Daniel J. Siegwart

ORCID: 0000-0003-3823-1931

Also affiliated with The University of Texas Southwestern Medical Center

Biochemistry, Genetics and Molecular BiologyMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 30 papers. Top paper: “Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery”.

Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery

Nature Protocols(2022)10.1038/s41596-022-00755-x

N/A

0.936DataRank · unranked

511 citations

Shuai Liu, Yehui Sun, Xueliang Yu, Sang M. Lee, Qiang Cheng +8 more

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

Proceedings of the National Academy of Sciences(2017)10.1073/pnas.1614035114

N/A

0.935DataRank · unranked

508 citations

Hao Zuo, Hu Xiong, Matthew J. Kolar, Qian Chu, Alan Saghatelian +3 more

In vivo editing of lung stem cells for durable gene correction in mice

Science(2024)10.1126/science.adk9428

N/A

0.769DataRank · unranked

167 citations

Sumanta Chatterjee, Xizhen Lian, Zachary Traylor, Sandhya Ramani Sattiraju, Yufen Xiao +25 more

All‐In‐One Dendrimer‐Based Lipid Nanoparticles Enable Precise HDR‐Mediated Gene Editing In Vivo

Advanced Materials(2021)10.1002/adma.202006619

N/A

0.689DataRank · unranked

98 citations

Qiang Cheng, Tuo Wei, Ester Álvarez‐Benedicto, Lindsay T. Johnson, Sang M. Lee +2 more

Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles

Advanced Materials(2024)10.1002/adma.202313791

N/A

0.641DataRank · unranked

71 citations

Stephen D. Moore, Sumanta Chatterjee, Erick Guerrero, Minjeong Kim, Lukas Farbiak +3 more

A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo

Angewandte Chemie(2020)10.1002/ange.202013927

N/A

0.524DataRank · unranked

32 citations

Qiang Cheng, Xueliang Yu, Shuai Liu, Lindsay T. Johnson, Daniel J. Siegwart +1 more

Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00419

N/A

0.396DataRank · unranked

13 citations

Jamie L. Russell, Yuto Mifune, Ying Wang, Hexin Shi, Eva Marie Y. Moresco +4 more

Endogenous Targeting of Lipid Nanoparticles to Kidney Tumors

ACS Nano(2025)10.1021/acsnano.5c05370

N/A

0.269DataRank · unranked

5 citations

Yun-Chieh Sung, Vanina Toffessi Tcheuyap, Chengcheng Zhang, Ramesh Butti, Arijit Mal +15 more

Spleen SORT LNP Generated in situ CAR T Cells Extend Survival in a Mouse Model of Lymphoreplete B Cell Lymphoma

Angewandte Chemie(2023)10.1002/ange.202310395

N/A

0DataRank · unranked

15 citations

Zeru Tian, Sumanta Chatterjee, Domenico Orlando, Minjung Kim, Erick Guerrero +3 more

Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

Nature Reviews Materials(2023)10.1038/s41578-022-00529-7

N/A

0DataRank · unranked

630 citations

Daniel J. Siegwart, Sean A. Dilliard

Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models

Nature Communications(2023)10.1038/s41467-023-42948-2

N/A

0DataRank · unranked

168 citations

Yehui Sun, Qiang Cheng, Sumanta Chatterjee, Zachary Traylor, Lindsay T. Johnson +9 more

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

Nature Communications(2020)10.1038/s41467-020-17029-3

N/A

0DataRank · unranked

592 citations

Qiang Cheng, Yi-Li Min, Eric N. Olson, Daniel J. Siegwart, Tuo Wei

The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles

Journal of Controlled Release(2023)10.1016/j.jconrel.2023.07.058

N/A

0DataRank · unranked

138 citations

Yehui Sun, Madeline O. Brown, Yun‐Chieh Sung, Sumanta Chatterjee, Lukas Farbiak +6 more

Spleen SORT LNP Generated in situ CAR T Cells Extend Survival in a Mouse Model of Lymphoreplete B Cell Lymphoma

Angewandte Chemie International Edition(2023)10.1002/anie.202310395

N/A

0DataRank · unranked

120 citations

Zeru Tian, Sumanta Chatterjee, Domenico Orlando, Minjung Kim, Erick Guerrero +3 more

