Michael J. Emanuele

University of North Carolina at Chapel Hill

Also affiliated with University of North Carolina Health Care, Emanuel University

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 47 papers. Top paper: “Dissenting degradation: Deubiquitinases in cell cycle and cancer”.

Dissenting degradation: Deubiquitinases in cell cycle and cancer

Seminars in Cancer Biology(2020)10.1016/j.semcancer.2020.03.008

N/A

0.727DataRank · unranked

126 citations

Michael J. Emanuele, Thomas Bonacci

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase

Journal of the American Chemical Society(2023)10.1021/jacs.2c11294

N/A

0.520DataRank · unranked

31 citations

Jarrett M. Pelton, Elizaveta T. Wick, Derek L. Bolhuis, Albert S. Baldwin, Michael J. Emanuele +3 more

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

The EMBO Journal(2021)10.15252/embj.2021108823

N/A

0.416DataRank · unranked

15 citations

Derek L. Bolhuis, Anneroos E Nederstigt, Joshua A. Boyer, Brenda Temple, Thomas Bonacci +9 more

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

Cell Reports(2024)10.1016/j.celrep.2024.114510

N/A

0.385DataRank · unranked

12 citations

Kimberly Lukasik, Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang +10 more

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.23.441013

N/A

0.241DataRank · unranked

4 citations

Wayne Stallaert, Elizaveta T. Wick, Peter Ngoi, Seth M. Rubin, Nicholas G. Brown +3 more

Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle

UNC Libraries(2024)10.17615/xekt-8j86

N/A

0.104DataRank · unranked

1 citations

Michael J. Emanuele, Jennifer L. Kernan, Thomas Bonacci

VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1

UNC Libraries(2020)10.17615/0kmt-0310

N/A

0.104DataRank · unranked

1 citations

Rajarshi Choudhury, Xianxi Wang, Kelly Bird, Christine A. Mills, Chunxiao Zhou +5 more

Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation

Frontiers in Cell and Developmental Biology(2021)10.3389/fcell.2021.687515

N/A

0DataRank · unranked

27 citations

Kaeli A. Welsh, Megan Hinkle, Michael J. Emanuele, Nicholas G. Brown, Tatyana Bodrug

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

Cancers(2023)10.3390/cancers15020517

N/A

0DataRank · unranked

26 citations

Derek L. Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang +4 more

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian Cancer

International Journal of Molecular Sciences(2023)10.3390/ijms241512375

N/A

0DataRank · unranked

18 citations

Yali Fan, Ziyi Zhao, Xin Zhang, Katherine L. Tucker, Allison Staley +11 more

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

Nature Structural & Molecular Biology(2023)10.1038/s41594-023-01105-5

N/A

0DataRank · unranked

18 citations

Kaeli A. Welsh, Derek L. Bolhuis, Ethan Paulаkonis, Raquel C. Martinez‐Chacin, Bei Liu +16 more

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.11.561963

N/A

0DataRank · unranked

1 citations

Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang, Christine A. Mills +8 more

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

UNC Libraries(2023)10.17615/1wht-0y96

N/A

0DataRank · unranked

0 citations

Yu Le, Derek L. Bolhuis, Xiaodong Wang, Nicholas G. Brown, Michael J. Emanuele +4 more

4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20

Cellular and Molecular Immunology(2024)10.1038/s41423-024-01198-y

N/A

0DataRank · unranked

18 citations

Thomas Raphael Bonacci, Peishun Shou, Elisa Landoni, Mark G. Woodcock, Chuang Sun +9 more

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Biochemical Society Transactions(2024)10.1042/bst20230454

N/A

0DataRank · unranked

12 citations

Michael J. Emanuele, Nicholas G. Brown, Derek L. Bolhuis

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Nature Communications(2024)10.1038/s41467-024-46644-7

N/A

0DataRank · unranked

7 citations

Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie +18 more

Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates

UNC Libraries(2024)10.17615/wx15-j073

N/A

0DataRank · unranked

9 citations

Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci, Aussie Suzuki, Jeanette Gowen Cook +2 more

Dissenting degradation: Deubiquitinases in cell cycle and cancer

UNC Libraries(2024)10.17615/js9j-d637

N/A

0DataRank · unranked

2 citations

Thomas Bonacci, Michael J. Emanuele

Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1

UNC Libraries(2024)10.17615/k601-kt77

N/A

0DataRank · unranked

1 citations

Kaeli A. Welsh, Raquel C. Martinez‐Chacin, Nicholas G. Brown, Tatyana Bodrug, Liying Cui +2 more

Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity

UNC Libraries(2024)10.17615/9kz2-x510

N/A

0DataRank · unranked

1 citations

Michael J. Emanuele, Deepak Kumar Jha, L. Stirling Churchman, W. Kimryn Rathmell, Rajarshi Choudhury +6 more

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.28.596309

N/A

0DataRank · unranked

1 citations

Derek L. Bolhuis, Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

UNC Libraries(2024)10.17615/3djv-bv96

N/A

0DataRank · unranked

0 citations

Wayne Stallaert, Taylor P. Enrico, Jeremy E. Purvis, Nicholas G. Brown, Seth M. Rubin +4 more

Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells

UNC Libraries(2024)10.17615/bmvq-pm20

N/A

0DataRank · unranked

0 citations

Laura E. Herring, Michael P. East, Cyrus Vaziri, Dennis Goldfarb, Emily Wilkerson +7 more

