Huanchen Wang

National Institute of Environmental Health Sciences

Biochemistry, Genetics and Molecular BiologyChemistryMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 36 papers. Top paper: “Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP 8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode”.

Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP 8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode

Chemical Science(2020)10.1039/d0sc02144j

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0.505DataRank · unranked

9 citations

Nikolaus Jork, Tamara Bittner, Huanchen Wang, Henning J. Jessen, Stephen B. Shears +1 more

KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1

Molecular Cell(2025)10.1016/j.molcel.2025.08.003

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0.391DataRank · unranked

12 citations

Zhongjian Bai, Ciara Wallis, Huanchen Wang, Yaoyao Han, Ruitao Jin +9 more

Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108274

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0.217DataRank · unranked

3 citations

Huanchen Wang, Haibo Zhang, Isabel Prucker, Lalith Perera, Ekaterina I. Goncharova +8 more

Structural insights into the development of inhibitors for inositol phosphate kinases

FEBS Letters(2026)10.1002/1873-3468.70280

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0.165DataRank · unranked

2 citations

Huanchen Wang

Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis

UNC Libraries(2020)10.17615/4qfw-xn22

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0DataRank · unranked

2 citations

Huanchen Wang, Xuan Luo, Hengming Ke, Mengchun Ye, Howard Robinson +1 more

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

UNC Libraries(2020)10.17615/v110-8g62

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0DataRank · unranked

1 citations

Gong Chen, Huanchen Wang, Howard Robinson, Jiwen Cai, Yiqian Wan +1 more

Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E

Figshare(2020)10.17615/yvka-hg40

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0DataRank · unranked

1 citations

Huanchen Wang, Sarah R Hengel, Hengming Ke, Andrew L. Lee, Jun Zhang +3 more

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

UNC Libraries(2020)10.17615/w9qr-pa69

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0DataRank · unranked

1 citations

Yi Chen, Hengming Ke, Miles D. Houslay, Howard Robinson, Jie Geng +3 more

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡

UNC Libraries(2020)10.17615/4qyq-qs72

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0DataRank · unranked

2 citations

Howard Robinson, Hengming Ke, Jiwen Cai, Huanchen Wang, SERENA YANG +1 more

Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase †

UNC Libraries(2020)10.17615/83jp-9g80

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0DataRank · unranked

0 citations

Zheng Huang, Dwight Macdonald, Renée Aspiotis, Howard Robinson, Huanchen Wang +3 more

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

UNC Libraries(2020)10.17615/m52q-g503

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0DataRank · unranked

0 citations

Stephen V. Frye, Kenneth H. Pearce, Michael A. Stashko, Brandi M. Baughman, Yi An +4 more

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

UNC Libraries(2020)10.17615/6hnz-p812

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0DataRank · unranked

0 citations

Coral González‐García, Nuria E. Campillo, Javier Hernández, Jimena Cuenca, Hengming Ke +10 more

Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain

UNC Libraries(2020)10.17615/w3ew-1a89

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0DataRank · unranked

0 citations

Jiwen Cai, Huanchen Wang, Zier Yan, Hengming Ke

Computer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet Design

UNC Libraries(2020)10.17615/c6db-b739

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0DataRank · unranked

0 citations

Xiaozhen Hu, Brian Kuhlman, Hengming Ke, Huanchen Wang

Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors

UNC Libraries(2020)10.17615/absz-fh35

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0DataRank · unranked

0 citations

Thomas Seebeck, Stefan Kunz, Sibylla Martinelli, Huanchen Wang, Gong� Chen +3 more

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis

UNC Libraries(2020)10.17615/1xdg-fm72

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0DataRank · unranked

0 citations

Alexandre Hofer, Xuming Dai, Huanchen Wang, Stephen B. Shears, Henning J. Jessen +2 more

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2020187118

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0DataRank · unranked

34 citations

Juan Liu, Xiaojing Liu, Haibo Zhang, Ji Luo, Huanchen Wang +3 more

New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1

The FASEB Journal(2021)10.1096/fj.202001489r

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0DataRank · unranked

31 citations

Nikolaus Jork, Sarah Hostachy, Dorothea Fiedler, Henning J. Jessen, Stephen B. Shears +2 more