In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration

Hepatology(2023)10.1097/hep.0000000000000402

N/A

0DataRank · unranked

5 citations

Qiyu Zeng, Yuemeng Jia, Zixi Wang, Lin Li, Meng-Hsiung Hsieh +11 more

Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells

Nature Nanotechnology(2024)10.1038/s41565-024-01680-8

N/A

0DataRank · unranked

120 citations

Sumanta Chatterjee, Yehui Sun, Sean A. Dilliard, Stephen D. Moore, Yufen Xiao +17 more

Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing

Journal of the American Chemical Society(2024)10.1021/jacs.4c13154

N/A

0DataRank · unranked

11 citations

Yangyang Yang, Xizhen Lian, Fangyu Zhang, Chao Hu, Jet Tsien +15 more

Nucleic Acid Therapy for the Skin

Journal of Investigative Dermatology(2024)10.1016/j.jid.2024.07.029

N/A

0DataRank · unranked

3 citations

Daniel J. Siegwart, Richard C. Wang, Andreas C. Chai

The origin of hepatocellular carcinoma depends on metabolic zonation

Science(2025)10.1126/science.adv7129

N/A

0DataRank · unranked

15 citations

Roger J. Liang, Andrew Chung, Zhijie Li, Boyuan Li, Eric Chen +22 more

Investigating the functional contributions of phospholipids in selective organ targeting lipid nanoparticles

Biomaterials(2025)10.1016/j.biomaterials.2025.123671

N/A

0DataRank · unranked

5 citations

Amogh Vaidya, Julien Santelli, Zeru Tian, Gabriela A Pazzi, Daniel J. Siegwart +1 more

Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle delivery

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.12.653518

N/A

0DataRank · unranked

3 citations

Katelyn Daman, Yehui Sun, Amanda Tutto, Sarah E. Holbrook, Anya T. Joynt +14 more

WITHDRAWN: 3P Engineered protein circuits directly rewire oncogenic Ras signalling to cell death

Annals of Oncology(2025)10.1016/j.annonc.2025.08.440

N/A

0DataRank · unranked

0 citations

Lars C. Moeller, Stephen D. Moore, Shiyu Xia, Kevin Ho, E. Zhang +13 more

Nanotechnology-based mRNA vaccines

Nature Reviews Methods Primers(2023)10.1038/s43586-023-00246-7

N/A

0DataRank · unranked

157 citations

Xiangang Huang, Yonger Xue, Ester Álvarez‐Benedicto, Yesi Shi, Wei Chen +5 more

A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo

Angewandte Chemie International Edition(2020)10.1002/anie.202013927

N/A

0DataRank · unranked

133 citations

Qiang Cheng, Xueliang Yu, Shuai Liu, Lindsay T. Johnson, Daniel J. Siegwart +1 more

Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

ACS Nano(2020)10.1021/acsnano.0c04707

N/A

0DataRank · unranked

124 citations

Qiang Cheng, Lukas Farbiak, Daniel G. Anderson, Robert Langer, Daniel J. Siegwart +1 more

Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo

Journal of Controlled Release(2020)10.1016/j.jconrel.2020.06.030

N/A

0DataRank · unranked

86 citations

Shuai Liu, Tuo Wei, Qiang Cheng, Daniel J. Siegwart, Hu Xiong

Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver

Advanced Healthcare Materials(2020)10.1002/adhm.201901487

N/A

0DataRank · unranked

41 citations

Shuai Liu, Qiang Cheng, Tuo Wei, Sang M. Lee, Di Zhang +2 more

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

Nature Materials(2021)10.1038/s41563-020-00886-0

N/A

0DataRank · unranked

624 citations

Qiang Cheng, Tuo Wei, Xueliang Yu, Lindsay T. Johnson, Lukas Farbiak +2 more

TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity

Cell(2021)10.1016/j.cell.2021.04.047

N/A

0DataRank · unranked

86 citations

Katrina B. Mar, Levent Sari, Ilona K. Gaszek, Qiang Cheng, Bret M. Evers +6 more

Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration

Pharmaceutics(2021)10.3390/pharmaceutics13111914

N/A

0DataRank · unranked

19 citations

Shuai Liu, Qiang Cheng, Sang M. Lee, Tuo Wei, Di Zhang +5 more