Florence Lai

Also affiliated with University of California, Irvine, Harvard University Press, Glenfield Hospital, Massachusetts General Hospital, Rome Foundation, Dana-Farber/Harvard Cancer Center, Irvine University, NIHR Leicester Biomedical Research Centre

Medicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 4%percentile

0.674Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12039

Top 30%

0.674DataRank

Top 30%23 citations

Fan Zhang, Nicole Schupf, Sharon J. Krinsky‐McHale, James Hall, Mark Mapstone +18 more

Papers

Driven by 34 papers — median percentile 70. Top paper: “Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study”.

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

The Lancet Neurology(2022)10.1016/s1474-4422(22)00408-2

N/A

1.1DataRank · unranked

56 citations

Brian A. Gordon, Julie K. Wisch, Shaney Flores, Rachel L. Henson, Omar H. Butt +95 more

Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12039

Top 30%

0.674DataRank

Top 30%23 citations

Fan Zhang, Nicole Schupf, Sharon J. Krinsky‐McHale, James Hall, Mark Mapstone +18 more

The Alzheimer's Biomarker Consortium–Down Syndrome (ABC‐DS): A 10‐year report

Alzheimer s & Dementia(2025)10.1002/alz.70294

N/A

0.601DataRank · unranked

22 citations

Mark Mapstone, Sigan L. Hartley, Howard Andrews, Brad T. Christian, Joseph H. Lee +20 more

Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome

Journal of Alzheimer s Disease(2020)10.3233/jad-201167

N/A

0.598DataRank · unranked

53 citations

Michael S. Rafii, Fan Zhang, James Hall, David Julovich, Beau M. Ances +20 more

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

The Lancet Neurology(2024)10.1016/s1474-4422(24)00084-x

N/A

0.542DataRank · unranked

36 citations

Nicole S. McKay, Anna H. Boerwinkle, James L. Kennedy, Shaney Flores, Benjamin L. Handen +86 more

Cerebrovascular disease is associated with Alzheimer’s plasma biomarker concentrations in adults with Down syndrome

Brain Communications(2024)10.1093/braincomms/fcae331

N/A

0.510DataRank · unranked

29 citations

Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa Petersen +70 more

Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study

The Lancet Neurology(2024)10.1016/s1474-4422(24)00426-5

N/A

0.505DataRank · unranked

28 citations

Matthew Zammit, Jiebiao Wang, Benjamin L. Handen, Tobey J. Betthauser, Charles M. Laymon +71 more

Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer’s continuum

SLEEP Advances(2022)10.1093/sleepadvances/zpac013

N/A

0.457DataRank · unranked

20 citations

Molly E. Zimmerman, Sigan L. Hartley, José Gutierrez, David B. Keator, Kay C. Igwe +16 more

Gut dysbiosis in Down syndrome: A potentially unexplored culprit for early Alzheimer's disease

Alzheimer s & Dementia(2025)10.1002/alz.70330

N/A

0.345DataRank · unranked

9 citations

Xochitl C. Morgan, Yiran Tao, Florence Lai, Nathaniel D. Mercaldo, H. Diana Rosas

Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2024)10.1002/dad2.70023

N/A

0.269DataRank · unranked

5 citations

Nathaniel D. Mercaldo, Yasemin Hasimoglu, Melissa Petersen, Lydia R. Lewis, Florence Lai +8 more

Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome

Alzheimer s & Dementia(2025)10.1002/alz.70726

N/A

0.241DataRank · unranked

4 citations

Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa Petersen +20 more

The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer’s disease

Brain(2025)10.1093/brain/awaf428

N/A

0.165DataRank · unranked

2 citations

Hailey Bruzzone, Karly Alex Cody, Jacob Morse, Rachael E. Wilson, Brecca Bettcher +65 more

The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome

EBioMedicine(2024)10.1016/j.ebiom.2024.105433

N/A

0DataRank · unranked

6 citations

Lam‐Ha T. Dang, Alice Lee, Sharon J. Krinsky‐McHale, Deborah Pang, Lisa Melilli +72 more

A pathway linking pulse pressure to dementia in adults with Down syndrome

Brain Communications(2024)10.1093/braincomms/fcae157

N/A

0DataRank · unranked

3 citations

Patrick J. Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan +17 more

Increased fibrin deposition in the brains of individuals with Down syndrome and Alzheimer’s disease

Alzheimer s & Dementia(2024)10.1002/alz.089882

N/A

0DataRank · unranked

0 citations

Lisi Flores Aguilar, Natalie C. Edwards, Patrick J. Lao, Jae Kyu Ryu, Katerina Akassoglou +7 more

Regional differences in astrocytic Aquaporin-4 protein levels and distribution in aging and Alzheimer's disease in down syndrome

Neurobiology of Disease(2025)10.1016/j.nbd.2025.107114

N/A

0DataRank · unranked

7 citations

Haley Miyasato, Kevin Camey, Krina A Ghadia, Elizabeth J. Andrews, Phong Ngo +17 more

