David Sinclair

Also affiliated with Imense (United Kingdom), Center for Human Genetics, Boston VA Research Institute, Hebrew SeniorLife

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.13.694109

Top 100%

0DataRank

Top 100%0 citations

Shyleen Frost, Patrick Griffin, Maeve S. McNamara, David Sinclair, Alice E. Kane +1 more

Papers

Driven by 39 papers — median percentile 0. Top paper: “Reprogramming to recover youthful epigenetic information and restore vision”.

Reprogramming to recover youthful epigenetic information and restore vision

Nature(2020)10.1038/s41586-020-2975-4

N/A

7.8DataRank · unranked

843 citations

Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang +24 more

Why does COVID-19 disproportionately affect older people?

Aging(2020)10.18632/aging.103344

N/A

1.1DataRank · unranked

1157 citations

Maeve S. McNamara, David Sinclair, Amber L. Mueller

Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila

eLife(2022)10.7554/elife.82709

N/A

0.452DataRank · unranked

10 citations

Berrak Uğur, Israel Pichardo‐Casas, Jordan Rabasco, Felipe Escobedo, Zhongyuan Zuo +6 more

Invigorating discovery and clinical translation of aging biomarkers

Nature Aging(2025)10.1038/s43587-025-00838-w

N/A

0.330DataRank · unranked

6 citations

Chiara Herzog, Kejun Ying, Alan Tomusiak, Jessica Kasamoto, Raghav Sehgal +41 more

SIRT2 transgenic over‐expression does not impact lifespan in mice

Aging Cell(2023)10.1111/acel.14027

N/A

0.305DataRank · unranked

4 citations

Corrine E. Fiveash, Nicholas L. Bentley, Myung‐Jin Kang, Hemna Govindaraju, Jayne A. Barbour +16 more

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

International Journal of Molecular Sciences(2020)10.3390/ijms21144896

N/A

0DataRank · unranked

4 citations

João A. Amorim, Ivo F. Machado, Ana C. Castela, Clemens Steegborn, David Sinclair +3 more

Why Does COVID-19 Disproportionately Affect the Elderly?

Preprints.org(2020)10.20944/preprints202004.0548.v1

N/A

0DataRank · unranked

29 citations

Maeve S. McNamara, David Sinclair, Amber L. Mueller

Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.01.182485

N/A

0DataRank · unranked

0 citations

Berrak Uğur, Israel Pichardo‐Casas, Jorden Rabasco, Felipe Escobedo, Zhongyuan Zuo +6 more

Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice

Nutrients(2021)10.3390/nu13093290

N/A

0DataRank · unranked

25 citations

Sarah J. Mitchell, Michael R. MacArthur, Alice E. Kane, David Sinclair, Emily M. Venable +6 more

Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung

Frontiers in Oncology(2021)10.3389/fonc.2020.602763

N/A

0DataRank · unranked

18 citations

Yafeng Zhu, Benoît Petit, Ron Leavitt, Mike Warn, Erich Giedzinski +5 more

TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.25.465725

N/A

0DataRank · unranked

12 citations

Alice E. Kane, Alexandre Trapp, Jien Li, Matthew Arnold, Jesse R. Poganik +17 more

Gut Microbiota predicts Healthy Late-life Aging in Male Mice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.22.449472

N/A

0DataRank · unranked

3 citations

Sarah J. Mitchell, Michael R. MacArthur, Alice E. Kane, David Sinclair, Emily M. Venable +6 more

Novel feature selection methods for construction of accurate epigenetic clocks

PLoS Computational Biology(2022)10.1371/journal.pcbi.1009938

N/A

0DataRank · unranked

18 citations

Amber L. Mueller, Bradley English, Anthony Arena, Daniel L. Vera, Alice E. Kane +2 more

Meeting Report: Aging Research and Drug Discovery

Aging(2022)10.18632/aging.203859

N/A

0DataRank · unranked

6 citations

Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur +73 more

Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy

The Journals of Gerontology Series A(2022)10.1093/gerona/glac067

N/A

0DataRank · unranked

6 citations

Alice E. Kane, Susan E. Howlett, David Sinclair, Sarah N. Hilmer, John Mach

International Gains to Achieving Healthy Longevity

Cold Spring Harbor Perspectives in Medicine(2022)10.1101/cshperspect.a041202

N/A

0DataRank · unranked

7 citations

Julian Ashwin, Martin Ellison, David Sinclair, Andrew Scott

Loss of epigenetic information as a cause of mammalian aging

Cell(2023)10.1016/j.cell.2022.12.027

N/A

0DataRank · unranked

627 citations

Motoshi Hayano, Patrick Griffin, João A. Amorim, Michael S. Bonkowski, John K. Apostolides +59 more

Chemically induced reprogramming to reverse cellular aging

Aging(2023)10.18632/aging.204896

N/A

0DataRank · unranked

134 citations

Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Y. Maybury‐Lewis +13 more

The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors

Ageing Research Reviews(2023)10.1016/j.arr.2023.101939

N/A

0DataRank · unranked

69 citations

Bonnie Wong, Mark C. Eldaief, Daniel Z. Press, David Sinclair, Giacomo Koch +3 more

Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming

Nature Aging(2023)10.1038/s43587-023-00539-2

N/A

0DataRank · unranked

53 citations

Mahdi Moqri, Sun Y. Maybury‐Lewis, Ryan Rogers-Hammond, Tineke Anna de Jong, Alexander S. Parker +5 more

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study

The Journal of Clinical Endocrinology & Metabolism(2023)10.1210/clinem/dgad027

N/A

0DataRank · unranked

48 citations

Rodrigo J. Valderrábano, Benjamin Wipper, Ariela R. Orkaby, Kieran F. Reid, Thomas W. Storer +17 more

Restricting mealtime ameliorates neurodegeneration

Cell Metabolism(2023)10.1016/j.cmet.2023.09.006

N/A

0DataRank · unranked

3 citations

David Sinclair, Xiao Tian

Cellular rejuvenation protects neurons from inflammation mediated cell death

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.30.560301

N/A

0DataRank · unranked

5 citations

Abdulshakour Mohammadnia, Kali Heale, Adam M.R. Groh, Elizabeth M.-L. Hua, Aliyah Zaman +7 more

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Aging(2024)10.18632/aging.206135

N/A

0DataRank · unranked

42 citations

Qiang Fu, Dominika Wilczok, Kejun Ying, Aaron A. King, Adam Antebi +95 more

Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder

Translational Psychiatry(2024)10.1038/s41398-024-02833-y

N/A

0DataRank · unranked

17 citations

Charlotte Stiplosek, Sinead M. O’Donovan, David Sinclair, Kathleen A. Grant, Ratna Bollavarapu +5 more

Sex dimorphism and tissue specificity of gene expression changes in aging mice

Biology of Sex Differences(2024)10.1186/s13293-024-00666-4

N/A

0DataRank · unranked

14 citations

Matt Arnold, Brady Samuelson, Judy Wu, Amber L. Mueller, David Sinclair +2 more

Response to: The information theory of aging has not been tested

Cell(2024)10.1016/j.cell.2024.01.014

N/A

0DataRank · unranked

5 citations

Motoshi Hayano, Luis A. Rajman, David Sinclair, Jae-Hyun Yang

Cellular rejuvenation protects neurons from inflammation-mediated cell death

Cell Reports(2025)10.1016/j.celrep.2025.115298

N/A

0DataRank · unranked

19 citations

Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, Adam M.R. Groh +10 more

Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice

Circulation Research(2025)10.1161/circresaha.124.324909

N/A

0DataRank · unranked

11 citations

Emily Waigi, Vi Nguyen, Ahmed Dawood Mohammed, Tiago J. Costa, Milene Tavares Fontes +11 more

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice

npj Aging(2025)10.1038/s41514-025-00237-w

N/A

0DataRank · unranked

3 citations

Judy Wu, Patrick Griffin, Brady Samuelson, David Sinclair, Alice E. Kane +1 more

Multiomic clocks to predict phenotypic age in mice

The Journals of Gerontology Series A(2025)10.1093/gerona/glaf188

N/A

0DataRank · unranked

2 citations

Patrick Griffin, David Leigh, Jason Kras, Enrique Ramos, Isaac Bishof +6 more

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.22.634160

N/A

0DataRank · unranked

0 citations

Judy Wu, Patrick R. Griffin, Brady Samuelson, David Sinclair, Alice E. Kane +1 more

Mitochondrial Dysfunction Induces Hepatic Lipid Accumulation and Inflammatory Responses in mtDNA Mutator Mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.25.650453

N/A

0DataRank · unranked

0 citations

Angela Kim, Kayla Berthod, Rui Mamede-Branca, Maria Olin, Israel Pichardo‐Casas +6 more

Multiomic clocks to predict phenotypic age in mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.30.651114

N/A

0DataRank · unranked

0 citations

Patrick Griffin, David Leigh, Jason Kras, Enrique Ramos, Isaac Bishof +6 more

DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.13.694109

Top 100%

0DataRank

Top 100%0 citations

Shyleen Frost, Patrick Griffin, Maeve S. McNamara, David Sinclair, Alice E. Kane +1 more

Age and life expectancy clocks based on machine learning analysis of mouse frailty

Nature Communications(2020)10.1038/s41467-020-18446-0

N/A

0DataRank · unranked

134 citations

Alice E. Kane, Sarah J. Mitchell, Michael R. MacArthur, Elisa Warner, David S. Vogel +5 more

ARDD 2020: from aging mechanisms to interventions

Aging(2020)10.18632/aging.202454

N/A

0DataRank · unranked

57 citations

Kotb Abdelmohsen, Pénélope A. Andreux, Ieva Bagdonaite, Nir Barzilai, Søren Brunak +61 more

Tumor Necrosis Factor-Alpha Signaling May Contribute to Chronic West Nile Virus Post-infectious Proinflammatory State

Frontiers in Medicine(2020)10.3389/fmed.2020.00164

N/A

0DataRank · unranked

31 citations

Marie Grill, Brent P. Goodman, Syed B. Sadiq, David Sinclair, P. J. S. Vig +2 more

Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet

The Journals of Gerontology Series A(2020)10.1093/gerona/glaa148

N/A

0DataRank · unranked

24 citations

Robin K. Minor, Sarah J. Mitchell, Hector H. Palacios, Jordan J. Licata, Theresa M. Ward +9 more

David Sinclair

Indexed papers

Top data-sharing exemplar

Papers