +4 more

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

Nature Structural & Molecular Biology(2023)10.1038/s41594-023-01105-5

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18 citations

Kaeli A. Welsh, Derek L. Bolhuis, Ethan Paulаkonis, Raquel C. Martinez‐Chacin, Bei Liu +16 more

The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment

Developmental Cell(2023)10.1016/j.devcel.2023.10.002

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11 citations

Brandon M. Gassaway, Jonathan Tawil, Olivia Urso, Donald Pizzo, Kaeli A. Welsh +7 more

A divergent tumor overexpressed gene domain and oligomerization contribute to SPIRAL2 function in stabilizing microtubule minus ends

The Plant Cell(2023)10.1093/plcell/koad294

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4 citations

Natasha Bilkey, Derek L. Bolhuis, Kevin C. Slep, Ram Dixit, Yuanwei Fan

Crystal structure of the Arabidopsis SPIRAL2 C-terminal domain reveals a p80-Katanin-like domain

PLoS ONE(2023)10.1371/journal.pone.0290024

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3 citations

Ram Dixit, Kevin C. Slep, Derek L. Bolhuis

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.11.561963

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1 citations

Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang, Christine A. Mills +8 more

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

UNC Libraries(2023)10.17615/1wht-0y96

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0DataRank · unranked

0 citations

Yu Le, Derek L. Bolhuis, Xiaodong Wang, Nicholas G. Brown, Michael J. Emanuele +4 more

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Biochemical Society Transactions(2024)10.1042/bst20230454

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0DataRank · unranked

12 citations

Michael J. Emanuele, Nicholas G. Brown, Derek L. Bolhuis

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

Cell Reports(2024)10.1016/j.celrep.2024.114510

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12 citations

Kimberly Lukasik, Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang +10 more

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Nature Communications(2024)10.1038/s41467-024-46644-7

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7 citations

Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie +18 more

Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1

UNC Libraries(2024)10.17615/k601-kt77

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1 citations

Kaeli A. Welsh, Raquel C. Martinez‐Chacin, Nicholas G. Brown, Tatyana Bodrug, Liying Cui +2 more

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.28.596309

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0DataRank · unranked

1 citations

Derek L. Bolhuis, Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

UNC Libraries(2024)10.17615/cr0z-4y62

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0DataRank · unranked

0 citations

Charles D. Schwieters, Rolf E. Swenson, V. Keith Hughitt, Raj Chari, Venkata R. Sabbasani +18 more

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

UNC Libraries(2024)10.17615/sqdv-t262

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0DataRank · unranked

0 citations

Michael J. Emanuele, Nicholas G. Brown, Derek L. Bolhuis

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

UNC Libraries(2024)10.17615/s94d-5j87

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0DataRank · unranked

0 citations

Brenda Temple, Joshua P. Steimel, Li H. Gu, Anneroos E Nederstigt, Nicholas G. Brown +9 more

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

UNC Libraries(2024)10.17615/xm7a-6j77

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0DataRank · unranked

0 citations

Thomas Bonacci, Liying Cui, Sascha Josef Amann, William Zhang, Kaeli A. Welsh +16 more

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

UNC Libraries(2024)10.17615/5fdn-2z74

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0DataRank · unranked

0 citations

Tatyana Bodrug, Morgan E. Gibbs, Jan‐Michael Peters, Michael J. Emanuele, Jeanette Gowen Cook +10 more

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.03.610997

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0DataRank · unranked

0 citations

Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook +3 more

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

UNC Libraries(2024)10.17615/jj32-v329

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0DataRank · unranked

0 citations

Derek L. Bolhuis, Xianxi Wang, Ryan D. Mouery, E Drew Toomer, Timothy B. Branigan +10 more

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase

UNC Libraries(2024)10.17615/zv55-rv74

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0DataRank · unranked

0 citations

Sabrina E. Iskandar, Jarrett M. Pelton, Nicholas G. Brown, Elizaveta T. Wick, Michael J. Emanuele +3 more

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

Nature(2025)10.1038/s41586-025-09328-w

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0DataRank · unranked

10 citations

Derek L. Bolhuis, Hualong Yan, Sudipto Das, Xia Xu, Christina C. Abbate +8 more

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

Nature Communications(2025)10.1038/s41467-025-59770-7

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0DataRank · unranked

5 citations

Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook +3 more

Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110288

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0DataRank · unranked

2 citations

Derek L. Bolhuis, Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci

Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response

Cell chemical biology(2025)10.1016/j.chembiol.2025.11.007

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0 citations

Li H. Gu, Anneroos E Nederstigt, Logan J. Cope, Derek L. Bolhuis, Kim Harvey +19 more