Douglas A. Mitchell

Also affiliated with University of Illinois Urbana-Champaign, Vanderbilt University

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 41 papers. Top paper: “Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family”.

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

BMC Genomics(2020)10.1186/s12864-020-06785-7

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0DataRank · unranked

157 citations

Sara M. Eslami, Kenton J. Hetrick, Sarah E. Ackenhusen, Douglas A. Mitchell, Wilfred A. van der Donk +1 more

RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery

mSystems(2020)10.1128/msystems.00267-20

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114 citations

Kyle E. Shelton, Gilles P. van Wezel, Marnix H. Medema, Douglas A. Mitchell, Alexander Kloosterman

Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

PLoS Biology(2020)10.1371/journal.pbio.3000507

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48 citations

Andi Liu, Neha Agrawal, Roy Rodriguez-Carerro, Shi‐Hui Dong, Douglas A. Mitchell +3 more

Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach

Journal of Natural Products(2020)10.1021/acs.jnatprod.9b00986

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39 citations

Simone M. Grendelmeier, Lonnie A. Harris, Douglas A. Mitchell, Karl Gademann, Simon Sieber

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.13.990614

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12 citations

Douglas A. Mitchell, Wilfred A. van der Donk, Mark C. Walker

Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate Tolerance

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.25.399105

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5 citations

Ashley M. Kretsch, Laura M. Daigh, Mark J. Burk, Douglas A. Mitchell, Yuanyuan Si

Structure Prediction and Synthesis of a New Class of Macrocyclic Peptide Natural Products

ChemRxiv(2020)10.26434/chemrxiv.11971950.v1

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2 citations

Annie R. Hooper, Adam J. DiCaprio, David Šarlah, Douglas A. Mitchell, Graham A. Hudson

Bioinformatic and Reactivity-Based Discovery of Linaridins

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.09.196543

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1 citations

Shravan R. Dommaraju, Xiaorui Guo, Douglas A. Mitchell, Matthew A. Georgiou

Reactivity-based screening for citrulline-containing natural products reveals a family of bacterial peptidyl arginine deiminases

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.16.207027

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1 citations

Patricia M. B. Saint‐Vincent, Xiaorui Guo, Graham A. Hudson, Douglas A. Mitchell, Lonnie A. Harris

Structure Prediction and Synthesis of a New Class of Macrocyclic Peptide Natural Products

ChemRxiv(2020)10.26434/chemrxiv.11971950

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0 citations

Annie R. Hooper, Adam J. DiCaprio, David Šarlah, Douglas A. Mitchell, Graham A. Hudson

Enzymatic thioamidation of peptide backbones

Methods in enzymology on CD-ROM/Methods in enzymology(2021)10.1016/bs.mie.2021.04.010

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2 citations

P.H. Krushnamurthy, K.S. Subramanya, Douglas A. Mitchell, Nilkamal Mahanta, Andi Liu

A scalable platform to discover antimicrobials of ribosomal origin

Nature Communications(2022)10.1038/s41467-022-33890-w

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105 citations

Chengyou Shi, Alexander J. Battiste, Sara M. Eslami, Sangeetha Ramesh, Max A. Simon +14 more

Oil Irradiation Experiments Document Changes in Oil Properties, Molecular Composition, and Dispersant Effectiveness Associated with Oil Photo-Oxidation

Environmental Science & Technology(2022)10.1021/acs.est.1c06149

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31 citations

Douglas A. Mitchell, Phoebe V. Keyes, Erin C. Beirne, Kelly M. McFarlin, Alina T. Roman‐Hubers +6 more

Bioinformatic prediction and experimental validation of RiPP recognition elements

Methods in enzymology on CD-ROM/Methods in enzymology(2022)10.1016/bs.mie.2022.08.050

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16 citations

Douglas A. Mitchell, Kyle E. Shelton

Radical SAM Enzymes and the Unexplored Chemistry of RiPP Biosynthesis

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.0i185

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0 citations

Timothy W. Precord, Graham A. Hudson, Nilkamal Mahanta, Brandon J. Burkhart, J.A. Gerlt +1 more

Genome mining unveils a class of ribosomal peptides with two amino termini

Nature Communications(2023)10.1038/s41467-023-37287-1

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42 citations

Shravan R. Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nešić +5 more

Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element

Biochemistry(2023)10.1021/acs.biochem.2c00700

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40 citations

Mayuresh G. Gadgil, Adam J. DiCaprio, Susanna E. Barrett, Bryce Kille, Yuanyuan Si +3 more

McrD binds asymmetrically to methyl-coenzyme M reductase improving active-site accessibility during assembly

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2302815120

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14 citations

Aaron M.N. Joiner, Sangeetha Ramesh, Douglas A. Mitchell, Dipti D. Nayak, Grayson L. Chadwick

Biosynthesis of macrocyclic peptides with C-terminal β-amino-α-keto acid groups by three different metalloenzymes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.30.564719

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2 citations

Lingyang Zhu, Danielle L. Gray, Toby J. Woods, Chandrashekhar Padhi, Kristen M. Flatt +3 more

Reverse-Engineered High-Yield Lasso Peptide Production in an Alternative Host

ChemRxiv(2023)10.26434/chemrxiv-2023-0f0km

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1 citations

Ashley M. Kretsch, Sylvia Kunakom, Adjo Kadjo, Douglas A. Mitchell, Alessandra S. Eustáquio +1 more

