Todd D. Gould

Also affiliated with VA Maryland Health Care System

MedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 34 papers. Top paper: “A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression”.

A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression

The International Journal of Neuropsychopharmacology(2020)10.1093/ijnp/pyaa025

N/A

1.6DataRank · unranked

62 citations

Bashkim Kadriu, Todd D. Gould, Panos Zanos, Deanna Greenstein, Jennifer W. Evans +12 more

Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration

Translational Psychiatry(2022)10.1038/s41398-022-01941-x

N/A

0.928DataRank · unranked

32 citations

Panos Zanos, Cristan Farmer, Bashkim Kadriu, Patrick J. Morris, Jacqueline Lovett +10 more

Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies

The Lancet Psychiatry(2023)10.1016/s2215-0366(23)00183-9

N/A

0.557DataRank · unranked

40 citations

Malcolm Matheson, Isabella Demo, Matthew J. Reid, Sharaya Matheson, Claire Twose +6 more

A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801

Neurotoxicology and Teratology(2021)10.1016/j.ntt.2021.106993

N/A

0.505DataRank · unranked

28 citations

Richard Burke, Alok Sharma, Daniel C. Lynch, Leslie E. Lemke-Boutcher, Shiny Mathew +8 more

Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines

ACS Chemical Neuroscience(2022)10.1021/acschemneuro.1c00761

N/A

0.494DataRank · unranked

26 citations

Patrick J. Morris, Kylie M. Konrath, Lace M. Riggs, Natalie R. Hagen, Panos Zanos +6 more

Treatment of depression with ketamine does not change plasma levels of brain-derived neurotrophic factor or vascular endothelial growth factor

Journal of Affective Disorders(2020)10.1016/j.jad.2020.11.011

N/A

0.477DataRank · unranked

23 citations

Dede Greenstein, Bashkim Kadriu, Peixiong Yuan, Lawrence T. Park, Todd D. Gould +2 more

Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

Molecular Psychiatry(2022)10.1038/s41380-022-01609-4

N/A

0.373DataRank · unranked

11 citations

Lace M. Riggs, Tatyana Shekhtman, J. R. Ashworth, Robert Lease, Rediet T. Oshone +15 more

κ-Opioid Receptor Plasma Levels Are Associated With Sex and Diagnosis of Major Depressive Disorder But Not Response to Ketamine

Journal of Clinical Psychopharmacology(2023)10.1097/jcp.0000000000001663

N/A

0.284DataRank · unranked

4 citations

Gustavo C. Medeiros, Dede Greenstein, Peixiong Yuan, Jenessa N. Johnston, Lawrence T. Park +4 more

Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient

Neuropsychopharmacology(2023)10.1038/s41386-023-01675-4

N/A

0.241DataRank · unranked

4 citations

Todd D. Gould, Kyle A. Brown

Estradiol mediates stress-susceptibility in the male brain

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.09.475485

N/A

0.241DataRank · unranked

4 citations

Ta-Chung M. Mou, Liam E. Potter, Xiaoxian An, Panos Zanos, Michael S. Patton +11 more

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions

Neuropharmacology(2024)10.1016/j.neuropharm.2024.110065

N/A

0.208DataRank · unranked

3 citations

Jean‐Philippe Guilloux, Céline Defaix, Indira Mendez‐David, Isabelle Etting, Jean‐Claude Alvarez +11 more

A rare variant in D-amino acid oxidase implicates NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

medRxiv(2021)10.1101/2021.06.02.21258261

N/A

0.165DataRank · unranked

2 citations

Lace M. Riggs, Tatyana Shekhtman, J. R. Ashworth, Robert Lease, Rediet T. Oshone +15 more

Targeting metaplasticity mechanisms to promote sustained antidepressant actions

Molecular Psychiatry(2024)10.1038/s41380-023-02397-1

N/A

0DataRank · unranked

47 citations

Todd D. Gould, Kyle A. Brown

A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)‐Hydroxynorketamine in Healthy Volunteers

Clinical Pharmacology & Therapeutics(2024)10.1002/cpt.3391

N/A

0DataRank · unranked

34 citations

Jeffrey T. Guptill, Michelle Mack, Marni Peterson, Stephen J. Byard, Robert J. Twieg +36 more

Associations between hypothalamic-pituitary-adrenal (HPA) axis hormone levels, major depression features and antidepressant effects of ketamine

Journal of Affective Disorders(2024)10.1016/j.jad.2024.12.036

N/A

0DataRank · unranked

24 citations

Cristan Farmer, Gustavo C. Medeiros, Peixiong Yuan, Jenessa N. Johnston, Bashkim Kadriu +3 more

Entactogen Effects of Ketamine: A Reverse-Translational Study

American Journal of Psychiatry(2024)10.1176/appi.ajp.20230980

N/A

0DataRank · unranked

12 citations

Dede Greenstein, Olivia L. Hutchinson, Carlos A. Zarate, Todd D. Gould, Evan Hess

