Nobuyo Higashi‐Kuwata

National Center for Global Health and Medicine

MedicineComputer Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 17 papers. Top paper: “Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV”.

Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV

Journal of Hepatology(2020)10.1016/j.jhep.2020.12.006

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28 citations

Sanae Hayashi, Hiroki Kumamoto, Hiromi Ogata-Aoki, Debananda Das, David Venzon +12 more

7-Deaza-7-fluoro modification confers on 4′-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety

Antiviral Research(2020)10.1016/j.antiviral.2020.104744

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7 citations

Nobuyo Higashi‐Kuwata, Debananda Das, Kota Tomaya, Kohei Yamada, Shuko Murakami +7 more

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Nature Communications(2021)10.1038/s41467-021-20900-6

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196 citations

Nobuyo Higashi‐Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut +18 more

Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters

Journal of Virology(2021)10.1128/jvi.01551-21

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26 citations

Masaki Imai, Kenji Maeda, Noriko Nakajima, Nobuyo Higashi‐Kuwata, Kiyoko Iwatsuki‐Horimoto +9 more

Restoration of Neutralization Activity Against Omicron BA.2 and BA.5 in Older Adults and Individuals With Risk Factors Following the Fourth Dose of Severe Acute Respiratory Syndrome Coronavirus 2 BNT162b2 Vaccine

The Journal of Infectious Diseases(2022)10.1093/infdis/jiac393

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8 citations

Sachiko Otsu, Yasuko Ichikawa, Nobuyo Higashi‐Kuwata, Shuzo Matsushita, Shinya Shimada +2 more

Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands

ChemMedChem(2022)10.1002/cmdc.202200058

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6 citations

Satish Kovela, Ashish Sharma, Dana Shahabi, Ajay K. Ghosh, Denver R. Hopkins +11 more

Effects of a novel hepatitis B anti-viral drug E-CFCP in renal organic acid transporters

Journal of Pharmacological Sciences(2022)10.1016/j.jphs.2022.09.002

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1 citations

Hirofumi Hashimoto, Meika Kaneko, Shota Saito, Sangjon Pae, Shinpei Saito +6 more

Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

Nature Communications(2023)10.1038/s41467-023-36729-0

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45 citations

Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai +30 more

SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads

Bioorganic & Medicinal Chemistry Letters(2023)10.1016/j.bmcl.2023.129489

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12 citations

Dana Shahabi, Mackenzie E.C. Imhoff, Satish Kovela, Ashish Sharma, Shin-ichiro Hattori +4 more

A novel anti-HBV agent, E-CFCP, restores Hepatitis B virus (HBV)-induced senescence-associated cellular marker perturbation in human hepatocytes

Virus Research(2023)10.1016/j.virusres.2023.199094

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8 citations

Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya +2 more

Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement

Chemical and Pharmaceutical Bulletin(2023)10.1248/cpb.c23-00562

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8 citations

Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi‐Kuwata, Chika Azuma, Kouki Shinohara +8 more

Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent

RSC Advances(2023)10.1039/d3ra01750h

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2 citations

Nobuyo Higashi‐Kuwata, Sanae Hayashi, Debananda Das, Haydar Bulut, Ryoh Tokuda +9 more

Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116132

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15 citations

Monika Yadav, Iddum Satyanarayana, Somayeh Ghazi, Emma K. Lendy, Uttara Jayashankar +8 more

An orally available P1′-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier

PNAS Nexus(2024)10.1093/pnasnexus/pgae578

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9 citations

Haydar Bulut, Hironori Hayashi, Kohei Tsuji, Hiromi Ogata-Aoki, Maki Kiso +23 more

Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01520

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4 citations

Jyoti Vishwakarma, Katharina Sylvester, Nobuyo Higashi‐Kuwata, Agnieszka Dąbrowska, Renee Delgado +16 more

Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity

Virus Research(2025)10.1016/j.virusres.2025.199615

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3 citations

Mariko Kato, Shin-ichiro Hattori, Yuki Takamatsu, Hiroaki Mitsuya, Nobuyo Higashi‐Kuwata

SARS-CoV-2 Main Protease Inhibitors Containing 5-Substituted Benzothiazole-2-carbonyl Moieties at the P1′ Site and Their Derivatives

ACS Omega(2025)10.1021/acsomega.5c05168

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0 citations

Takuya Kobayakawa, Nobuyo Higashi‐Kuwata, Takahiro Ishii, Kouki Shinohara, Ryusei Yamamoto +5 more