🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Nicole J. Lake

Yale University

ORCID: 0000-0003-4103-6387
Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile
4.5Author DataRank

Indexed papers

3in pilot corpus
datarank_citation_only_1hop_v6· scope data_onlyMethodology
Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Top data-sharing exemplar

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Mitochondrial DNA variation across 56,434 individuals in gnomAD

Genome Research(2022)10.1101/gr.276013.121
Top 6%
3.6DataRank
Top 6%156 citations

Nicole J. Lake, Nicholas A. Watts, Megan Shand, Andrea Haessly, Laura D. Gauthier +12 more

Papers

Driven by 16 papers — median percentile 73. Top paper: “Mitochondrial DNA variation across 56,434 individuals in gnomAD”.

Mitochondrial DNA variation across 56,434 individuals in gnomAD

Genome Research(2022)10.1101/gr.276013.121
Top 6%
3.6DataRank
Top 6%156 citations

Nicole J. Lake, Nicholas A. Watts, Megan Shand, Andrea Haessly, Laura D. Gauthier +12 more

Quantifying constraint in the human mitochondrial genome

Nature(2024)10.1038/s41586-024-08048-x
N/A
1.1DataRank · unranked
58 citations

Kaiyue Ma, Wei Liu, Stephanie L. Battle, Kristen M. Laricchia, Grace Tiao +12 more

Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality

Nature Communications(2023)10.1038/s41467-023-41785-7
N/A
1.1DataRank · unranked
44 citations

Stephanie L. Battle, Wen Shi, Daniela Puiu, Vamsee Pillalamarri, Jiaqi Xie +21 more

Mitochondrial DNA variation across 56,434 individuals in gnomAD

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.23.453510
Top 27%
0.757DataRank
Top 27%20 citations

Nicole J. Lake, Nicholas A. Watts, Megan Shand, Andrea Haessly, Laura D. Gauthier +12 more

Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease

Human Molecular Genetics(2023)10.1093/hmg/ddad069
N/A
0.505DataRank · unranked
28 citations

Daniella H. Hock, Nicole J. Lake, Sarah E. Calvo, Sabine Grønborg, Emma Krzesinski +14 more

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

Nature Communications(2024)10.1038/s41467-024-54443-3
N/A
0.360DataRank · unranked
10 citations

Sergiu Paşca, Wen Shi, Daniela Puiu, Nicole J. Lake, Monkol Lek +9 more

A contextual genomic perspective on physical activity and its relationship to health, well being and illness

Nature Genetics(2025)10.1038/s41588-025-02260-9
Top 65%
0.208DataRank
Top 65%3 citations

Daniel F. Levey, Joseph D. Deak, Keyrun Adhikari, Cassie Overstreet, Priya Gupta +11 more

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Nature Genetics(2025)10.1038/s41588-025-02361-5
N/A
0.208DataRank · unranked
3 citations

Aisha Ahmad, Paranchai Boonsawat, Jasmine Shahanoor Hinzen, Mareike Lohse, Boris Bouazza‐Arostegui +95 more

Deleterious heteroplasmic mitochondrial mutations increase risk of overall and cancer-specific mortality

medRxiv(2022)10.1101/2022.09.20.22280151
N/A
0.165DataRank · unranked
2 citations

Yun Soo Hong, Wen Shi, Daniela Puiu, Vamsee Pillalamarri, Nathan Pankratz +5 more

Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases

medRxiv(2024)10.1101/2024.12.22.24319370
N/A
0.104DataRank · unranked
1 citations

Kristen M. Laricchia, Nicole J. Lake, Sushma Chaluvadi, Vijay Ganesh, Stephanie DiTroia +30 more

Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy

Nature Communications(2025)10.1038/s41467-025-65845-2
N/A
0.104DataRank · unranked
1 citations

Kyeezu Kim, Yinan Zheng, Christina A. Castellani, Scott M. Ratliff, Mengyao Wang +41 more

Saturation mutagenesis-reinforced functional assays for disease-related genes

Cell(2024)10.1016/j.cell.2024.08.047
N/A
0DataRank · unranked
21 citations

Shushu Huang, Kenneth Ng, Nicole J. Lake, Soumya Joseph, J. Xu +11 more

Quantifying constraint in the human mitochondrial genome

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.16.520778
N/A
0DataRank · unranked
10 citations

Wei Liu, Stephanie L. Battle, Kristen M. Laricchia, Grace Tiao, Daniela Puiu +9 more

Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus

Med(2020)10.1016/j.medj.2020.06.004
N/A
0DataRank · unranked
72 citations

Alison G. Compton, Yoshihito Kishita, Daniella H. Hock, AnneMarie E. Welch, Sumudu S. C. Amarasekera +40 more

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

medRxiv(2024)10.1101/2024.04.07.24305454
N/A
0DataRank · unranked
0 citations

Sergiu Paşca, Wen Shi, Daniela Puiu, Nicole J. Lake, Monkol Lek +9 more

Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases

Human Genetics and Genomics Advances(2025)10.1016/j.xhgg.2025.100441
N/A
0DataRank · unranked
1 citations

Kristen M. Laricchia, Nicole J. Lake, Sushma Chaluvadi, Vijay Ganesh, Stephanie DiTroia +31 more