Rachel F. Tyndale

ORCID: 0000-0003-1297-2053

Also affiliated with University of Toronto, Canada Research Chairs, Tyndale University, Mental Health Research Canada

MedicineBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsNeuroscienceChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 52 papers. Top paper: “PharmVar GeneFocus: CYP2B6”.

PharmVar GeneFocus: CYP2B6

Clinical Pharmacology & Therapeutics(2021)10.1002/cpt.2166

N/A

7.1DataRank · unranked

239 citations

Ahmed El‐Boraie, Li Gong, Andrew A. Somogyi, Volker M. Lauschke, Collet Dandara +7 more

Transferability of Ancestry‐Specific and Cross‐Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations

Clinical Pharmacology & Therapeutics(2020)10.1002/cpt.2135

N/A

0.699DataRank · unranked

25 citations

Meghan J. Chenoweth, Jennie G. Pouget, Neal L. Benowitz, Koya Fukunaga, Taisei Mushiroda +7 more

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy

Clinical Pharmacology & Therapeutics(2024)10.1002/cpt.3338

N/A

0.620DataRank · unranked

22 citations

Seenae Eum, Zeruesenay Desta, Rachel F. Tyndale, Andrea Gaedigk, Richard C. Crist +12 more

Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking

Pharmacology Biochemistry and Behavior(2016)10.1016/j.pbb.2016.05.002

N/A

0.617DataRank · unranked

60 citations

Noah R. Gubner, Rachel F. Tyndale, Larry W. Hawk, Caryn Lerman, Tony P. George +4 more

Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB

Neuropsychopharmacology(2020)10.1038/s41386-020-0606-2

N/A

0.593DataRank · unranked

51 citations

Belinda Williams, Bernard Le Foll, Esmaeil Mansouri, Richard P. Bazinet, Lin Lin +12 more

Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations

Preventive Medicine(2020)10.1016/j.ypmed.2020.106189

N/A

0.526DataRank · unranked

13 citations

Michael DeSarno, Danielle R. Davis, Tyler Nighbor, Joanna M Streck, Shana Adise +14 more

PharmVar GeneFocus: CYP2A6

Clinical Pharmacology & Therapeutics(2024)10.1002/cpt.3387

N/A

0.505DataRank · unranked

16 citations

Meghan J. Chenoweth, David Twesigomwe, Giada Scantamburlo, Michelle Whirl‐Carrillo, Katrin Sangkuhl +5 more

Sex Differences in the Association of Cigarette Craving With Insula Structure

The International Journal of Neuropsychopharmacology(2021)10.1093/ijnp/pyab015

N/A

0.483DataRank · unranked

24 citations

Jean‐Baptiste Pochon, Dara G. Ghahremani, Andy C. Dean, Paul Faulkner, Nicole Petersen +7 more

Functional connectivity of the anterior insula during withdrawal from cigarette smoking

Neuropsychopharmacology(2021)10.1038/s41386-021-01036-z

N/A

0.470DataRank · unranked

22 citations

Jean-Baptiste Pochon, Maylen Perez Diaz, Rachel F. Tyndale, Andy C. Dean, Edythe D. London +1 more

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans

Scientific Reports(2021)10.1038/s41598-021-98883-z

N/A

0.457DataRank · unranked

20 citations

Lisa Sanderson Cox, Nikki L. Nollen, Jasjit S. Ahluwalia, Neal L. Benowitz, Caryn Lerman +3 more

Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [11C]CURB in Heavy-Drinking Youth

Biological Psychiatry(2022)10.1016/j.biopsych.2022.11.022

N/A

0.434DataRank · unranked

17 citations

Christian S. Hendershot, Jennifer F. Buckman, Samantha Jagasar, Matthew D. McPhee, Neel Muzumdar +8 more

Effects of open-label transdermal nicotine antidepressant augmentation on affective symptoms and executive function in late-life depression

Journal of Affective Disorders(2024)10.1016/j.jad.2024.07.025

N/A

0.401DataRank · unranked

8 citations

Jennifer N. Vega, Sarah M. Szymkowicz, Paul Newhouse, Rachel F. Tyndale, Damian Elson +7 more

Influence of CYP2A6 Genetic Variation, Nicotine Dependence Severity, and Treatment on Smoking Cessation Success

Nicotine & Tobacco Research(2023)10.1093/ntr/ntac268

N/A

0.365DataRank · unranked

8 citations

Caryn Lerman, Jo Knight, Rachel F. Tyndale, Meghan J. Chenoweth

Effect of Extending the Duration of Prequit Treatment With Varenicline on Smoking Abstinence

