Tinghu Zhang

Biochemistry, Genetics and Molecular BiologyComputer ScienceMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 43 papers. Top paper: “Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors”.

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c01548

N/A

1.3DataRank · unranked

47 citations

Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro +16 more

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Cancer Cell(2020)10.1016/j.ccell.2019.12.006

N/A

0.925DataRank · unranked

477 citations

Yao Liu, Ciric To, Tinghu Zhang, Mengyang Fan, Amir Vajdi +39 more

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

Cell(2020)10.1016/j.cell.2020.02.012

N/A

0.908DataRank · unranked

424 citations

Mark P. Jedrychowski, Devin K. Schweppe, Edward L. Huttlin, Qing Yu, David E. Heppner +15 more

Rewiring cancer drivers to activate apoptosis

Nature(2023)10.1038/s41586-023-06348-2

N/A

0.768DataRank · unranked

166 citations

A. Krokhotin, Wenzhi Ji, Xiaofan Liu, Chiung-Ying Chang, Samuel H. Kim +10 more

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Cell Reports(2021)10.1016/j.celrep.2020.108532

N/A

0.716DataRank · unranked

117 citations

Geoffrey M. Matthews, Sara Gandolfi, Ricardo De Matos Simoes, Dennis L. Buckley, Joseline Raja +34 more

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Cancer Research(2023)10.1158/0008-5472.can-23-2729

N/A

0.704DataRank · unranked

108 citations

Hsin‐Yi Huang, Ziyan Lin, Michela Ranieri, Shuai Li, Soumyadip Sahu +21 more

Development of CDK2 and CDK5 Dual Degrader TMX‐2172

Angewandte Chemie International Edition(2020)10.1002/anie.202004087

N/A

0.659DataRank · unranked

80 citations

Jie Jiang, Zhixiang He, Nicholas Kwiatkowski, Katherine A. Donovan, Caitlin E. Mills +7 more

Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2

Angewandte Chemie International Edition(2021)10.1002/anie.202101328

N/A

0.612DataRank · unranked

58 citations

Jie Jiang, Qibiao Wu, Nathaniel J. Henning, Katherine A. Donovan, Hong Yue +7 more

Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor

Nature Chemical Biology(2023)10.1038/s41589-023-01273-x

N/A

0.584DataRank · unranked

48 citations

Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk‐Soo Seo, Ekaterina V. Vinogradova +15 more

PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors

Analytical Chemistry(2021)10.1021/acs.analchem.1c02349

N/A

0.520DataRank · unranked

31 citations

Scott B. Ficarro, William M. Alexander, Laura E. Fleming, Guillaume Adelmant, Tinghu Zhang +10 more

Selective degradation-inducing probes for studying cereblon (CRBN) biology

RSC Medicinal Chemistry(2021)10.1039/d0md00382d

N/A

0.500DataRank · unranked

27 citations

Guangyan Du, Jonathan W. Bushman, Zhixiang He, Tinghu Zhang, Eric S. Fischer +2 more

Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c01834

N/A

0.500DataRank · unranked

27 citations

Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li +17 more

Targeting transcription in heart failure via CDK7/12/13 inhibition

Nature Communications(2022)10.1038/s41467-022-31541-8

N/A

0.425DataRank · unranked

16 citations

Qiming Duan, Daniel S. Day, Xin Luo, Sarah McMahon, Yu Huang +13 more

A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2110557119

N/A

0.406DataRank · unranked

14 citations

Chun‐Hao Huang, Francisco J. Sánchez‐Rivera, Margaret C. Kennedy, Darjus F. Tschaharganeh, John P. Morris +15 more

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Advanced Science(2024)10.1002/advs.202405829

N/A

0.373DataRank · unranked

11 citations

Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang +13 more

Development of potent and selective degraders of PI5P4Kγ

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.115027

N/A

0.373DataRank · unranked

11 citations

Eric S. Wang, Theresa Manz, Jie Jiang, Katherine A. Donovan, Xianmixinuer Abulaiti +5 more

Rewiring Cancer Drivers to Activate Apoptosis

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.04.517548

N/A

0.330DataRank · unranked

8 citations

A. Krokhotin, Wenzhi Ji, Xiaofan Liu, Chiung-Ying Chang, Samuel H. Kim +7 more

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex

Cancer Discovery(2025)10.1158/2159-8290.cd-25-0271

N/A

0.269DataRank · unranked

5 citations

Wenzhi Ji, Brendan G. Dwyer, Joey Lu, Jing Bian, Gianna M. Colombo +23 more

Development of CDK2 and CDK5 Dual Degrader TMX‐2172

Angewandte Chemie(2020)10.1002/ange.202004087

N/A

0.269DataRank · unranked

5 citations

Jie Jiang, Zhixiang He, Nicholas Kwiatkowski, Katherine A. Donovan, Caitlin E. Mills +7 more

Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)

Angewandte Chemie International Edition(2023)10.1002/anie.202308292

N/A

0.269DataRank · unranked

5 citations

Woong Sub Byun, Wenchao Lu, Xijun Zhu, Katherine A. Donovan, Brendan G. Dwyer +8 more

ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c01891

N/A

0.241DataRank · unranked

4 citations

Wenchao Lu, Tyler S. Beyett, Scott B. Ficarro, Jie Jiang, Jason Tse +8 more

Borrowing Transcriptional Kinases to Activate Apoptosis

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.23.563687

N/A

0.241DataRank · unranked

4 citations

Sai Gourisankar, Basel A. Karim, Sabin A. Nettles, Haopeng Yang, Brendan G. Dwyer +10 more

An AKR1C3-activated kinase inhibitor prodrug

RSC Chemical Biology(2025)10.1039/d5cb00219b

N/A

0DataRank · unranked

0 citations

Michael Martinez, Woong Sub Byun, Anuradha Thathireddy, Tian Qiu, Yaning Wang +9 more

Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

Cell chemical biology(2020)10.1016/j.chembiol.2020.02.003

N/A

0DataRank · unranked

56 citations

Hyeseok Shim, Tinghu Zhang, Fleur M. Ferguson, Mark R. Lundquist, Christopher M. Browne +16 more

Structure and Characterization of a Covalent Inhibitor of Src Kinase

Frontiers in Molecular Biosciences(2020)10.3389/fmolb.2020.00081

N/A

0DataRank · unranked

27 citations

Guangyan Du, Nathaniel J. Henning, Suman Rao, Asim K. Bera, Tinghu Zhang +3 more

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01832

N/A

0DataRank · unranked

57 citations

Wenchao Lu, Katherine A. Donovan, Jialin Sun, Noah M. Krupnick, Radosław P. Nowak +7 more

Targeting oncoproteins with a positive selection assay for protein degraders

Science Advances(2021)10.1126/sciadv.abd6263

N/A

0DataRank · unranked

47 citations

Leslie Duplaquet, Benjamin L. Lampson, Adam C. Wang, Amin H. Sabet, Mette Ishoey +21 more

Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development

ACS Medicinal Chemistry Letters(2021)10.1021/acsmedchemlett.1c00285

N/A

0DataRank · unranked

15 citations

Jie Jiang, Scott B. Ficarro, Hyuk‐Soo Seo, Jae Hyun Bae, Katherine A. Donovan +6 more

Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2

Angewandte Chemie(2021)10.1002/ange.202101328

N/A

0DataRank · unranked

6 citations

Jie Jiang, Qibiao Wu, Nathaniel J. Henning, Katherine A. Donovan, Hong Yue +7 more

Development of PRPK Directed Phthalimides

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.30.469594

N/A

0DataRank · unranked

0 citations

Takashi Mizutani, Teru Hideshima, Nicholas E. Vangos, Tinghu Zhang, Kenneth C. Anderson +3 more

Exploring the target scope of KEAP1 E3 ligase-based PROTACs

Cell chemical biology(2022)10.1016/j.chembiol.2022.08.003

N/A

0DataRank · unranked

90 citations

Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak +14 more

Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

Frontiers in Oncology(2022)10.3389/fonc.2021.773186

N/A

0DataRank · unranked

24 citations

Marina P. Volegova, Nicole Nasholm, Sanjukta Das, Nicholas Kwiatkowski, Brian J. Abraham +6 more

Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c01864

N/A

0DataRank · unranked

42 citations

Baishan Jiang, Hellen Kim, Matthew J. Berberich, Jianwei Che, Katherine A. Donovan +13 more

Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)

Angewandte Chemie(2023)10.1002/ange.202308292

N/A

0DataRank · unranked

0 citations

Woong Sub Byun, Wenchao Lu, Xijun Zhu, Katherine A. Donovan, Brendan G. Dwyer +8 more

Relocalizing transcriptional kinases to activate apoptosis

Science(2024)10.1126/science.adl5361

N/A

0DataRank · unranked

58 citations

Sai Gourisankar, Basel A. Karim, Sabin A. Nettles, Haopeng Yang, Brendan G. Dwyer +10 more

Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism

Nature Communications(2024)10.1038/s41467-024-49161-9

N/A

0DataRank · unranked

24 citations

Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P. Golden +7 more

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

ACS Central Science(2024)10.1021/acscentsci.3c01245

N/A

0DataRank · unranked

15 citations

Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares +9 more

Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7)

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116613

N/A

0DataRank · unranked

7 citations

Guangyan Du, Jie Jiang, Wenchao Lu, Caitlin E. Mills, Linjie Yuan +10 more

Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis

Science Translational Medicine(2024)10.1126/scitranslmed.adq5091

N/A

0DataRank · unranked

7 citations

Gayathri Shibu, Baila A. Sokolsky, Tamar Nicole Soussana, Logan Fisher, Dinesh K. Deochand +12 more

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.01.596987

N/A

0DataRank · unranked

6 citations

Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang +13 more

Activating p53 Y220C with a Mutant-Specific Small Molecule

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.23.619961

N/A

0DataRank · unranked

4 citations

Woong Sub Byun, Dominika Ewa Pieńkowska, Kha The Nguyen, Jan Gerhartz, Qixiang Geng +11 more

Design and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.03.686423

N/A

0DataRank · unranked

0 citations

Yeuan Ting Lee, Brendan G. Dwyer, Yi Jer Tan, Ting Chen, Belén Romero +8 more

Partitioning of cancer therapeutics in nuclear condensates

Science(2020)10.1126/science.aaz4427

N/A

0DataRank · unranked

528 citations

Ann Boija, Lena K. Afeyan, Susana Wilson Hawken, Mengyang Fan, Alessandra Dall’Agnese +27 more