Arlene H. Sharpe

Also affiliated with Boston Biomedical Research Institute, Harvard University

MedicineImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 66 papers. Top paper: “Progressive immune dysfunction with advancing disease stage in renal cell carcinoma”.

Progressive immune dysfunction with advancing disease stage in renal cell carcinoma

Cancer Cell(2021)10.1016/j.ccell.2021.02.013

N/A

9.5DataRank · unranked

526 citations

Kelly Street, Kelly P. Burke, David L. Cookmeyer, Thomas Denize, Christina B. Pedersen +30 more

Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial

Nature Medicine(2023)10.1038/s41591-022-02181-8

N/A

4.9DataRank · unranked

192 citations

Jonathan Chen, Sherry Chao, Karin Pelka, Marios Giannakis, Julian M. Hess +40 more

B-cell-specific checkpoint molecules that regulate anti-tumour immunity

Nature(2023)10.1038/s41586-023-06231-0

N/A

4.1DataRank · unranked

171 citations

Yoon-Chul Kye, Jingwen Shi, Elena Torlai Triglia, Alexandra Schnell, Johannes Fessler +22 more

Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate

Nature Immunology(2022)10.1038/s41590-022-01129-x

N/A

2.1DataRank · unranked

83 citations

Joyce B. Kang, Aparna Nathan, Kristen E. Pauken, A. Helena Jonsson, Deepak A. Rao +4 more

Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition

Cancer Immunology Research(2022)10.1158/2326-6066.cir-21-0870

N/A

1.6DataRank · unranked

53 citations

Samuel C. Markson, Jackson H. Stocking, Naema Nayyar, Matt Lastrapes, Matthew R. Strickland +40 more

TCR-sequencing in cancer and autoimmunity: barcodes and beyond

Trends in Immunology(2022)10.1016/j.it.2022.01.002

N/A

1.4DataRank · unranked

54 citations

Kaitlyn A. Lagattuta, Benjamin Y. Lu, Liliana E. Lucca, Adil Daud, David A. Hafler +4 more

Neuropeptide signalling orchestrates T cell differentiation

Nature(2024)10.1038/s41586-024-08049-w

N/A

1.2DataRank · unranked

64 citations

Lin-Yu Sun, Martin W. LaFleur, Linglin Huang, Conner Lambden, Pratiksha I. Thakore +20 more

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

Nature Immunology(2024)10.1038/s41590-024-01961-3

N/A

1.0DataRank · unranked

43 citations

Amy Y. Huang, Megan E. Fung, Daniela Martínez, Chang-Yu Chen, Thomas J. LaSalle +20 more

Spatially organized multicellular immune hubs in human colorectal cancer

Cell(2021)10.1016/j.cell.2021.08.003

N/A

1.0DataRank · unranked

787 citations

Matan Hofree, Siranush Sarkizova, Joshua D. Pirl, Vjola Jorgji, Alborz Bejnood +73 more

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Cell(2020)10.1016/j.cell.2020.11.009

N/A

0.990DataRank · unranked

735 citations

Jefte M. Drijvers, Gregory J. Baker, Alessia Catozzi, Juan Carlos García‐Cañaveras, Brandon M. Gassaway +17 more

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.30.426796

N/A

0.297DataRank · unranked

4 citations

Matan Hofree, Jonathan Chen, Siranush Sarkizova, Joshua D. Pirl, Vjola Jorgji +71 more

Stratified analysis identifies HIF-2 α as a therapeutic target for highly immune-infiltrated melanomas

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.29.620300

N/A

0.231DataRank · unranked

3 citations

Kelly P. Burke, Ryan Porter, Lynn Meiger, Peter Fatouros, Jiekun Yang +24 more

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.30.294959

N/A

0DataRank · unranked

4 citations

Osmaan Shahid, Kaitlyn A. Lagattuta, Kelly M. Mahuron, Jacob M. Luber, Margaret M. Lowe +16 more

Immunogenomic characterization of advanced clear cell renal cell carcinoma treated with PD-1 blockade.