JAMA Network Open(2022)10.1001/jamanetworkopen.2022.41731

N/A

0.354DataRank · unranked

8 citations

Stephen T. Tiffany, Craig R. Colder, Rebecca L. Ashare, Jennifer M. Wray, Rachel F. Tyndale +3 more

A Genome-Wide Association Study of Nausea Incidence in Varenicline-Treated Cigarette Smokers

Nicotine & Tobacco Research(2021)10.1093/ntr/ntab044

N/A

0.349DataRank · unranked

6 citations

Caryn Lerman, Jo Knight, Rachel F. Tyndale, Meghan J. Chenoweth

Evaluating Treatment Mechanisms of Varenicline: Mediation by Affect and Craving

Nicotine & Tobacco Research(2022)10.1093/ntr/ntac138

N/A

0.340DataRank · unranked

7 citations

Craig R. Colder, Martin C. Mahoney, Gary E. Swan, Paul M. Cinciripini, Robert A. Schnoll +4 more

Relationships Between the Nicotine Metabolite Ratio and Laboratory Assessments of Smoking Reinforcement and Craving Among Adults in a Smoking Cessation Trial

Nicotine & Tobacco Research(2023)10.1093/ntr/ntad232

N/A

0.310DataRank · unranked

4 citations

Martin C. Mahoney, Stephen T. Tiffany, Craig R. Colder, Rachel F. Tyndale, Larry W Hawk +1 more

Pharmacogenetics of Biochemically Verified Abstinence in an Opioid Agonist Therapy Randomized Clinical Trial of Methadone and Buprenorphine/Naloxone

Clinical Pharmacology & Therapeutics(2023)10.1002/cpt.3112

N/A

0.292DataRank · unranked

6 citations

Meghan J. Chenoweth, Didier Jutras‐Aswad, Keith Ahamad, M. Eugenia Socías, Bernard Le Foll +2 more

Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats

Brain Research Bulletin(2020)10.1016/j.brainresbull.2020.09.001

N/A

0.292DataRank · unranked

6 citations

Ahmed A. El-Sherbeni, Janielle Richards, Rachel F. Tyndale, Douglas M. McMillan

Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion‐aided smoking cessation in African Americans? A moderated mediation analysis

Addiction(2021)10.1111/add.15742

N/A

0.254DataRank · unranked

4 citations

Annie R. Peng, Andy Z. X. Zhu, Lisa Sanderson Cox, Nicole L. Nollen, Jasjit S. Ahluwalia +5 more

Identification of Sociodemographic, Clinical, and Genetic Factors to Aid Alaska Native and American Indian People to Successfully Quit Smoking

Nicotine & Tobacco Research(2023)10.1093/ntr/ntad133

N/A

0.228DataRank · unranked

3 citations

Krista R. Schaefer, Carolyn Noonan, Susan Brown Trinidad, Clemma Muller, Katrina G. Claw +7 more

Comparing the Rate of Nicotine Metabolism Among Smokers With Current or Past Major Depressive Disorder

American Journal on Addictions(2021)10.1111/ajad.13155

N/A

0.208DataRank · unranked

3 citations

E. Paul Wileyto, Anna‐Marika Bauer, Erica Fox, Frank T. Leone, Caryn Lerman +9 more

Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension

European Journal of Human Genetics(2023)10.1038/s41431-023-01518-2

N/A

0.165DataRank · unranked

2 citations

Jennie G. Pouget, Jo Knight, Meghan J. Chenoweth, Rachel F. Tyndale, Alec W. R. Langlois

Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome‐Wide Investigation of Abnormal Dreams on Varenicline

Clinical Pharmacology & Therapeutics(2024)10.1002/cpt.3210

N/A

0.136DataRank · unranked

1 citations

Yong‐Jae Kim, Nikki L. Nollen, Larry W. Hawk, Martin C. Mahoney, Caryn Lerman +3 more

Sex dependent genetic architecture of biochemically verified tobacco use

Psychiatry Research(2025)10.1016/j.psychres.2025.116465

N/A

0.104DataRank · unranked

1 citations

Caryn Lerman, Jo Knight, Rachel F. Tyndale, Meghan J. Chenoweth

Daily Cigarette Abstinence and Smoking Rate With Varenicline: Relationships With Treatment, Craving, and Affect During the First Week of the Quit Attempt