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.03.587904

N/A

0DataRank · unranked

0 citations

Jean‐Philippe Guilloux, Céline Defaix, Indira Mendez‐David, Isabelle Etting, Jean‐Claude Alvarez +11 more

Pathophysiologic abnormalities in transgenic mice carrying the Alzheimer disease PSEN1 Δ440 mutation

Human Molecular Genetics(2024)10.1093/hmg/ddae139

N/A

0DataRank · unranked

0 citations

Victoria L Collis, Pallavi Sharma, Angelina M Burkett, Shaoteng Wang, Kyle A. Brown +7 more

Synaptic priming: A framework for pharmacotherapy in depression

Neuron(2025)10.1016/j.neuron.2025.09.010

N/A

0DataRank · unranked

6 citations

Musa Iyiola Ajibola, Gustavo C. Medeiros, Todd D. Gould, Kyle A. Brown

Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity

Neuropsychopharmacology(2025)10.1038/s41386-025-02085-4

N/A

0DataRank · unranked

14 citations

Musa Iyiola Ajibola, Todd D. Gould, Kyle A. Brown

Bioactive ketamine metabolite exerts in vivo neuroplastogenic effects to improve hippocampal function in a treatment-resistant depression model

Cell Reports(2025)10.1016/j.celrep.2025.115743

N/A

0DataRank · unranked

2 citations

Sage Aronson, Ta-Chung M. Mou, Edna F. R. Pereira, Scott M. Thompson, Todd D. Gould +1 more

Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression

Neuropsychopharmacology(2020)10.1038/s41386-020-0663-6

N/A

0DataRank · unranked

83 citations

Jessica R. Gilbert, Ruin Moaddel, Jomy George, Lilian Adeojo, Jacqueline Lovett +7 more

Intermittent Ketamine and Neuromodulation Treatment Evoke Synergistic Antidepressant-Relevant Action

Biological Psychiatry(2025)10.1016/j.biopsych.2025.10.009

N/A

0DataRank · unranked

0 citations

Todd D. Gould, Kyle A. Brown

Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma

Pharmacology Biochemistry and Behavior(2020)10.1016/j.pbb.2020.172973

N/A

0DataRank · unranked

16 citations

Jenica D. Tapocik, Cheryl L. Mayo, Panos Zanos, Todd D. Gould, Gregory I. Elmer

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/wfvq-kk18

N/A

0DataRank · unranked

0 citations

Peixiong Yuan, Yuhong Fang, Cheryl L. Mayo, Xi‐Ping Huang, Todd D. Gould +15 more

Mechanisms of ketamine and its metabolites as antidepressants

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114892

N/A

0DataRank · unranked

167 citations

Lace M. Riggs, Michael Michaelides, Todd D. Gould, Evan Hess

Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

Pharmacological Reviews(2021)10.1124/pharmrev.120.000149

N/A

0DataRank · unranked

94 citations

Panos Zanos, Lace M. Riggs, Polymnia Georgiou, Sarah M. Clark, Patrick J. Morris +6 more

Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit–Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice

Biological Psychiatry(2021)10.1016/j.biopsych.2021.11.024

N/A

0DataRank · unranked

29 citations

Panos Zanos, Polymnia Georgiou, Todd D. Gould, Uwe Rudolph, Scott M. Thompson +1 more

Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor

Nature Neuroscience(2022)10.1038/s41593-022-01146-x

N/A

0DataRank · unranked

136 citations

Panos Zanos, Ta-Chung M. Mou, Xiaoxian An, Danielle M. Gerhard, Dilyan I. Dryanovski +17 more

Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search

Molecular Psychiatry(2022)10.1038/s41380-022-01673-w

N/A

0DataRank · unranked

45 citations

Juan L. Gomez, Meghan L. Carlton, Sherry Lam, Marta Sánchez‐Soto, Patrick J. Morris +9 more

Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters

Neuropharmacology(2022)10.1016/j.neuropharm.2022.109403

N/A

0DataRank · unranked

9 citations

Panos Zanos, Chris F. Powels, Connor J. Fix, Michael Michaelides, Edna F. R. Pereira +3 more

Experimenter sex modulates mouse biobehavioural and pharmacological responses

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.09.475572

N/A

0DataRank · unranked

2 citations

Panos Zanos, Ta-Chung M. Mou, Xiaoxian An, Danielle M. Gerhard, Dilyan I. Dryanovski +17 more

NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine

Journal of Neuroscience(2023)10.1523/jneurosci.1316-22.2022

N/A

0DataRank · unranked

109 citations

Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate, Scott M. Thompson +2 more

Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion

iScience(2023)10.1016/j.isci.2023.108527

N/A

0DataRank · unranked

11 citations

Cristan Farmer, Mani Yavi, Bashkim Kadriu, Min Zhu, JINSHUI FAN +13 more