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

UNC Libraries(2024)10.17615/cr0z-4y62

N/A

0DataRank · unranked

0 citations

Charles D. Schwieters, Rolf E. Swenson, V. Keith Hughitt, Raj Chari, Venkata R. Sabbasani +18 more

Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer

UNC Libraries(2024)10.17615/90en-6z38

N/A

0DataRank · unranked

0 citations

Richard G. Hodge, Jacob E. Larson, Michael J. Emanuele, Stephen V. Frye, McKenzie P. Kline +12 more

Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin

UNC Libraries(2024)10.17615/t4yh-ee87

N/A

0DataRank · unranked

0 citations

Danit Wasserman, Taylor P. Enrico, Amit Tzur, Ryan D. Mouery, Michael J. Emanuele +1 more

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

UNC Libraries(2024)10.17615/sqdv-t262

N/A

0DataRank · unranked

0 citations

Michael J. Emanuele, Nicholas G. Brown, Derek L. Bolhuis

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

UNC Libraries(2024)10.17615/s94d-5j87

N/A

0DataRank · unranked

0 citations

Brenda Temple, Joshua P. Steimel, Li H. Gu, Anneroos E Nederstigt, Nicholas G. Brown +9 more

Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation

UNC Libraries(2024)10.17615/xfke-wz53

N/A

0DataRank · unranked

0 citations

Nicholas G. Brown, Michael J. Emanuele, Tatyana Bodrug, Megan Hinkle, Kaeli A. Welsh

Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation

UNC Libraries(2024)10.17615/ee5m-8460

N/A

0DataRank · unranked

0 citations

Aussie Suzuki, Michael J. Emanuele, Christine A. Mills, Jin Yao Mo, Edward D. Salmon +2 more

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

UNC Libraries(2024)10.17615/xm7a-6j77

N/A

0DataRank · unranked

0 citations

Thomas Bonacci, Liying Cui, Sascha Josef Amann, William Zhang, Kaeli A. Welsh +16 more

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

UNC Libraries(2024)10.17615/5fdn-2z74

N/A

0DataRank · unranked

0 citations

Tatyana Bodrug, Morgan E. Gibbs, Jan‐Michael Peters, Michael J. Emanuele, Jeanette Gowen Cook +10 more

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.03.610997

N/A

0DataRank · unranked

0 citations

Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook +3 more

4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20

UNC Libraries(2024)10.17615/cwee-c688

N/A

0DataRank · unranked

0 citations

Zhangqi Dou, Laura E. Herring, Yisong Y. Wan, Albert S. Baldwin, Feifei Song +9 more

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

UNC Libraries(2024)10.17615/jj32-v329

N/A

0DataRank · unranked

0 citations

Derek L. Bolhuis, Xianxi Wang, Ryan D. Mouery, E Drew Toomer, Timothy B. Branigan +10 more

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase

UNC Libraries(2024)10.17615/zv55-rv74

N/A

0DataRank · unranked

0 citations

Sabrina E. Iskandar, Jarrett M. Pelton, Nicholas G. Brown, Elizaveta T. Wick, Michael J. Emanuele +3 more

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

Nature(2025)10.1038/s41586-025-09328-w

N/A

0DataRank · unranked

10 citations

Derek L. Bolhuis, Hualong Yan, Sudipto Das, Xia Xu, Christina C. Abbate +8 more

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

Nature Communications(2025)10.1038/s41467-025-59770-7

N/A

0DataRank · unranked

5 citations

Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook +3 more

Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110288

N/A

0DataRank · unranked

2 citations

Derek L. Bolhuis, Nicholas G. Brown, Michael J. Emanuele, Thomas Bonacci

DIG-DUBs: mechanisms and functions of ISG15 deconjugation by human and viral cross-reactive ubiquitin proteases

Biochemical Society Transactions(2025)10.1042/bst20240859

N/A

0DataRank · unranked

1 citations

Michael J. Emanuele, Thomas Bonacci

Charting the Multi-level Molecular Response to Palbociclib in ER-Positive Breast Cancer

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.27.672587

N/A

0DataRank · unranked

1 citations

Amy Aponte, M.H.F. Sullivan, Sarah L. Whittington, José C. Martínez, Grant A. Goda +4 more

Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin

Trends in Cell Biology(2020)10.1016/j.tcb.2020.05.002

N/A

0DataRank · unranked

79 citations

Taylor P. Enrico, Ryan D. Mouery, Danit Wasserman, Sapir Nachum, Amit Tzur +1 more

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

PLoS Biology(2020)10.1371/journal.pbio.3000975

N/A

0DataRank · unranked

21 citations

Raquel C. Martinez‐Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury +13 more

Sirtuin 5 Is Regulated by the SCF Cyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control

Molecular and Cellular Biology(2020)10.1128/mcb.00269-20

N/A

0DataRank · unranked

11 citations

Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob P. Matson, Debojyoti Lahiri +5 more

Mass spectrometry–based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells

Journal of Biological Chemistry(2020)10.1074/jbc.ra119.011083

N/A

0DataRank · unranked

30 citations

Gavin D. Grant, Michael P. East, Thomas S.K. Gilbert, Emily Wilkerson, Dennis Goldfarb +7 more

SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development

UNC Libraries(2020)10.17615/fffc-d252

N/A

0DataRank · unranked

4 citations

Feng Yan, Dennis Goldfarb, Bernard E. Weissman, Yasumichi Kuwahara, Shujie Song +5 more

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.09.033621

N/A

0DataRank · unranked

1 citations

Raquel C. Martinez‐Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury +11 more