New Structural Insights Reveal an Expanded Reaction Cycle for Inositol Pyrophosphate Hydrolysis by Human DIPP1

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.00386

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0DataRank · unranked

4 citations

Nikolaus Jork, Sarah Hostachy, Dorothea Fiedler, Henning J. Jessen, Stephen B. Shears +2 more

Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT

UNC Libraries(2021)10.17615/7e9p-e025

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0DataRank · unranked

6 citations

Hengming Ke, Yudong Liu, Guiting Lin, Qing Huai, Zhong-Cheng Xin +6 more

The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10

UNC Libraries(2021)10.17615/4pyb-jc31

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0DataRank · unranked

1 citations

Hengming Ke, Huanchen Wang, Howard Robinson

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

UNC Libraries(2021)10.17615/m8g3-vn28

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0DataRank · unranked

0 citations

Laurinda A. Jaffe, Huanchen Wang, Rachael P. Norris, Matthew A. Movsesian, Marina Freudzon +5 more

Structures of the N-Terminal and Middle Domains of E. coli Hsp90 and Conformation Changes upon ADP Binding

UNC Libraries(2021)10.17615/5thf-mm48

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0DataRank · unranked

0 citations

Yudong Liu, Hengming Ke, Qing Huai, Hwa-Young Kim, DAVID O. TOFT +1 more

Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00220

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0DataRank · unranked

32 citations

Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong +7 more

Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs

The FASEB Journal(2022)10.1096/fj.202200393r

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0DataRank · unranked

28 citations

Stephen B. Shears, Huanchen Wang, Guangning Zong

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Nature Communications(2022)10.1038/s41467-022-29673-y

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0DataRank · unranked

24 citations

L. Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter +3 more

IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight

Advances in Biological Regulation(2023)10.1016/j.jbior.2023.101002

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0DataRank · unranked

15 citations

Xingyao Li, Guangning Zong, Huanchen Wang, Stephen B. Shears, Chunfang Gu

Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

Chemistry - A European Journal(2023)10.1002/chem.202302426

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0DataRank · unranked

7 citations

Huanchen Wang, Guangning Zong, Katy Franke, Andrew M. Riley, Peter Schmieder +4 more

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

Cell Reports(2024)10.1016/j.celrep.2024.114316

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0DataRank · unranked

30 citations

Regan B Kirkpatrick, Xiaodong Wang, Charles J. Tucker, Anuj Shukla, Henning J Jessen +4 more

Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus

The EMBO Journal(2024)10.1038/s44318-023-00005-0

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0DataRank · unranked

11 citations

Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B. Shears +2 more

Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure

INDIGO (University of Illinois at Chicago)(2020)10.17615/xprs-ew59

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0DataRank · unranked

4 citations

Hengming Ke, Huanchen Wang, Chimed Jansen, Thomas Seebeck, Iwan J. P. de Esch +6 more

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

UNC Libraries(2020)10.17615/1va5-s052

N/A

0DataRank · unranked

5 citations

Huanchen Wang, Jie Geng, Hengming Ke, Thomas Seebeck, Stefan Kunz +1 more

Structural Rationalization of IPMK Inhibitor Potency

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c02314

N/A

0DataRank · unranked

2 citations

Stephen B. Shears, Raymond D. Blind, Huanchen Wang

Identification of acrylamide-based covalent inhibitors of SARS-CoV-2 (SCoV-2) Nsp15 using high-throughput screening and machine learning

RSC Advances(2025)10.1039/d4ra06955b

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0DataRank · unranked

1 citations

Babak Mosavati, Lydia H. Zhang, Mohammad S. Parsa, Huanchen Wang, Evan Kerek +15 more

Correction: Identification of acrylamide-based covalent inhibitors of SARS-CoV-2 (SCoV-2) Nsp15 using high-throughput screening and machine learning

RSC Advances(2025)10.1039/d5ra90098k

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0DataRank · unranked

0 citations

Babak Mosavati, Lydia H. Zhang, Mohammad S. Parsa, Huanchen Wang, Evan Kerek +15 more

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

UNC Libraries(2020)10.17615/gzjh-6479

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0DataRank · unranked

5 citations

Hengming Ke, Huanchen Wang, Howard Robinson