Thomas Dick

Also affiliated with Hackensack Meridian Health, Center for Discovery

Agricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 51 papers. Top paper: “Pyrazinamide triggers degradation of its target aspartate decarboxylase”.

Pyrazinamide triggers degradation of its target aspartate decarboxylase

Nature Communications(2020)10.1038/s41467-020-15516-1

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122 citations

Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Shashi Bhushan +10 more

Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties

Frontiers in Microbiology(2020)10.3389/fmicb.2020.575586

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98 citations

Martin Gengenbacher, Véronique Dartois, Thomas Dick, Dereje A. Negatu

Extreme Drug Tolerance of Mycobacterium abscessus “Persisters”

Frontiers in Microbiology(2020)10.3389/fmicb.2020.00359

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80 citations

Nadine Álvarez, Mei‐Lin Go, Thomas Dick, Yee-Kuen Yam

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2020)10.1128/aac.02404-19

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63 citations

Uday S. Ganapathy, Matthew Zimmerman, Véronique Dartois, Martin Gengenbacher, Thomas Dick +1 more

Rifabutin: A Repurposing Candidate for Mycobacterium abscessus Lung Disease

Frontiers in Microbiology(2020)10.3389/fmicb.2020.00371

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12 citations

Thomas Dick

Rifabutin Suppresses Inducible Clarithromycin Resistance in Mycobacterium abscessus by Blocking Induction of whiB7 and erm41

Antibiotics(2020)10.3390/antibiotics9020072

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37 citations

Mei‐Lin Go, Thomas Dick, Dinah B. Aziz

Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy(2020)10.1128/aac.01100-20

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5 citations

Samuel Agyei Nyantakyi, Mei‐Lin Go, Thomas Dick, Ming Li

Critical discussion on drug efflux in Mycobacterium tuberculosis

FEMS Microbiology Reviews(2021)10.1093/femsre/fuab050

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76 citations

Jennifer C. Earp, Thomas Dick, Véronique Dartois, Markus A Seeger, Sille Remm

Epetraborole Is Active against Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2021)10.1128/aac.01156-21

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48 citations

Martin Gengenbacher, Thomas Dick, Uday S. Ganapathy

A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity

Antimicrobial Agents and Chemotherapy(2021)10.1128/aac.02420-20

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41 citations

Rubén González del Río, Mónica Cacho-Izquierdo, Fátima Ortega, Joël Lelièvre, David Barros-Aguirre +5 more

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2021)10.1128/aac.00978-21

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31 citations

Tian Lan, Philipp Krastel, Marissa Lindman, Matthew Zimmerman, Hsin‐Pin Ho +6 more

Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2021)10.1128/aac.00676-21

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29 citations

Andreas Beuchel, Abdeldjalil Madani, Nadine Álvarez, Chao Chen, Wassihun Wedajo Aragaw +7 more

A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2021)10.1128/aac.01514-21

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23 citations

Rubén González del Río, Mónica Cacho-Izquierdo, Fátima Ortega, Joël Lelièvre, David Barros-Aguirre +7 more

Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice

Antimicrobial Agents and Chemotherapy(2021)10.1128/aac.01400-21

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21 citations

Christine Roubert, Evelyne Fontaine, Sophie Lagrange, Matthew D. Zimmerman, Véronique Dartois +3 more

Reinvestigation of the structure-activity relationships of isoniazid

Tuberculosis(2021)10.1016/j.tube.2021.102100

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15 citations

Helena I. Boshoff, Yudi Rusman, Wassihun Wedajo Aragaw, Christine Salomon, Thomas Dick +2 more

Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F 420 H 2 -dependent reduction

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2025172118

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17 citations

Brendon M. Lee, Xuan Yang, Matthew Zimmerman, Martin Gengenbacher, Véronique Dartois +4 more

In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus

Microbiology Spectrum(2022)10.1128/spectrum.01321-21

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24 citations

Nicole Cotroneo, S. Stokes, Michael J. Pucci, Ian A. Critchley, Martin Gengenbacher +2 more

Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance

Angewandte Chemie International Edition(2022)10.1002/anie.202211498

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23 citations

Uday S. Ganapathy, Sachin Sharma, Yong‐Mo Ahn, Matthew Zimmerman, Vadim Molodtsov +8 more