Genome mining unveils a class of ribosomal peptides with two amino termini

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.08.531785

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0DataRank · unranked

0 citations

Shravan R. Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nešić +5 more

Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.25.564083

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0 citations

Chunshuai Huang, Yuwei Pan, Haiyang Cui, Shravan R. Dommaraju, Douglas A. Mitchell +2 more

Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides

Nature Chemistry(2024)10.1038/s41557-024-01491-3

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22 citations

Chunshuai Huang, Yuwei Pan, Shravan R. Dommaraju, Haiyang Cui, Mao‐Lin Li +4 more

Genome Mining for New Enzyme Chemistry

ACS Catalysis(2024)10.1021/acscatal.3c06322

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48 citations

Douglas A. Mitchell, Wilfred A. van der Donk, Dinh Thanh Nguyen

Biosynthesis of Macrocyclic Peptides with C-Terminal β-Amino-α-keto Acid Groups by Three Different Metalloenzymes

ACS Central Science(2024)10.1021/acscentsci.4c00088

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0DataRank · unranked

44 citations

Lingyang Zhu, Danielle L. Gray, Toby J. Woods, Chandrashekhar Padhi, Kristen M. Flatt +3 more

Advances in lasso peptide discovery, biosynthesis, and function

Trends in Genetics(2024)10.1016/j.tig.2024.08.002

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44 citations

Douglas A. Mitchell, Susanna E. Barrett

Substrate interactions guide cyclase engineering and lasso peptide diversification

Nature Chemical Biology(2024)10.1038/s41589-024-01727-w

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29 citations

Yin Song, Peter Jordan, John K. Brunson, Jessica Gordon-Nunez, Gabriella Costa Machado da Cruz +9 more

Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications

Biochemistry(2024)10.1021/acs.biochem.4c00035

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27 citations

Hamada Saad, Kyle E. Shelton, Lingyang Zhu, Xiaorui Guo, Douglas A. Mitchell +1 more

Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C–C Bond Formation

Journal of the American Chemical Society(2024)10.1021/jacs.4c03994

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22 citations

Francesca Peccati, Claudio D. Navo, Gonzalo Jiménez‐Osés, Douglas A. Mitchell, Austin M. Woodard

High-Yield Lasso Peptide Production in a Burkholderia Bacterial Host by Plasmid Copy Number Engineering

ACS Synthetic Biology(2024)10.1021/acssynbio.3c00597

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25 citations

Ashley M. Kretsch, Sylvia Kunakom, Adjo Kadjo, Douglas A. Mitchell, Alessandra S. Eustáquio +1 more

Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling

ACS Chemical Biology(2024)10.1021/acschembio.4c00066

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9 citations

Riley S. Carter, Aman S. Imani, Shravan R. Dommaraju, Graham A. Hudson, Douglas A. Mitchell +2 more

Substrate prediction for RiPP biosynthetic enzymes via masked language modeling and transfer learning

Digital Discovery(2024)10.1039/d4dd00170b

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4 citations

Xuenan Mi, Douglas A. Mitchell, Diwakar Shukla, Joseph D. Clark

Enterolyin S, a Polythiazole‐containing Hemolytic Peptide from Enterococcus caccae

ChemBioChem(2024)10.1002/cbic.202400212

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2 citations

Varshal A. Patel, Douglas A. Mitchell, Huimin Zhao, Chengyou Shi

Computationally guided exploration of borosin biosynthetic strategies

AGU Fall Meeting Abstracts(2024)10.1101/2024.01.09.574750

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0 citations

Riley S. Carter, Aman S. Imani, Shravan R. Dommaraju, Graham A. Hudson, Douglas A. Mitchell +2 more

Cell-free synthetic biology for natural product biosynthesis and discovery

Chemical Society Reviews(2025)10.1039/d4cs01198h

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46 citations

Tien T. Sword, Kameshwari Chengan, Douglas A. Mitchell, Nigel J. Mouncey, Simon J. Moore +2 more

A Versatile Enzymatic Pathway for Modification of Peptide C-Termini

ACS Central Science(2025)10.1021/acscentsci.5c01243

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8 citations

Sanath K. Kandy, Hengqian Ren, Dominic Luciano, Shogo Fujiki, David Šarlah +4 more

LassoESM a tailored language model for enhanced lasso peptide property prediction

Nature Communications(2025)10.1038/s41467-025-63412-3

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4 citations

Susanna E. Barrett, Douglas A. Mitchell, Diwakar Shukla, Xuenan Mi

Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension

Journal of the American Chemical Society(2025)10.1021/jacs.5c12610

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4 citations

Josseline S. Ramos‐Figueroa, Alexander A. Vinogradov, Yuki Goto, Mayuresh G. Gadgil, Rebecca A. Splain +4 more

Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance

Cell Host & Microbe(2025)10.1016/j.chom.2025.11.007

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1 citations

Zhenrun J. Zhang, Shravan R. Dommaraju, Qiwen Dong, Rosemary L. Pope, Sophie S Son +9 more

A versatile enzymatic pathway for modification of peptide C-termini

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.11.664356

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0DataRank · unranked

0 citations

Sanath K. Kandy, Hengqian Ren, Dominic Luciano, Shogo Fujiki, David Šarlah +4 more

Aminoacyl-tRNA specificity of a ligase catalyzing non-ribosomal peptide extension

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.13.676032

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0DataRank · unranked

0 citations

Josseline S. Ramos‐Figueroa, Alexander A. Vinogradov, Yuki Goto, Mayuresh G. Gadgil, Rebecca A. Splain +4 more