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.15_suppl.5010

N/A

0DataRank · unranked

2 citations

Yue Hou, Ziad Bakouny, Miriam Ficial, Miriam Sant’Angelo, Petra Ross‐Macdonald +15 more

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

UNC Libraries(2020)10.17615/2vfb-gr51

N/A

0DataRank · unranked

0 citations

Gordon J. Freeman, Victor Tkachev, Catarina Sacristán, Ian A. Blair, Govindarajan Thangavelu +30 more

The aging lung: Physiology, disease, and immunity

Cell(2021)10.1016/j.cell.2021.03.005

N/A

0DataRank · unranked

483 citations

Jared H. Rowe, Carolina Garcia-de-Alba, Carla F. Kim, Arlene H. Sharpe, Marcia C. Haigis +1 more

Emerging concepts in PD-1 checkpoint biology

Seminars in Immunology(2021)10.1016/j.smim.2021.101480

N/A

0DataRank · unranked

186 citations

James A. Torchia, Apoorvi Chaudhri, Arlene H. Sharpe, Gordon J. Freeman, Kristen E. Pauken

Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

Nature Immunology(2021)10.1038/s41590-021-00949-7

N/A

0DataRank · unranked

241 citations

Sarah A. Weiss, Kristen E. Pauken, Debattama R. Sen, Arlene H. Sharpe, Jenna L. Collier

Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms

Journal of Clinical Investigation(2021)10.1172/jci145186

N/A

0DataRank · unranked

221 citations

Andrew H. Lichtman, Arlene H. Sharpe, Lorenzo Galluzzi, Richard N. Kitsis, Javid J. Moslehi

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

Science Translational Medicine(2021)10.1126/scitranslmed.abd8636

N/A

0DataRank · unranked

97 citations

Masayoshi Kawakubo, Vikram R. Juneja, Mack Y. Su, Tal Hadad Erlich, Martin W. LaFleur +32 more

Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage

Science Immunology(2021)10.1126/sciimmunol.abe3702

N/A

0DataRank · unranked

92 citations

Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai +23 more

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma

Frontiers in Immunology(2021)10.3389/fimmu.2021.733136

N/A

0DataRank · unranked

27 citations

Benjamin P. Hurrell, Doumet Georges Helou, Christine Quach, Jacob D. Painter, Pedram Shafiei-Jahani +6 more

Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms

JCI Insight(2021)10.1172/jci.insight.142909

N/A

0DataRank · unranked

25 citations

Naoka Murakami, Isadora T. Lape, Rodrigo Benedetti Gassen, Kaifeng Liu, Songjie Cai +12 more

A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells

Immunity(2021)10.1016/j.immuni.2021.08.029

N/A

0DataRank · unranked

20 citations

Kate M. Vignali, Andrea L. Szymczak-Workman, Amanda R. Burton, Erin A. Brunazzi, Shin Foong Ngiow +7 more

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.25.456956

N/A

0DataRank · unranked

0 citations

Samuel C. Markson, Jackson H. Stocking, Naema Nayyar, Matthew Lastrapes, Matthew R. Strickland +39 more

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

Cell Metabolism(2022)10.1016/j.cmet.2022.06.008

N/A

0DataRank · unranked

348 citations

Jared H. Rowe, Sheila Johnson, Shakchhi Joshi, Giulia Notarangelo, Kiran Kurmi +5 more

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Nature(2022)10.1038/s41586-022-05257-0

N/A

0DataRank · unranked

326 citations

Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn Kissick +26 more

Age-associated remodeling of T cell immunity and metabolism

Cell Metabolism(2022)10.1016/j.cmet.2022.11.005

N/A

0DataRank · unranked

181 citations

Peter Georgiev, Alison E. Ringel, Arlene H. Sharpe, Marcia C. Haigis, SeongJun Han

When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer

Science Advances(2022)10.1126/sciadv.abj3286

N/A

0DataRank · unranked

102 citations

Marie Marotel, Jonathan J. Hodgins, Elisabetta Vulpis, Olivia Makinson, Sara Asif +18 more

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability

Nature Communications(2022)10.1038/s41467-022-32899-5

N/A

0DataRank · unranked

42 citations

Doumet Georges Helou, Emily Howard, Jacob D. Painter, Pedram Shafiei-Jahani, Arlene H. Sharpe +2 more

Gata6+ resident peritoneal macrophages promote the growth of liver metastasis

Nature Communications(2022)10.1038/s41467-022-32080-y

N/A

0DataRank · unranked

41 citations

Raymond Shim, Woo‐Yong Lee, Arlene H. Sharpe, Paul Kubes, Mokarram Hossain

Inactivation of Ebola Virus and SARS-CoV-2 in Cell Culture Supernatants and Cell Pellets by Gamma Irradiation

Viruses(2022)10.3390/v15010043

N/A

0DataRank · unranked

5 citations

Scott Seitz, Emily F. Gaudiano, J. J. Patten, Patrick T. Keiser, John H. Connor +3 more

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.28.497997

N/A

0DataRank · unranked

0 citations

Sampurna Chatterjee, Elizabeth M. Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette +19 more

CRISPR screens reveal neuropeptide signaling orchestrates T helper cell differentiation

