Rana Rais

United States Food and Drug Administration

Also affiliated with Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center

Biochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 52 papers. Top paper: “Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells”.

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

Journal of Clinical Investigation(2020)10.1172/jci131859

N/A

6.6DataRank · unranked

443 citations

Im‐Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu +15 more

The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling

Neuro-Oncology Advances(2020)10.1093/noajnl/vdaa149

N/A

0.606DataRank · unranked

56 citations

Marina da Costa Rosa, Vittorio Stumpo, Rana Rais, Barbara S. Slusher, Gregory J. Riggins +1 more

Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers

Cancer Immunology Research(2024)10.1158/2326-6066.cir-23-1105

N/A

0.590DataRank · unranked

50 citations

Fan Shen, Alex J. Lee, Liang Zhao, Thomas R. Nirschl, Debebe Theodros +18 more

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Disease

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00278

N/A

0.581DataRank · unranked

47 citations

Kristen R. Hollinger, Ajit G. Thomas, Ranjeet Prasad Dash, Carolyn Tallon, Vijayabhaskar Veeravalli +12 more

Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

Theranostics(2020)10.7150/thno.41714

N/A

0.505DataRank · unranked

28 citations

Anjali Sharma, Rajasekhar R. Ramireddy, Ajit G. Thomas, Jesse Alt, Amanda Fowler +7 more

Cocaine-induced locomotor stimulation involves autophagic degradation of the dopamine transporter

Molecular Psychiatry(2021)10.1038/s41380-020-00978-y

N/A

0.483DataRank · unranked

24 citations

Prasun Guha, In Guk Kang, Evan R. Semenza, Adarsha P. Malla, Young Jun Song +9 more

A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

Neuropsychopharmacology(2022)10.1038/s41386-022-01379-1

N/A

0.470DataRank · unranked

22 citations

Guo‐Hua Bi, Benjamin Klein, Briana J. Hempel, Anver Basha Shaik, Emma Gogarnoiu +12 more

A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis

Science Translational Medicine(2023)10.1126/scitranslmed.abn7491

N/A

0.434DataRank · unranked

17 citations

Lauren Norris, Lukáš Tenora, Ivan Šnajdr, András K. Ponti, Xiaolei Zhu +10 more

Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115698

N/A

0.416DataRank · unranked

15 citations

Sarah C. Zimmermann, Run-Duo Gao, Ajit G. Thomas, Filip Kalčic, Vijayabhaskar Veeravalli +7 more

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00734

N/A

0.407DataRank · unranked

10 citations

Ashley N. Nilson, Rebekah Placide, Mimi L. Pham, Franziska M. Jakobs, Noelia Boldizsar +30 more

Essential role of P-glycoprotein in the mechanism of action of oliceridine

Neuropsychopharmacology(2022)10.1038/s41386-022-01507-x

N/A

0.396DataRank · unranked

13 citations

Arianna Rizzo, Juan L. Gomez, Jacob E. Friedman, Sherry Lam, Óscar Solís +4 more

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

Current Drug Metabolism(2021)10.2174/1389200222666210831125041

N/A

0.312DataRank · unranked

7 citations

Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal, Vijayabhaskar Veeravalli, Ying Wu +8 more

Investigating inhibitors of 1-deoxy- d -xylulose 5-phosphate synthase in a mouse model of UTI

Microbiology Spectrum(2024)10.1128/spectrum.03896-23

N/A

0.241DataRank · unranked

4 citations

Rachel Shapiro, Arindom Pal, David Bartee, Kevin DeLong, Davell M. Carter +5 more

Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115674

N/A

0.208DataRank · unranked

3 citations

Ajit G. Thomas, Ondřej Štěpánek, Brennan A. Murphy, Niyada Hin, Jan Skácel +10 more

Inhibition of microglial glutaminase alleviates chronic stress-induced neurobehavioral and cognitive deficits

Neurotherapeutics(2025)10.1016/j.neurot.2025.e00759

N/A

0.208DataRank · unranked

3 citations

Yannan Li, Ajit G. Thomas, A. Sharma, Wathsala Liyanage, Tomáš Tichý +13 more

Prodrugs 2-(Phosphonomethyl)pentanedioic Acid (2-PMPA) as Orally Available Glutamate Carboxypeptidase II Inhibitors

ACS Medicinal Chemistry Letters(2025)10.1021/acsmedchemlett.5c00384

N/A

0.104DataRank · unranked

1 citations

Chae Bin Lee, Sadakatali S. Gori, Barbara S. Slusher, Rana Rais, Takashi Tsukamoto +1 more