Nicotine & Tobacco Research(2025)10.1093/ntr/ntaf095

N/A

0.104DataRank · unranked

1 citations

Jennifer Betts, Ashley N Dowd, Martin C. Mahoney, Paul M. Cinciripini, Robert A. Schnoll +4 more

Sex, estrous cycle, and hormone regulation of CYP2D in the brain alters oxycodone metabolism and analgesia

Biochemical Pharmacology(2022)10.1016/j.bcp.2022.114949

N/A

0DataRank · unranked

16 citations

Janielle Richards, Ahmed A. El-Sherbeni, Sharon Miksys, Rachel F. Tyndale, Nicole Arguelles

CYP2D in the brain impacts oral hydrocodone analgesia in vivo

Neuropharmacology(2022)10.1016/j.neuropharm.2022.109291

N/A

0DataRank · unranked

3 citations

Sharon Miksys, Maria Novalen, Rachel F. Tyndale, Janielle Richards

Examining the role of mitochondrial genetic variation in nicotine dependence

Psychiatry Research(2022)10.1016/j.psychres.2022.114452

N/A

0DataRank · unranked

0 citations

Meghan J. Chenoweth, Paulo Saquilayan, Rachel F. Tyndale, Caryn Lerman, James L. Kennedy +3 more

Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder—Preliminary Findings

Brain Sciences(2023)10.3390/brainsci13101375

N/A

0DataRank · unranked

23 citations

Erin Gaudette, Richard P. Bazinet, Lin Lin, Rachel F. Tyndale, Esmaeil Mansouri +7 more

CYP2A6associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian Randomization study

Human Molecular Genetics(2023)10.1093/hmg/ddad172

N/A

0DataRank · unranked

9 citations

Meghan J. Chenoweth, Jennie G. Pouget, Ahmed El‐Boraie, Alaa Alsaafin, Caryn Lerman +3 more

Stability of Varenicline Concentration in Saliva Over 21 Days at Three Storage Temperatures

Nicotine & Tobacco Research(2021)10.1093/ntr/ntab173

N/A

0DataRank · unranked

6 citations

Meghan J. Chenoweth, Bin Zhao, Larry W Hawk, Rachel F. Tyndale, Maria Novalen

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

Clinical and Translational Science(2021)10.1111/cts.13135

N/A

0DataRank · unranked

10 citations

Julie‐Anne Tanner, Andy Z. X. Zhu, Katrina G. Claw, Bhagwat Prasad, Erin G. Schuetz +8 more

Behavioral and Pharmacokinetic Assessment of Nicotine e-Cigarette Inhalation in Female Rats

Nicotine & Tobacco Research(2023)10.1093/ntr/ntad240

N/A

0DataRank · unranked

5 citations

Abrianna Mihalkovic, Brittany Richardson, Samantha Penman, Maria Novalen, Nikki Hammond +5 more

Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals

Journal of Psychiatry and Neuroscience(2021)10.1503/jpn.200010

N/A

0DataRank · unranked

21 citations

Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella +7 more

Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke

Clinical and Translational Science(2021)10.1111/cts.13115

N/A

0DataRank · unranked

7 citations

Jaedon P. Avey, Michael R. Todd, Julie A. Beans, Denise A. Dillard, Laura M. Shireman +6 more

Impact of CYP2A6 Activity on Nicotine Reinforcement and Cue-Reactivity in Daily Smokers

Nicotine & Tobacco Research(2021)10.1093/ntr/ntab064

N/A

0DataRank · unranked

14 citations

Meghan J. Chenoweth, Ahmed El‐Boraie, Haidy Giratallah, William J. Kowalczyk, Stephen J. Heishman +3 more

Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies

Drug and Alcohol Dependence(2021)10.1016/j.drugalcdep.2021.108708

N/A

0DataRank · unranked

16 citations

Meghan J. Chenoweth, Newton Addo, Jasjit S. Ahluwalia, Lisa Sanderson Cox, Caryn Lerman +4 more

Genetics of Smoking Behaviors in American Indians

Cancer Epidemiology Biomarkers & Prevention(2020)10.1158/1055-9965.epi-20-0026

N/A

0DataRank · unranked

3 citations

Dedra Buchwald, Barbara V. Howard, Patricia Nez Henderson, Yafang Li, Rachel F. Tyndale +3 more

