James G. Christensen

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 20 papers. Top paper: “Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer”.

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Cancer Discovery(2024)10.1158/2159-8290.cd-24-0177

N/A

0.828DataRank · unranked

248 citations

Megan T. Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Brendan D. Parent +50 more

Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Cancer Discovery(2022)10.1158/2159-8290.cd-22-0405

N/A

0.744DataRank · unranked

142 citations

Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Esther Kaplun +29 more

Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma

Cancer Discovery(2023)10.1158/2159-8290.cd-23-0289

N/A

0.641DataRank · unranked

71 citations

Xueqian Zhuang, Chun‐Hao Pan, Yan Yan, Rohit Thummalapalli, Jill Hallin +12 more

Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c02140

N/A

0.330DataRank · unranked

8 citations

Dan Chen, James G. Christensen, René Coulombe, James Féthière, Robin J. Gunn +16 more

Molecular characterization of acquired resistance to KRAS G12C inhibition in gastrointestinal cancers

Research Square(2022)10.21203/rs.3.rs-1236956/v1

N/A

0.241DataRank · unranked

2 citations

Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco +23 more

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.29.560194

N/A

0.165DataRank · unranked

2 citations

Xueqian Zhuang, Chun‐Hao Pan, Yan Yan, Rohit Thummalapalli, Jill Hallin +12 more

Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits

RSC Medicinal Chemistry(2022)10.1039/d2md00163b

N/A

0DataRank · unranked

13 citations

Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G. Christensen, Robin J. Gunn +8 more

Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors

Bioorganic & Medicinal Chemistry(2022)10.1016/j.bmc.2022.116947

N/A

0DataRank · unranked

15 citations

Ruth Aranda, James G. Christensen, Lars D. Engstrom, Robin J. Gunn, Anthony Ivetac +10 more

A Non-covalent KRASG12D Allele Specific Inhibitor Demonstrates Potent Inhibition of KRAS-dependent Signaling and Regression of KRASG12D-mutant Tumors

Research Square(2022)10.21203/rs.3.rs-1261963/v1

N/A

0DataRank · unranked

1 citations

Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis +25 more

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Cancer Research(2023)10.1158/0008-5472.can-23-2729

N/A

0DataRank · unranked

106 citations

Hsin‐Yi Huang, Ziyan Lin, Michela Ranieri, Shuai Li, Soumyadip Sahu +21 more

Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-23-0795

N/A

0DataRank · unranked

23 citations

Grace A. Heavey, Yanan Kuang, Emily Durlacher, Thian Kheoh, Richard C. Chao +10 more

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

Molecular Cancer Therapeutics(2024)10.1158/1535-7163.mct-23-0870

N/A

0DataRank · unranked

33 citations

Larry Yan, Fadia Qiryaqos, Lars D. Engstrom, Jade Laguer, Andrew Calinisan +29 more

Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c00078

N/A

0DataRank · unranked

21 citations

Stephen J. Harwood, Ruth Aranda, Athenea N. Aloiau, Briana M. Bobek, David M. Briere +25 more

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01688

N/A

0DataRank · unranked

716 citations

Shelley Allen, James F. Blake, Vickie Bowcut, David M. Briere, Andrew Calinisan +23 more

Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial

Clinical Cancer Research(2025)10.1158/1078-0432.ccr-24-2310

N/A

0DataRank · unranked

21 citations

Alvaro G. Paula, David Molkentine, Laura D. Hover, Monique B. Nilsson, Natalie I. Vokes +17 more

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

Cancer Discovery(2021)10.1158/2159-8290.cd-21-0369

N/A

0DataRank · unranked

103 citations

Shuai Li, Alireza Khodadadi‐Jamayran, Jayu Jen, Han Han, Kayla Guidry +13 more

Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.21.436338

N/A

0DataRank · unranked

15 citations

Shuai Li, Alireza Khodadadi‐Jamayran, Jayu Jen, Han Han, Kayla Guidry +11 more

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

Nature Medicine(2022)10.1038/s41591-022-02007-7

N/A

0DataRank · unranked

519 citations

Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom +25 more

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.1c01900

N/A

0DataRank · unranked

152 citations

Ruth Aranda, Thomas P. Bobinski, David M. Briere, Aaron C. Burns, James G. Christensen +18 more

Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00741

N/A

0DataRank · unranked

95 citations

Jacob R. Haling, Shilpi Khare, Vickie Bowcut, David M. Briere, Aaron C. Burns +21 more