Research Square(2022)10.21203/rs.3.rs-1953978/v1

N/A

0DataRank · unranked

0 citations

Yu Hou, Martin W. LaFleur, Linglin Huang, Conner Lambden, Pratiksha I. Thakore +14 more

1038 Loss of PD-1 signals improves CD8+ TIL function in a cell intrinsic and cell extrinsic manner

Regular and Young Investigator Award Abstracts(2022)10.1136/jitc-2022-sitc2022.1038

N/A

0DataRank · unranked

0 citations

Kristen E. Pauken, Vikram R. Juneja, Osmaan Shahid, Kelly P. Burke, Jared H. Rowe +9 more

Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance

Nature(2023)10.1038/s41586-023-06026-3

N/A

0DataRank · unranked

187 citations

Francesca S. Gazzaniga, Meng–Huang Wu, Amalia K. Luthens, Jacob E. Gillis, Wenfeng Zheng +11 more

Immune checkpoint receptors in autoimmunity

Current Opinion in Immunology(2023)10.1016/j.coi.2023.102283

N/A

0DataRank · unranked

65 citations

Dillon G. Patterson, Dan Liang, Arlene H. Sharpe, Kelly P. Burke

Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Cancer Discovery(2023)10.1158/2159-8290.cd-22-1301

N/A

0DataRank · unranked

52 citations

Ilaria Elia, Osmaan Shahid, Emily F. Gaudiano, Natalia E. Sifnugel, Sheila Johnson +11 more

Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis

Molecular Cell(2023)10.1016/j.molcel.2023.03.023

N/A

0DataRank · unranked

43 citations

Joon Seok Park, Kiran Kurmi, Songhua Hu, Giulia Notarangelo, Joseph M. Crowley +5 more

Regulatory T cells in dominant immunologic tolerance

Journal of Allergy and Clinical Immunology(2023)10.1016/j.jaci.2023.09.025

N/A

0DataRank · unranked

38 citations

Mehdi Benamar, SeongJun Han, Marcia C. Haigis, Arlene H. Sharpe, Talal A. Chatila +1 more

PD-1 Expression on Intratumoral Regulatory T Cells Is Associated with Lack of Benefit from Anti–PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-23-2274

N/A

0DataRank · unranked

37 citations

Opeyemi A. Jegede, Sayed Matar, Nourhan El Ahmar, Destiny J. West, Emily Walton +16 more

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

The Journal of Experimental Medicine(2023)10.1084/jem.20221920

N/A

0DataRank · unranked

30 citations

Kristen E. Pauken, Catherine Lee, Dillon G. Patterson, Samuel C. Markson, Thomas S. Conway +7 more

Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy

Experimental & Molecular Medicine(2023)10.1038/s12276-023-01075-0

N/A

0DataRank · unranked

22 citations

Francesca S. Gazzaniga, Dennis L. Kasper, Arlene H. Sharpe, Joon Seok Park

X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system

Nature Immunology(2023)10.1038/s41590-023-01689-6

N/A

0DataRank · unranked

13 citations

Ashlyn M. Lemmen, Ivy S. L. Streeter, Thao H. Nguyen, Lauren E. Milling, Nicole M. Derosia +11 more

Metabolic modulation of mitochondrial mass during CD4+ T cell activation

Cell chemical biology(2023)10.1016/j.chembiol.2023.08.008

N/A

0DataRank · unranked

10 citations

Dan Liang, Robert van de Ven, Peter Georgiev, Brandon M. Gassaway, SeongJun Han +15 more

Tracking tumor-specific CD8+ T cell responses

Trends in Immunology(2023)10.1016/j.it.2023.03.012

N/A

0DataRank · unranked

3 citations

Samuel C. Markson, Arlene H. Sharpe, Kelly P. Burke

Data from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

(2023)10.1158/2326-6066.c.6550425.v1

N/A

0DataRank · unranked

0 citations

Jacob E. Gillis, Tara Muijlwijk, Thao H. Nguyen, Emily F. Gaudiano, Isaac S. Harris +9 more

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

Cell(2024)10.1016/j.cell.2024.07.016

N/A

0DataRank · unranked

244 citations

Samuel C. Butler, Jian Cui, Anthony R. Cillo, Carly Cardello, Chang Liu +15 more

The B7:CD28 family and friends: Unraveling coinhibitory interactions

Immunity(2024)10.1016/j.immuni.2024.01.013

N/A

0DataRank · unranked

120 citations

Apoorvi Chaudhri, Gordon J. Freeman, Arlene H. Sharpe, Kelly P. Burke

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

Cell(2024)10.1016/j.cell.2024.07.018

N/A

0DataRank · unranked

100 citations

Sasikanth Manne, Yinghui Huang, Tarek Azar, Zeyu Chen, Divij Mathew +15 more

Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche

Science Immunology(2024)10.1126/sciimmunol.adh0152

N/A

0DataRank · unranked

79 citations

Victoire Gouirand, Courtney E. Macon, Margaret M. Lowe, Ian C. Boothby, J. Moreau +7 more

Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Cancer Immunology Research(2024)10.1158/2326-6066.cir-24-0463

N/A

0DataRank · unranked

22 citations

SeongJun Han, Amy Y. Huang, Thao H. Nguyen, Jefte M. Drijvers, Hannah Creasey +15 more

Single-Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T-cell Subpopulation That Is Correlated with Response to Checkpoint Therapy in Melanoma

Cancer Research(2025)10.1158/0008-5472.can-23-3918

N/A

0DataRank · unranked

11 citations

Osmaan Shahid, Prachi Sao, Clinton Wu, Alexandra M. Haugh, Laura A. Huppert +13 more

PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion

The Journal of Experimental Medicine(2025)10.1084/jem.20230542

N/A

0DataRank · unranked

6 citations

Samuel C. Markson, Thomas S. Conway, Vikram R. Juneja, Osmaan Shahid, Kelly P. Burke +13 more

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

eLife(2025)10.7554/elife.107745

N/A

0DataRank · unranked

0 citations

Sheila Johnson, Kiran Kurmi, Song-Hua Hu, SeongJun Han, Dillon G. Patterson +10 more

Author Correction: B-cell-specific checkpoint molecules that regulate anti-tumour immunity

Nature(2025)10.1038/s41586-025-08858-7

N/A

0DataRank · unranked

0 citations

Yoon-Chul Kye, Jingwen Shi, Elena Torlai Triglia, Alexandra Schnell, Johannes Fessler +22 more

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Cancer Immunology Research(2020)10.1158/2326-6066.cir-20-0384

N/A

0DataRank · unranked

180 citations

Jacob E. Gillis, Tara Muijlwijk, Thao H. Nguyen, Emily F. Gaudiano, Isaac S. Harris +9 more

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

Clinical Cancer Research(2020)10.1158/1078-0432.ccr-20-2291

N/A

0DataRank · unranked

175 citations

Prafulla C. Gokhale, Maria C. Speranza, Benjamin K. Eschle, Michael J. Poitras, Margaret K. Wilkens +18 more

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

Nature Communications(2020)10.1038/s41467-020-17813-1

N/A

0DataRank · unranked

174 citations

Pedram Shafiei-Jahani, Richard Lo, Emily Howard, Benjamin P. Hurrell, Lauriane Galle-Treger +6 more

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

The Journal of Experimental Medicine(2020)10.1084/jem.20182232

N/A

0DataRank · unranked

262 citations

Juhi R. Kuchroo, Peter T. Sage, Dan Liang, Loise M. Francisco, Jessica N. Buck +13 more

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

Cell Reports(2020)10.1016/j.celrep.2020.107827

N/A

0DataRank · unranked

132 citations

Jernej Godec, Pamela M. Odorizzi, Keturah Brown, Kathleen B. Yates, Shin Foong Ngiow +11 more

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

The Journal of Experimental Medicine(2020)10.1084/jem.20200920

N/A

0DataRank · unranked

127 citations

Osmaan Shahid, Kaitlyn A. Lagattuta, Kelly M. Mahuron, Jacob M. Luber, Margaret M. Lowe +16 more

The multifaceted functions of follicular regulatory T cells

Current Opinion in Immunology(2020)10.1016/j.coi.2020.10.009

N/A

0DataRank · unranked

72 citations

Arlene H. Sharpe, Peter T. Sage

Understanding adverse events of immunotherapy: A mechanistic perspective

The Journal of Experimental Medicine(2020)10.1084/jem.20192179

N/A

0DataRank · unranked

47 citations

Stephanie Grebinoski, Arlene H. Sharpe, Dario A.A. Vignali, Kelly P. Burke

The effects of age and systemic metabolism on anti-tumor T cell responses

eLife(2020)10.7554/elife.62420

N/A

0DataRank · unranked

67 citations

Arlene H. Sharpe, Marcia C. Haigis, Jefte M. Drijvers

Evaluation of predictive biomarkers for nivolumab in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC) from the CheckMate-025 (CM-025) trial.

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.15_suppl.5023

N/A

0DataRank · unranked

12 citations

Opeyemi A. Jegede, Miriam Sant’Angelo, Sonia Moreno, David A. Braun, Megan Wind‐Rotolo +15 more