A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study

Antimicrobial Agents and Chemotherapy(2022)10.1128/aac.02212-21

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21 citations

Jacqueline P. Ernest, Katherine LoMauro, Martin Gengenbacher, Abdeldjalil Madani, Wassihun Wedajo Aragaw +15 more

Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro

Antimicrobial Agents and Chemotherapy(2022)10.1128/aac.01237-22

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17 citations

Matthew Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick, Jickky Palmae Sarathy

Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.114916

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12 citations

Francesca Ferlenghi, Giannamaria Annunziato, Giulia Degiacomi, Bianca Papotti, Cinzia Marchi +11 more

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

Bioorganic & Medicinal Chemistry(2022)10.1016/j.bmc.2022.117046

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3 citations

Wassihun Wedajo Aragaw, Malcolm S. Cole, Gorakhnath R. Jachak, Priya Ragunathan, Sachin Sharma +5 more

Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2022)10.1128/aac.00669-22

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10 citations

Dereje A. Negatu, Abdellatif El Marrouni, Randy R. Miller, Christopher W. Boyce, Nicholas Murgolo +7 more

Structural and Mechanistic Insights into Mycobacterium abscessus Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor

ACS Infectious Diseases(2022)10.1021/acsinfecdis.2c00133

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7 citations

Chen Yen Leow, Amaravadhi Harikishore, Joon Shin, Malcolm S. Cole, Wassihun Wedajo Aragaw +6 more

Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.16.492225

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2 citations

Dereje A. Negatu, Abdellatif El Marrouni, Randy R. Miller, Christopher W. Boyce, Nicholas Murgolo +7 more

Mycobacterium tuberculosis DprE1 inhibitor OPC-167832 is active against Mycobacterium abscessus in vitro

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.14.508059

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1 citations

Matthew Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick, Jickky Palmae Sarathy

Strongly bactericidal all-oral β-lactam combinations for the treatment of Mycobacterium abscessus lung disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.07.495238

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0 citations

Matthew Zimmerman, Véronique Dartois, Thomas Dick, Dereje A. Negatu

Synthesis and Testing of Analogs of the Tuberculosis Drug SQ109 Against Bacteria and Protozoa: Identification of Lead Compounds Against Mycobacterium abscessus and Malaria

ChemRxiv(2022)10.26434/chemrxiv-2022-xm94p

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0 citations

Satish R. Malwal, Nadine Álvarez, Zijun Gao, Mohammad Moniruzzaman, Svitlana Babii +28 more

Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections

Antimicrobial Agents and Chemotherapy(2023)10.1128/aac.01655-22

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25 citations

Wassihun Wedajo Aragaw, Julianna Cangialosi, Véronique Dartois, Thomas Dick, Dereje A. Negatu

Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus

Microbiology Spectrum(2023)10.1128/spectrum.02199-23

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18 citations

Wassihun Wedajo Aragaw, Véronique Dartois, Thomas Dick, Dereje A. Negatu

PROTAC antibiotics: the time is now

Expert Opinion on Drug Discovery(2023)10.1080/17460441.2023.2178413

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17 citations

Courtney C. Aldrich, Mei‐Lin Go, Thomas Dick, Jickky Palmae Sarathy

Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection

Antimicrobial Agents and Chemotherapy(2023)10.1128/aac.01459-22

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20 citations

Rubén González del Río, Mónica Cacho, David Barros-Aguirre, Joël Lelièvre, Joaquín Rullás +7 more

Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites

ACS Infectious Diseases(2023)10.1021/acsinfecdis.2c00537

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20 citations

Satish R. Malwal, Nadine Álvarez, Zijun Gao, Mohammad Moniruzzaman, Svitlana Babii +28 more

Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00009

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17 citations

Uday S. Ganapathy, Lea Mann, Rana Abdelaziz, Rüdiger W. Seidel, Richard Goddard +8 more

ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate

Antimicrobial Agents and Chemotherapy(2023)10.1128/aac.00381-23

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15 citations

Uday S. Ganapathy, Tian Lan, Paulina Osiecki, Jansy P. Sarathy, Véronique Dartois +3 more

Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2023)10.1128/aac.00717-23

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15 citations

Dereje A. Negatu, Christopher J. Bungard, Véronique Dartois, Abdellatif El Marrouni, Elliott Nickbarg +4 more

Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00398

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14 citations

Ben Mazurek, Ji-Hee Ko, Pujun Xie, Chikako Barnes, Christine Varvitsiotis +13 more

Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins

Microbiology Spectrum(2023)10.1128/spectrum.01900-23

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9 citations

Tian Lan, Véronique Dartois, Courtney C. Aldrich, Thomas Dick, Uday S. Ganapathy

Oral β-Lactam Pairs for the Treatment of Mycobacterium avium Complex Pulmonary Disease

The Journal of Infectious Diseases(2023)10.1093/infdis/jiad591

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8 citations

Sung Jae Shin, Su‐Young Kim, Byung Woo Jhun, Véronique Dartois, Thomas Dick +1 more

Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease

Nature Reviews Drug Discovery(2024)10.1038/s41573-024-00897-5

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108 citations

Thomas Dick, Véronique Dartois

Splenic marginal zone B cells restrict Mycobacterium tuberculosis infection by shaping the cytokine pattern and cell-mediated immunity

Cell Reports(2024)10.1016/j.celrep.2024.114426

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15 citations

Myo Minn Oo, Jih Hou Peh, Benjamin Chaik Meng Yeo, Ariel A. Aptekmann, Bernett Lee +6 more

Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations

Tuberculosis(2024)10.1016/j.tube.2024.102503

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23 citations

Tracey L. Bonfield, Jim P. Boyce, Charles L. Daley, Thomas Dick, Mercedes Gonzalez‐Juarrero +10 more

Toward better cures for Mycobacterium abscessus lung disease

Clinical Microbiology Reviews(2024)10.1128/cmr.00080-23

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18 citations

Thomas Dick, Véronique Dartois

Synthesis and in vitro Metabolic Stability of Sterically Shielded Antimycobacterial Phenylalanine Amides

ChemMedChem(2024)10.1002/cmdc.202300593

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8 citations

Uday S. Ganapathy, Lea Mann, Rüdiger W. Seidel, Richard Goddard, Frank Erdmann +3 more

Durlobactam to boost the clinical utility of standard of care β-lactams against Mycobacterium abscessus lung disease

Antimicrobial Agents and Chemotherapy(2024)10.1128/aac.01046-24

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7 citations

Wassihun Wedajo Aragaw, Tewodros Tariku Gebresilase, Sindhuja Paruchuri, Firat Kaya, Sung Jae Shin +4 more

Broad-Spectrum In Vitro Activity of Nα-Aroyl-N-Aryl-Phenylalanine Amides against Non-Tuberculous Mycobacteria and Comparative Analysis of RNA Polymerases

Antibiotics(2024)10.3390/antibiotics13050404

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3 citations

Uday S. Ganapathy, Rana Abdelaziz, Thomas Dick, Adrian Richter, Markus Lang

A pairwise approach to revitalize β-lactams for the treatment of TB

Antimicrobial Agents and Chemotherapy(2024)10.1128/aac.00034-24

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3 citations

Wassihun Wedajo Aragaw, Véronique Dartois, Thomas Dick, Dereje A. Negatu

Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2024)10.1128/aac.01051-24

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1 citations

Tewodros Tariku Gebresilase, Dereje A. Negatu, Véronique Dartois, Thomas Dick, Wassihun Wedajo Aragaw

Next-generation rifamycins for the treatment of mycobacterial infections

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2423842122

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13 citations

Tian Lan, Uday S. Ganapathy, Chui Fann Wong, Jickky Palmae Sarathy, Diana C. Jimenez +24 more

A potent phenylalkylamine disrupts mycobacterial membrane bioenergetics and augments bactericidal activity of bedaquiline

iScience(2025)10.1016/j.isci.2025.112915

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1 citations

Ming Li, Azhar Ali, Cedric Cheng Sheng Cheong, Kai Jie Goh, M Seto +8 more

Loss-of-Function Mutations in the Penicillin-Binding Protein PonA1 Confer Agar-Dependent Resistance to Durlobactam in Mycobacterium abscessus

Preprints.org(2025)10.20944/preprints202511.1728.v1

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0 citations

Wassihun Wedajo Aragaw, Min Xie, Véronique Dartois, Thomas Dick, Dereje A. Negatu