William Lehman

MedicineBiochemistry, Genetics and Molecular BiologyPhysics and Astronomy

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 26 papers. Top paper: “Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments”.

Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments

Biophysical Journal(2020)10.1016/j.bpj.2020.05.017

N/A

0.568DataRank · unranked

43 citations

William Lehman, Michael J. Rynkiewicz, Elumalai Pavadai

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

The Journal of General Physiology(2021)10.1085/jgp.202012640

N/A

0.520DataRank · unranked

31 citations

Jin‐Kyu Park, Michael J. Rynkiewicz, Alice Ward Racca, Nikolaos Papoutsidakis, Jonas Schwan +6 more

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L

PNAS Nexus(2023)10.1093/pnasnexus/pgad011

N/A

0.496DataRank · unranked

14 citations

Michael J. Rynkiewicz, Jenette G. Creso, Lorenzo R. Sewanan, Lindsey Howland, Jeffrey R. Moore +3 more

Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle

The Journal of General Physiology(2023)10.1085/jgp.202313387

N/A

0.385DataRank · unranked

12 citations

Michael J. Rynkiewicz, William Lehman

Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms

Archives of Biochemistry and Biophysics(2025)10.1016/j.abb.2025.110380

N/A

0.104DataRank · unranked

1 citations

Michael J. Rynkiewicz, Wen Jian, An-Yue Tu, Michael Regnier, William Lehman +2 more

Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation

Archives of Biochemistry and Biophysics(2022)10.1016/j.abb.2022.109282

N/A

0DataRank · unranked

20 citations

Michael J. Rynkiewicz, Zeyu Yang, Ian R. Gould, Steven B. Marston, William Lehman +1 more

Modeling Human Cardiac Thin Filament Structures

Frontiers in Physiology(2022)10.3389/fphys.2022.932333

N/A

0DataRank · unranked

18 citations

Elumalai Pavadai, William Lehman, Michael J. Rynkiewicz

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

The Journal of General Physiology(2022)10.1085/jgp.202213274

N/A

0DataRank · unranked

17 citations

Michael J. Rynkiewicz, Elumalai Pavadai, Skylar M.L. Bodt, David V. Rasicci, Jeffrey R. Moore +4 more

Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

Cell Reports Medicine(2022)10.1016/j.xcrm.2021.100501

N/A

0DataRank · unranked

11 citations

Wenjuan Zhu, Xinxiu Xu, Cullen B. Young, Tuantuan Tan, Amanda M. Smith +32 more

Functional Remodeling of the Contractile Smooth Muscle Cell Cortex, a Provocative Concept, Supported by Direct Visualization of Cortical Remodeling

Biology(2022)10.3390/biology11050662

N/A

0DataRank · unranked

3 citations

William Lehman, Kathleen G. Morgan, Worawit Suphamungmee

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.23.509077

N/A

0DataRank · unranked

0 citations

Michael J. Rynkiewicz, D. Rassici, Skylar M.L. Bodt, Meaghan E. Barry, Esther Bullitt +4 more

Multi-scale modeling will unravel connections between sarcomeric mutations and cardiomyopathies

Journal of Molecular and Cellular Cardiology Plus(2022)10.1016/j.jmccpl.2022.100025

N/A

0DataRank · unranked

0 citations

Jeffrey R. Moore, Michael J. Rynkiewicz, William Lehman, Stuart G. Campbell

Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy–associated TPM1 variants

Journal of Clinical Investigation(2024)10.1172/jci179135

N/A

0DataRank · unranked

10 citations

Michael J. Rynkiewicz, Lynne Kim, Meaghan E. Barry, Ahmed Zied, Lorenzo R. Sewanan +5 more

Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization

Journal of Molecular and Cellular Cardiology(2024)10.1016/j.yjmcc.2024.01.004

N/A

0DataRank · unranked

8 citations

Michael J. Rynkiewicz, Elumalai Pavadai, Alex Viana, William Lehman, Jeffrey R. Moore +1 more

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

The Journal of General Physiology(2024)10.1085/jgp.202413538

N/A

0DataRank · unranked

8 citations

Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman +1 more

In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R

Frontiers in Physiology(2024)10.3389/fphys.2024.1452509

N/A

0DataRank · unranked

3 citations

Ilhan Gokhan, Michael J. Rynkiewicz, William Lehman, Jeffrey R. Moore, Stuart G. Campbell +1 more

The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction

iScience(2025)10.1016/j.isci.2025.111816

N/A

0DataRank · unranked

2 citations

Michael J. Rynkiewicz, Evan A. Despond, Meera Viswanathan, Aditi Madan, Kripa Chitre +6 more

Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state

Biochemical and Biophysical Research Communications(2025)10.1016/j.bbrc.2025.151595

N/A

0DataRank · unranked

0 citations

Michael J. Rynkiewicz, William Lehman, Balajee Ramachandran

Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants

Journal of Molecular and Cellular Cardiology(2025)10.1016/j.yjmcc.2025.04.009

N/A

0DataRank · unranked

0 citations

Stuart G. Campbell, Jeffrey R. Moore, William Lehman, Michael J. Rynkiewicz, Wen Jian

Evaluating pathogenicity of TPM1 variants of unknown significance using in-silico and in-vitro models

The Journal of Precision Medicine Health and Disease(2025)10.1016/j.premed.2025.100008

N/A

0DataRank · unranked

0 citations

Jenette G. Bellitto, Michael J. Rynkiewicz, Fanny Cheung, Darren Liu, Ilayda Firlar +7 more

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

Biophysical Journal(2020)10.1016/j.bpj.2020.07.006

N/A

0DataRank · unranked

56 citations

Elumalai Pavadai, Michael J. Rynkiewicz, Jonathan Walklate, Esther Bullitt, Jeffrey R. Moore +4 more

Pseudo-acetylation of ACTC1 K326 and K328 promotes dysinhibition of reconstituted human cardiac thin filaments

Journal of Molecular and Cellular Cardiology(2025)10.1016/j.yjmcc.2025.12.008

N/A

0DataRank · unranked

0 citations

Olga E. Karpicheva, Chloe J. King, Michael J. Rynkiewicz, Axel J. Fenwick, John F. Dawson +4 more

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy

Nature Communications(2020)10.1038/s41467-020-15922-5

N/A

0DataRank · unranked

29 citations

William M. Schmidt, Peter Franz, Michael J. Rynkiewicz, Christopher S. Newhard, Aditi Madan +5 more

C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state

Biochemical and Biophysical Research Communications(2021)10.1016/j.bbrc.2021.03.010

N/A

0DataRank · unranked

28 citations

Elumalai Pavadai, Michael J. Rynkiewicz, William Lehman

The Central Role of the F-Actin Surface in Myosin Force Generation

Biology(2021)10.3390/biology10121221

N/A

0DataRank · unranked

19 citations

William Lehman, Matthew H. Doran

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

The Journal of General Physiology(2022)10.1085/jgp.202213267

N/A

0DataRank · unranked

30 citations

Michael J. Rynkiewicz, David V. Rasicci, Skylar M.L. Bodt, Meaghan E. Barry, Esther Bullitt +4 more