Imaging Brain Fatty Acid Amide Hydrolase in Untreated Patients With Psychosis

Biological Psychiatry(2020)10.1016/j.biopsych.2020.03.003

N/A

0DataRank · unranked

28 citations

Maya R. Jacobson, Nittha Lalang, Isabelle Boileau, Rachel F. Tyndale, Michael Kiang +6 more

Human CYP2D6 varies across the estrous cycle in brains of transgenic mice altering drug response

Progress in Neuro-Psychopharmacology and Biological Psychiatry(2024)10.1016/j.pnpbp.2024.111108

N/A

0DataRank · unranked

2 citations

Claire McDonald, Fariba Baghai Wadji, Frank J. Gonzalez, Rachel F. Tyndale, Sharon Miksys

Addressing the instability issue of dopamine during microdialysis: the determination of dopamine, serotonin, methamphetamine and its metabolites in rat brain

Journal of Chromatography A(2020)10.1016/j.chroma.2020.461403

N/A

0DataRank · unranked

34 citations

Marlaina R. Stocco, Fariba Baghai Wadji, Rachel F. Tyndale, Ahmed A. El-Sherbeni

Implementing a Metabolism-Informed Approach for Smoking Cessation in an Alaska Tribal Health System: Study Protocol for a Single-Arm Implementation Pilot Trial

Research Square(2024)10.21203/rs.3.rs-3874126/v1

N/A

0DataRank · unranked

0 citations

Brianna Tranby, Aliassa L. Shane, Todd Takeno, Kelly Chadwick, Pamela S. Sinicrope +6 more

Implementing a Metabolism-informed approach for smoking cessation in an Alaska Tribal health system: study protocol for a single-arm implementation pilot trial

Archives of Public Health(2024)10.1186/s13690-024-01365-7

N/A

0DataRank · unranked

0 citations

Brianna Tranby, Aliassa L. Shane, Todd Takeno, Kelly Chadwick, Pamela S. Sinicrope +6 more

Age (juvenile to aged) and sex effects on in vitro CYP2A6 enzyme activity in African green monkeys using nicotine and coumarin

Drug Metabolism and Disposition(2026)10.1016/j.dmd.2026.100335

N/A

0DataRank · unranked

0 citations

Rachel F. Tyndale, Weilong Gu

Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice

Molecular Neurobiology(2020)10.1007/s12035-020-01896-4

N/A

0DataRank · unranked

32 citations

Marlaina R. Stocco, Sharon Miksys, Frank J. Gonzalez, Rachel F. Tyndale, Edgor Cole Tolledo

Extending Investigations of miR‐126‐5p on the Regulation of CYP2A6, the Major Nicotine‐Inactivating Enzyme

Pharmacology Research & Perspectives(2025)10.1002/prp2.70149

N/A

0DataRank · unranked

1 citations

Alec W. R. Langlois, Haidy Giratallah, Katrina G. Claw, Bhagwat Prasad, Kenneth E. Thummel +2 more

A multi-site study examining the tobacco withdrawal trajectory in people with tobacco and cannabis co-use

Drug and Alcohol Dependence(2025)10.1016/j.drugalcdep.2025.112778

N/A

0DataRank · unranked

0 citations

Caryn Lerman, Robert A. Schnoll, Rachel F. Tyndale, Tony P. George, Rachel A. Rabin

Evaluating the reinforcing properties of oxycodone and oxymorphone using intravenous drug self-administration in male rats

Neuropharmacology(2025)10.1016/j.neuropharm.2025.110698

N/A

0DataRank · unranked

0 citations

Douglas Funk, Paul Fletcher, Sharon Miksys, Rachel F. Tyndale, Mina Rashvand

The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers

Brain and Behavior(2020)10.1002/brb3.1982

N/A

0DataRank · unranked

10 citations

William J. Kowalczyk, Marie Gendy, Richard Taylor, Rachel F. Tyndale, Bernard Le Foll +2 more

Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice

Molecular Neurobiology(2020)10.1007/s12035-020-02050-w

N/A

0DataRank · unranked

11 citations

Edgor Cole Tolledo, Fariba Baghai Wadji, Frank J. Gonzalez, Sharon Miksys, Rachel F. Tyndale +1 more

Dispositional optimism and optimistic bias: Associations with cessation motivation, confidence, and attitudes.

Health Psychology(2022)10.1037/hea0001184

N/A

0DataRank · unranked

12 citations

William M. P. Klein, Scott S. Lee, Rebecca Selove, Maureen Sanderson, William J. Blot +19 more