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

ChemRxiv(2025)10.26434/chemrxiv-2024-0z6jk-v2

N/A

0.104DataRank · unranked

1 citations

Franziska M. Jacobs, John Hanson, Ashley N. Nilson, Amy E. Moritz, Tian Li +20 more

Exploring the antimicrobial activity of pantothenamides against uropathogenic Escherichia coli

Microbiology Spectrum(2025)10.1128/spectrum.03069-24

N/A

0.104DataRank · unranked

1 citations

David J. Meyers, Arina Ranjit, James Paule, Erika Serrano-Diaz, Kimberly M. Bockley +4 more

Reply to “Letter to the Editor regarding ‘Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone’”

Molecular Psychiatry(2024)10.1038/s41380-024-02864-3

N/A

0.104DataRank · unranked

1 citations

Paulo Alexandre de Oliveira, Nil Casajuana-Martín, César Quiroz, Reece C. Budinich, Rana Rais +15 more

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

Translational Neurodegeneration(2023)10.1186/s40035-023-00383-9

N/A

0DataRank · unranked

24 citations

Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras‐Ortiz, Erden Eren +12 more

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219543120

N/A

0DataRank · unranked

18 citations

Abdül Waheed, Pragney Deme, Şehmus Tohumeken, Rana Rais, Matthew D. Smith +7 more

Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy

Journal of Controlled Release(2023)10.1016/j.jconrel.2023.04.017

N/A

0DataRank · unranked

16 citations

Zhi Zhang, Jesse Alt, Siva P. Kambhampati, Anjali Sharma, Sarabdeep Singh +8 more

Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01681

N/A

0DataRank · unranked

10 citations

Lukáš Tenora, Eva Prchalová, James Paule, Jesse Alt, Vijay Veeravalli +10 more

Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

Neurobiology of Disease(2023)10.1016/j.nbd.2023.105987

N/A

0DataRank · unranked

7 citations

Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher +2 more

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c02037

N/A

0DataRank · unranked

8 citations

Gisela Andrea Camacho‐Hernandez, Kristine Salomon, Kuo Hao Lee, Therese Ku, Jianjing Cao +11 more

Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor

Molecular Cancer Therapeutics(2023)10.1158/1535-7163.mct-23-0258

N/A

0DataRank · unranked

2 citations

Eunüs S. Ali, Marcela Krečmerová, Joanna Marie H. Aguilar, Jesse Alt, Diane E. Peters +11 more

Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand

ACS Chemical Neuroscience(2023)10.1021/acschemneuro.2c00791

N/A

0DataRank · unranked

2 citations

Michelle Taylor, Tamara R. McInnis, Zhenglan Chen, Sadakatali S. Gori, Heather M. LaPorte +9 more

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer’s disease

Research Square(2023)10.21203/rs.3.rs-3131295/v1

N/A

0DataRank · unranked

4 citations

Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras‐Ortiz, Erden Eren +12 more

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.23.529704

N/A

0DataRank · unranked

3 citations

Jessica Shen, Shichun Lun, Liang Zhao, Benjamin Koleske, Robert D. Leone +6 more

Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia

Diabetes(2024)10.2337/db24-0175

N/A

0DataRank · unranked

7 citations

Michael P. Ellenberger, Zachary J. Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira +10 more

Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.21.581451

N/A

0DataRank · unranked

0 citations

Michael P. Ellenberger, Zachary J. Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira +10 more

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

ChemRxiv(2024)10.26434/chemrxiv-2024-0z6jk

N/A

0DataRank · unranked

0 citations

Franziska M. Jacobs, John Hanson, Ashley N. Nilson, Li Tian, Afua B. Faibille +19 more

Targeting NAAG metabolism restores cognition and synaptic integrity in EcoHIV-infected mice

Neurotherapeutics(2025)10.1016/j.neurot.2025.e00782

N/A

0DataRank · unranked

2 citations

Meixiang Huang, R. Michael Maragakis, Peter Pietri, Yu Su, Jesse Alt +7 more

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds

Frontiers in Pharmacology(2025)10.3389/fphar.2025.1646207

N/A

0DataRank · unranked

0 citations

Ajit G. Thomas, John Janiszewski, Nate Hoxie, Chae Bin Lee, Ying Wu +13 more

Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo

Science Advances(2020)10.1126/sciadv.abb4133

N/A

0DataRank · unranked

123 citations

Ling Li, Liyi Xu, Ranjeet Prasad Dash, Neha Gupta, Jenny Lam +9 more

Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112674

N/A

0DataRank · unranked

15 citations

Alessandro Bonifazi, Jianjing Cao, Therese Ku, Alexandra J. Haraczy, Jenny Lam +5 more

