Barry R. O’Keefe

Also affiliated with Tochigi Cancer Center, Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research

Immunology and MicrobiologyMedicineBiochemistry, Genetics and Molecular BiologyChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

3.7Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Creating and screening natural product libraries

Natural Product Reports(2020)10.1039/c9np00068b

Top 6%

3.7DataRank

Top 6%154 citations

Christopher C. Thornburg, Curtis J. Henrich, Tanja Grkovic, Barry R. O’Keefe, Brice A. P. Wilson

Papers

Driven by 48 papers — median percentile 94. Top paper: “Creating and screening natural product libraries”.

Creating and screening natural product libraries

Natural Product Reports(2020)10.1039/c9np00068b

Top 6%

3.7DataRank

Top 6%154 citations

Christopher C. Thornburg, Curtis J. Henrich, Tanja Grkovic, Barry R. O’Keefe, Brice A. P. Wilson

Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel

PLOS ONE(2022)10.1371/journal.pone.0261775

N/A

0.520DataRank · unranked

31 citations

Marla J. Keller, José A. Fernández Romero, Barbara A. Friedland, George W. Creasy, Marlena G. Plagianos +25 more

Molecular genomic features associated with in vitro response of the NCI‐60 cancer cell line panel to natural products

Molecular Oncology(2020)10.1002/1878-0261.12849

N/A

0.510DataRank · unranked

29 citations

Simarjeet Negi, Laura M. Yee, Jason R. Evans, Tanja Grkovic, Alida Palmisano +6 more

Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases

Journal of Natural Products(2023)10.1021/acs.jnatprod.3c00394

N/A

0.360DataRank · unranked

10 citations

Brice A. P. Wilson, Ning Li, Rohan Shah, Masoumeh Dalilian, Dongdong Wang +6 more

Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108274

N/A

0.217DataRank · unranked

3 citations

Huanchen Wang, Haibo Zhang, Isabel Prucker, Lalith Perera, Ekaterina I. Goncharova +8 more

An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures

Journal of Natural Products(2020)10.1021/acs.jnatprod.0c00946

N/A

0DataRank · unranked

13 citations

Huiyun Liang, Shengxin Cai, Barry R. O’Keefe, Susan L. Mooberry, Robert H. Cichewicz +1 more

Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods

Phytochemistry(2020)10.1016/j.phytochem.2020.112278

N/A

0DataRank · unranked

10 citations

Brice A. P. Wilson, Curtis J. Henrich, Karen Wendt, Jarrod B. King, Robert H. Cichewicz +5 more

Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea

Journal of Natural Products(2020)10.1021/acs.jnatprod.0c00423

N/A

0DataRank · unranked

27 citations

Shengxin Cai, Chase M. Carver, Douglas R. Powell, April L. Risinger, Tanja Grkovic +4 more

(−)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata , Induces DNA Double-Strand Breaks

INDIGO (University of Illinois at Chicago)(2020)10.17615/q9er-ps90

N/A

0DataRank · unranked

4 citations

Yuki Suzuki, David Newman, Barry R. O’Keefe, Yohei Saito, Kyoko Nakagawa‐Goto +2 more

Acetophenone Monomers from Acronychia trifoliolata

INDIGO (University of Illinois at Chicago)(2020)10.17615/9ph9-3674

N/A

0DataRank · unranked

1 citations

Susan L. Morris‐Natschke, Airi Suzuki, David Newman, Kyoko Nakagawa‐Goto, Kuo‐Hsiung Lee +4 more

Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge Neopetrosia sp.

