Lori L. Isom

Biochemistry, Genetics and Molecular BiologyNeuroscienceMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 28 papers. Top paper: “Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons”.

Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons

Brain(2020)10.1093/brain/awaa247

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93 citations

Luis F. Lopez‐Santiago, Yukun Yuan, Trevor Glenn, Joshua L. Margolis, J. Clayton Walker +7 more

Dramatic Improvement in Seizures With Phenytoin Treatment in an Individual With Refractory Epilepsy and a SCN1B Variant

Pediatric Neurology(2020)10.1016/j.pediatrneurol.2020.03.012

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9 citations

Shane C. Quinonez, Bridget R. Becka, Lori L. Isom, Sucheta M. Joshi, Louis T. Dang

Variant-specific changes in persistent or resurgent Na + current in SCN8A -EIEE13 iPSC-derived neurons

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.16.909192

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0 citations

Luis F. Lopez‐Santiago, Yukun Yuan, Trevor Glenn, Joshua L. Margolis, J. Clayton Walker +4 more

Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform

Nature Communications(2021)10.1038/s41467-021-26496-1

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44 citations

Samuel J. DePalma, Yan-Ting Zhao, Adela Capilnasiu, Yu‐Wei Wu, Brynn Elder +14 more

Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling

JCI Insight(2021)10.1172/jci.insight.141776

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28 citations

Nnamdi Edokobi, Samantha L. Hodges, Alexa M. Pinsky, James Offord, Lin Piao +5 more

Gastrointestinal Symptoms and Channelopathy-Associated Epilepsy

The Journal of Pediatrics(2021)10.1016/j.jpeds.2021.06.034

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20 citations

Lori L. Isom, Anne T. Berg, Veronica C. Beck

Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits

JCI Insight(2021)10.1172/jci.insight.143092

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15 citations

Wei Wang, Paweorn Angsutararux, Rebecca L. Mellor, Lori L. Isom, Jeanne M. Nerbonne +2 more

Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.23.445330

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2 citations

Yan-Ting Zhao, Samuel J. DePalma, Adela Capilnasiu, Yu‐Wei Wu, Brynn Elder +12 more

Subcellular dynamics and functional activity of the cleaved Na + channel β1 subunit intracellular domain

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.29.474414

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1 citations

Samantha L. Hodges, Alina L. Capatina, Lori L. Isom, Christoph G. Baumann, William J. Brackenbury +1 more

Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress

Epilepsia(2022)10.1111/epi.17332

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144 citations

Ingo Helbig, Cameron S. Metcalf, Laura S. Lubbers, Lori L. Isom, Scott Demarest +8 more

Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation

JCI Insight(2022)10.1172/jci.insight.152050

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20 citations

Nnamdi Edokobi, Samantha L. Hodges, Shuyun Wang, Alexandra A. Bouza, Chandrika Canugovi +9 more

Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102174

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12 citations

Samantha L. Hodges, Alina L. Capatina, Lori L. Isom, Christoph G. Baumann, William J. Brackenbury +1 more

Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules

Pharmacological Reviews(2022)10.1124/pharmrev.121.000340

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8 citations

Alexandra A. Bouza, Lori L. Isom, Samantha L. Hodges

NADPH Oxidases and Oxidative Stress in the Pathogenesis of Atrial Fibrillation

Antioxidants(2023)10.3390/antiox12101833

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61 citations

Andrey Lozhkin, Aleksandr E. Vendrov, Marschall S. Runge, Lori L. Isom, Nageswara R. Madamanchi +1 more

Deriving early single-rosette brain organoids from human pluripotent stem cells

Stem Cell Reports(2023)10.1016/j.stemcr.2023.10.020

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51 citations

Wei Niu, Qianyi Ma, Taylor N. Takla, J. Clayton Walker, Joshua L. Margolis +12 more

Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model

Brain(2023)10.1093/brain/awad349

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50 citations

Luis F. Lopez‐Santiago, Nicholas Denomme, Chunling Chen, Heather A. O’Malley, Samantha L. Hodges +5 more

Hidden behavioral fingerprints in epilepsy

Neuron(2023)10.1016/j.neuron.2023.02.003

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47 citations

Ayman Zeine, Ivan Raikov, Jeffrey E. Markowitz, Winthrop F. Gillis, Sylwia Felong +4 more

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models

PLoS Biology(2023)10.1371/journal.pbio.3002078

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23 citations

René N. Caballero-Florán, Ty Hergenreder, Tao Yang, Jacob M. Hull, Geng Pan +9 more

Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy

Brain Communications(2023)10.1093/braincomms/fcad283

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14 citations

Julie Ziobro, Larissa Robinson‐Cooper, Samantha L. Hodges, Yan Chen, Nnamdi Edokobi +12 more

N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels

Molecular Pharmacology(2024)10.1124/molpharm.123.000837

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1 citations

Ciria C. Hernández, Hailey A. Bock, Rachel Friedman Ohana, Shreeya Bakshi, Alexander M. Sherwood +8 more

Memorial Tribute to William Albert Catterall (1946–2024)

Molecular Pharmacology(2024)10.1124/molpharm.124.000940

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0 citations

Lori L. Isom

NOX4-driven mitochondrial oxidative stress in aging promotes myocardial remodeling and increases susceptibility to ventricular tachyarrhythmia

Free Radical Biology and Medicine(2025)10.1016/j.freeradbiomed.2025.04.046

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13 citations

Shuyun Wang, Mark Stevenson, Andrey Lozhkin, Aleksandr E. Vendrov, Lori L. Isom +3 more

Neonatal but not juvenile gene therapy reduces seizures and prolongs lifespan in SCN1B–Dravet syndrome mice

Journal of Clinical Investigation(2025)10.1172/jci182584

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8 citations

Yukun Yuan, Heather A. O’Malley, Robert Duba-Kiss, Yan Chen, Karl Habig +5 more

Ontology accelerates few-shot learning capability of large language model: A study in extraction of drug efficacy in a rare pediatric epilepsy

International Journal of Medical Informatics(2025)10.1016/j.ijmedinf.2025.105942

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5 citations

Katrina Prantzalos, Veronica Hood, Mary Anne Meskis, Lori L. Isom, Karen S. Wilcox +14 more

Altered cardiac excitability and arrhythmia in models of SCN1B-linked developmental and epileptic encephalopathy

JCI Insight(2025)10.1172/jci.insight.190918

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3 citations

Shuyun Wang, Nnamdi Edokobi, Qinghua Liu, Xiaotan T. Qiao, Maya Shih +9 more

Mitochondrial NOX4 drives atrial fibrillation via redox-dependent structural remodeling and fibrosis

Free Radical Biology and Medicine(2025)10.1016/j.freeradbiomed.2025.10.303

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2 citations

Aleksandr E. Vendrov, Andrey Lozhkin, Eric N. Jiménez‐Vázquez, Shuyun Wang, Takayuki Hayami +5 more

Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy

Neurobiology of Disease(2025)10.1016/j.nbd.2025.106990

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1 citations

Samantha L. Hodges, Luis F. Lopez‐Santiago, Yukun Yuan, Julie Ziobro, Joe Minton +7 more

Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.01.662594

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4 citations

Miranda Walker, Jeyoon Bok, Emmanuel L. Crespo, Tyler Thenstedt, L. A. Goldstein +7 more