Microglia-targeted dendrimer-2PMPA therapy robustly inhibits GCPII and improves cognition in a mouse model of multiple sclerosis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.22.055228

N/A

0DataRank · unranked

1 citations

Anjali Sharma, Carolyn Tallon, Lyndah Lovell, Ajit G. Thomas, Xiaolei Zhu +9 more

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis

Nanotheranostics(2021)10.7150/ntno.63158

N/A

0DataRank · unranked

47 citations

Anjali Sharma, Carolyn Tallon, Lyndah Lovell, Ajit G. Thomas, Xiaolei Zhu +11 more

Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114796

N/A

0DataRank · unranked

42 citations

Silvia Picciolini, Seung‐Wan Yoo, Ajit G. Thomas, Arindom Pal, Jesse Alt +7 more

Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128321

N/A

0DataRank · unranked

8 citations

Niyada Hin, Eva Prchalová, Arindom Pal, Jenny Lam, Rana Rais +3 more

Development of EQ-6, a Novel Analogue of Ethoxyquin to Prevent Chemotherapy-Induced Peripheral Neuropathy

Neurotherapeutics(2021)10.1007/s13311-021-01093-8

N/A

0DataRank · unranked

7 citations

Jing Zhu, Xinghua Luan, Jun-Soon Kim, Byoungchol Oh, Cory Brayton +5 more

Characterization of antipsychotic medications, amino acid signatures, and platelet-activating factor in first-episode psychosis

Biomarkers in Neuropsychiatry(2021)10.1016/j.bionps.2021.100045

N/A

0DataRank · unranked

6 citations

Kun Yang, Ida Shinder, Benjamin C. Orsburn, Rana Rais, Shin‐ichi Kano +3 more

Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity

Translational Psychiatry(2021)10.1038/s41398-021-01547-9

N/A

0DataRank · unranked

5 citations

Aparna Shah, Jacqueline D. Keighron, Ta-Chung M. Mou, Bruce Ladenheim, Jesse Alt +9 more

Clinical development of metabolic inhibitors for oncology

Journal of Clinical Investigation(2022)10.1172/jci148550

N/A

0DataRank · unranked

137 citations

Sadakatali S. Gori, Takashi Tsukamoto, Rana Rais, Barbara S. Slusher, Kathryn M. Lemberg

Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects

Frontiers in Chemistry(2022)10.3389/fchem.2022.889737

N/A

0DataRank · unranked

74 citations

Pavel Majer, Rana Rais, Barbara S. Slusher, Marcela Krečmerová

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Pharmaceutics(2022)10.3390/pharmaceutics14102066

N/A

0DataRank · unranked

27 citations

Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas +10 more

Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata

PNAS Nexus(2022)10.1093/pnasnexus/pgac297

N/A

0DataRank · unranked

13 citations

Sadakatali S. Gori, Jesse Alt, Sandhya P. Tiwari, Jitesh Iyer, Rashmi Talwar +25 more

The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys

Journal of Pharmacology and Experimental Therapeutics(2022)10.1124/jpet.122.001363

N/A

0DataRank · unranked

13 citations

Jianjing Cao, Jenny Lam, Steven R. Childers, Rana Rais, Linda J. Porrino +3 more

Thionated aminofluorophthalimides reduce classical markers of cellular inflammation in LPS-challenged RAW 264.7 cells

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128972

N/A

0DataRank · unranked

2 citations

David Tweedie, Daniela Lecca, Maxime A. Siegler, Rana Rais, Nigel H. Greig +1 more

1119 Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drives tumor immunity in urologic cancers

Regular and Young Investigator Award Abstracts(2022)10.1136/jitc-2022-sitc2022.1119

N/A

0DataRank · unranked

1 citations

Fan Shen, Thomas R. Nirschl, Alex J. Lee, Xiaoxu Wang, Liang Zhao +15 more

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

Nature Communications(2023)10.1038/s41467-023-43304-0

N/A

0DataRank · unranked

35 citations

Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske +7 more

Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone

Molecular Psychiatry(2023)10.1038/s41380-023-02353-z

N/A

0DataRank · unranked

27 citations

Paulo Alexandre de Oliveira, Nil Casajuana-Martín, César Quiroz, Reece C. Budinich, Rana Rais +15 more