Organic Letters(2021)10.1021/acs.orglett.1c00743

N/A

0DataRank · unranked

18 citations

Wei Jiang, Chang‐Kwon Kim, Heidi R. Bokesch, Girma M. Woldemichael, Berkley E. Gryder +6 more

Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential

Cancers(2021)10.3390/cancers13112834

N/A

0DataRank · unranked

18 citations

Thilini Peramuna, Shengxin Cai, Leila Takahashi‐Ruiz, Jacob Nathaniel Essif, Corena V. Grant +5 more

Sinularamides A–G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a Sinularia sp. Soft Coral

Journal of Natural Products(2021)10.1021/acs.jnatprod.1c00367

N/A

0DataRank · unranked

7 citations

Dongdong Wang, Brice A. P. Wilson, Donna Voeller, Heidi R. Bokesch, Emily A. Smith +4 more

Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana

Marine Drugs(2021)10.3390/md19070361

N/A

0DataRank · unranked

12 citations

Dongdong Wang, Brice A. P. Wilson, Unwoo Kang, Heidi R. Bokesch, Emily A. Smith +7 more

In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors

SLAS DISCOVERY(2021)10.1177/24725552211000675

N/A

0DataRank · unranked

6 citations

Donna Voeller, Emily A. Smith, Antony Wamiru, Ekaterina I. Goncharova, Gang Liu +3 more

Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs

Structure(2021)10.1016/j.str.2021.03.010

N/A

0DataRank · unranked

0 citations

Barry R. O’Keefe, Girma M. Woldemichael

Photochemical Dimerization of Plakinidine B Leads to Potent Inhibition of the E3 Ubiquitin-Protein Ligase CBL-B

Organic Letters(2022)10.1021/acs.orglett.2c03922

N/A

0DataRank · unranked

9 citations

Dong‐Hao Li, Brice A. P. Wilson, Kalina Ranguelova, Masoumeh Dalilian, Emily A. Smith +9 more

Physicochemical characterization of the recombinant lectin scytovirin and microbicidal activity of the SD1 domain produced in rice against HIV-1

Plant Cell Reports(2022)10.1007/s00299-022-02834-5

N/A

0DataRank · unranked

3 citations

Amaya Blanco-Perera, Shilpa R. Shenoy, Yi Eve Sun, Sílvia Marfil, Jordana Muñoz‐Basagoiti +7 more

KDM3B inhibitors disrupt PAX3-FOXO1 oncogenic activity in fusion positive rhabdomyosarcoma.

Research Square(2022)10.21203/rs.3.rs-2298627/v1

N/A

0DataRank · unranked

0 citations

Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud +26 more

Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library

ACS Infectious Diseases(2023)10.1021/acsinfecdis.3c00067

N/A

0DataRank · unranked

32 citations

S J Ryan Arends, Vítor F. Freire, Jason R. Evans, Sean DeVries, Brian D. Peyser +11 more

Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2214561120

N/A

0DataRank · unranked

19 citations

Fábio Luís Lima Monteiro, Lauren R. H. Krumpe, Victoria Armario-Nájera, Shilpa R. Shenoy, Daniel Perez‐Zsolt +26 more

Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein

Biochemistry(2023)10.1021/acs.biochem.3c00109

N/A

0DataRank · unranked

12 citations

Farah Fazloon Hassen, Gabriela Canziani, Praneeta Bandi, Choya Talukder, Fengwen Zhang +9 more

National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks

ACS Omega(2023)10.1021/acsomega.2c07416

N/A

0DataRank · unranked

9 citations

Rhone K. Akee, Shaurya Chanana, Grant D. McConachie, Christopher C. Thornburg, Tanja Grkovic +2 more

An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics

New Biotechnology(2023)10.1016/j.nbt.2023.04.003

N/A

0DataRank · unranked

11 citations

Max Z. Levine, Lauren R. H. Krumpe, Jennifer A. Wilson, Curtis J. Henrich, Barry R. O’Keefe +12 more

Biochemical Discovery, Intracellular Evaluation, and Crystallographic Characterization of Synthetic and Natural Product Adenosine 3′,5′-Cyclic Monophosphate-Dependent Protein Kinase A (PKA) Inhibitors

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.3c00010

N/A

0DataRank · unranked

5 citations

Ning Li, Juliana A. Martinez Fiesco, Masoumeh Dalilian, Dongdong Wang, Emily A. Smith +8 more

Rare Caulamidine Hexacyclic Alkaloids from the Marine Ascidian Polyandrocarpa sp.

Journal of Natural Products(2023)10.1021/acs.jnatprod.3c00393

N/A

0DataRank · unranked

5 citations

Dongdong Wang, Wei Jiang, Heidi R. Bokesch, Brice A. P. Wilson, Barry R. O’Keefe +2 more

Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein

ChemRxiv(2023)10.26434/chemrxiv-2023-2ng8k

N/A

0DataRank · unranked

0 citations

Farah Fazloon Hassen, Gabriela Canziani, Praneeta Bandi, Choya Talukder, Fengwen Zhang +9 more

Natural Products as a Source of Chemical Diversity in cyclic-AMP dependent Protein Kinase A (PKA) Inhibitor Discovery

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.521340

N/A

0DataRank · unranked

0 citations

Ning Li, Juliana Martinez Fiesco, Masoumeh Dalilian, Dongdong Wang, Sarath P. D. Senadeera +10 more

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

Nature Communications(2024)10.1038/s41467-024-45902-y

N/A

0DataRank · unranked

18 citations

Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud +27 more

Acroamine A, a 2-Amino Adenine Alkaloid from the Marine Soft Coral Acrozoanthus australiae and Its Semisynthetic Derivatives That Inhibit cAMP-Dependent Protein Kinase A Catalytic Subunit Alpha

Journal of Natural Products(2024)10.1021/acs.jnatprod.4c00477

N/A

0DataRank · unranked

6 citations

Dongdong Wang, Brice A. P. Wilson, Emily A. Smith, Antony Wamiru, Juliana A. Martinez Fiesco +5 more

Antimicrobial bianthrones from the crinoid Heterometra sp.

RSC Advances(2024)10.1039/d4ra05594b

N/A

0DataRank · unranked

4 citations

Lucero Martínez-Fructuoso, Rohitesh Kumar, Rhone K. Akee, Christopher C. Thornburg, Susan M. Ensel +7 more

Chemoreactive 2,5-Diketopiperazines from a Penicillium sp., Structure Revision of Reported Analogues and Proposed Facile Transformation Pathways

Journal of Natural Products(2024)10.1021/acs.jnatprod.4c00478

N/A

0DataRank · unranked

7 citations

Emily A. Smith, Karen Wendt, Masoumeh Dalilian, Ekaterina I. Goncharova, Isaac Brownell +6 more

Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues

Chemical Science(2024)10.1039/d4sc01976h

N/A

0DataRank · unranked

4 citations

Lauren R. H. Krumpe, Colton D. Payne, Victoria G. Klein, Barry R. O’Keefe, Richard J. Clark +3 more

MoMo30 Binds to SARS-CoV-2 Spike Variants and Blocks Infection by SARS-CoV-2 Pseudovirus

Viruses(2024)10.3390/v16091433

N/A

0DataRank · unranked

2 citations

Mahfuz Khan, Morgan I. Coleman, Vincent C. Bond, Virginia Floyd, Erick Gbodossou +5 more

Structure elucidation, absolute configuration, and biological evaluation of cyclic peroxides from the sponge Plakinastrella sp.

Bioorganic & Medicinal Chemistry Letters(2024)10.1016/j.bmcl.2024.129963

N/A

0DataRank · unranked

2 citations

Rhone K. Akee, Lucero Martínez-Fructuoso, Vítor F. Freire, Christopher C. Thornburg, Jason R. Evans +5 more

Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy

Antimicrobial Agents and Chemotherapy(2024)10.1128/aac.01194-24

N/A

0DataRank · unranked

2 citations

Sunna Nabeela, Christopher C. Thornburg, Tanja Grkovic, Priya Uppuluri, Luke Whitesell +4 more

New Discorhabdin D Analogues from Latrunculia spp. Sponges

Journal of Natural Products(2024)10.1021/acs.jnatprod.4c01036

N/A

0DataRank · unranked

2 citations

Masoumeh Dalilian, Lin Du, Cindy H. Chau, William D. Figg, Barry R. O’Keefe +2 more

DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens

npj Precision Oncology(2025)10.1038/s41698-025-01111-4

N/A

0DataRank · unranked

2 citations

Neelam Sinha, Marlenne Perales, Adi V Tarrab, Trinh Nguyen, Lihe Liu +16 more

Identification of Cembrane Diterpenoids from Sinularia sp. That Reduce the Viability of Diffuse Pleural Mesothelioma Cell Lines

Journal of Natural Products(2025)10.1021/acs.jnatprod.5c00786

N/A

0DataRank · unranked

1 citations

Anam Fatima Shaikh, Dongdong Wang, Vivek Singh, Lin Du, Jennifer A. Wilson +7 more

Isolation and structure elucidation of Dm-CVNH, a new cyanovirin-N homolog with activity against SARS-CoV-2 and HIV-1

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108319

N/A

0DataRank · unranked

0 citations

Lauren R. H. Krumpe, Shilpa R. Shenoy, Jennifer A. Wilson, Tad Guszczynski, Curtis J. Henrich +11 more

ShiftScan: A tool for rapid analysis of high‐throughput differential scanning fluorimetry data and compound prioritization

Protein Science(2025)10.1002/pro.70055

N/A

0DataRank · unranked

0 citations

Shilpa R. Shenoy, Nirmala Sharma, Chris Wolcott, Duncan Donohue, Barry R. O’Keefe +2 more

Antiproliferative cassaine diterpenoid amines from the leaves and twigs of the traditional Thai medicinal plant Erythrophleum teysmannii (Kurz) Craib

Journal of Ethnopharmacology(2025)10.1016/j.jep.2025.120167

N/A

0DataRank · unranked

0 citations

Dongdong Wang, Lin Du, Somsak Ruchirawat, Prasat Kittakoop, Tanja Grkovic +3 more

Utilizing the HiBiT System to Identify CARM1 Degraders for Targeted Cancer Therapy

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01863

N/A

0DataRank · unranked

0 citations

Mingshan Hu, Fabao Liu, Eui-Jun Kim, Tanja Grkovic, Rohitesh Kumar +10 more

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

Environmental Microbiology(2025)10.1111/1462-2920.70112

N/A

0DataRank · unranked

2 citations

Susan Egbert, John L. Sorensen, Barry R. O’Keefe, John A. Beutler, Samantha C. Waterworth

National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library

ACS Chemical Biology(2020)10.1021/acschembio.0c00139

N/A

0DataRank · unranked

81 citations

Rhone K. Akee, Christopher C. Thornburg, Spencer K. Trinh, John R. Britt, Matthew Harris +8 more

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge

The Journal of Infectious Diseases(2020)10.1093/infdis/jiz630

N/A

0DataRank · unranked

60 citations

Jessica R. Spengler, Lauren R. H. Krumpe, Stephen R. Welch, Anasuya Chattopadhyay, Jessica R. Harmon +10 more

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

Journal of the American Chemical Society(2020)10.1021/jacs.0c10418

N/A

0DataRank · unranked

20 citations

Brice A. P. Wilson, Christophe Marchand, Suthananda N. Sunassee, Alun Bermingham, Wenjie Wang +9 more

Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris

Journal of Natural Products(2020)10.1021/acs.jnatprod.9b00896

N/A

0DataRank · unranked

13 citations

April L. Risinger, Cora L. Petersen, Huiyun Liang, Tanja Grkovic, Barry R. O’Keefe +3 more

Barry R. O’Keefe

Indexed papers

Top data-sharing exemplar

Papers