A neuropathology case report of a woman with Down syndrome who remained cognitively stable: Implications for resilience to neuropathology

Alzheimer s & Dementia(2025)10.1002/alz.14479

N/A

0DataRank · unranked

14 citations

Jerry J. Lou, Lisi Flores Aguilar, Jamie Nakagiri, William H. Yong, Christy Hom +19 more

Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI

Journal of Neuropathology & Experimental Neurology(2025)10.1093/jnen/nlaf010

N/A

0DataRank · unranked

6 citations

Jinghang Li, Jacob Berardinelli, Hecheng Jin, Tales Santini, Jaehoon Noh +69 more

Age and sex are associated with Alzheimer's disease neuropathology in Down syndrome

Alzheimer s & Dementia(2025)10.1002/alz.70408

N/A

0DataRank · unranked

4 citations

Phong Ngo, Jesse R. Pascual, Freddy Gonzalez, Michael Phelan, Sierra Wright +9 more

A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials

Brain Communications(2025)10.1093/braincomms/fcaf406

N/A

0DataRank · unranked

2 citations

Julie C. Price, Bradley T. Christian, Michael S. Rafii, Beau M. Ances, Howard Andrews +51 more

Imaging and plasma biomarkers for pathological accumulation in Down syndrome

Brain(2025)10.1093/brain/awaf418

N/A

0DataRank · unranked

2 citations

Ziqiao Jiao, James T. Kennedy, Ann D. Cohen, Zinayida Schlachetzki, Melissa Petersen +21 more

The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodology

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12065

N/A

0DataRank · unranked

122 citations

Ira T. Lott, Bradley T. Christian, Nicole Schupf, Sid E. O’Bryant, Mark Mapstone +17 more

Blood‐brain barrier integrity and vessel morphology in adults with Down syndrome and Alzheimer's neuropathology

Alzheimer s & Dementia(2025)10.1002/alz70855_106199

N/A

0DataRank · unranked

0 citations

Jesse R. Pascual, Halyma Nguyen, Annie Du, Natalie C. Edwards, Patrick J. Lao +9 more

Alzheimer‐related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12040

N/A

0DataRank · unranked

19 citations

Eugene Hsu, Nathaniel D. Mercaldo, Florence Lai, Margaret B. Pulsifer, David B. Keator +9 more

Sex differences in risk of Alzheimer's disease in adults with Down syndrome

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12084

N/A

0DataRank · unranked

30 citations

Pooja G. Mhatre, Yuchen Yang, Mei‐Cheng Wang, Nicole Schupf, H. Diana Rosas +1 more

Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study

The Lancet Neurology(2021)10.1016/s1474-4422(21)00139-3

N/A

0DataRank · unranked

71 citations

Rachel L. Henson, Yan Li, Anna H. Boerwinkle, Chengjie Xiong, Randall J. Bateman +29 more

Association between Inflammatory Conditions and Alzheimer’s Disease Age of Onset in Down Syndrome

Journal of Clinical Medicine(2021)10.3390/jcm10143116

N/A

0DataRank · unranked

11 citations

Nathaniel D. Mercaldo, Cassandra M. Wang, Giovi G. Hersch, H. Diana Rosas, Florence Lai

Alterations in white matter integrity in cognitively stable Down syndrome correlate with plasma neurofilament light chain: Evidence of early myelin breakdown

Alzheimer s & Dementia(2021)10.1002/alz.056379

N/A

0DataRank · unranked

0 citations

Yasemin Hasimoglu, Nathaniel D. Mercaldo, Florence Lai, Melissa Petersen, Adam M. Brickman +7 more

Weight Loss and Alzheimer’s Disease in Down Syndrome

Journal of Alzheimer s Disease(2022)10.3233/jad-220865

N/A

0DataRank · unranked

12 citations

Brian C. Helsel, Lauren T. Ptomey, H. Diana Rosas, Benjamin L. Handen, Charles M. Laymon +10 more

Probing the proteome to explore potential correlates of increased Alzheimer's‐related cerebrovascular disease in adults with Down syndrome

Alzheimer s & Dementia(2022)10.1002/alz.12627

N/A

0DataRank · unranked

12 citations

Melissa Petersen, Fan Zhang, Patrick J. Lao, Molly E. Zimmerman, Yian Gu +19 more

Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome

medRxiv(2023)10.1101/2023.11.28.23298693

N/A

0DataRank · unranked

10 citations

Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa Petersen +20 more

Pathways linking pulse pressure to dementia in adults with Down syndrome

medRxiv(2023)10.1101/2023.10.26.23297625

N/A

0DataRank · unranked

0 citations

Patrick J. Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan +17 more

Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome

Alzheimer s & Dementia(2024)10.1002/alz.13778

N/A

0DataRank · unranked

18 citations

Richard A. Fisher, Matthew P. Janicki, Brian Chicoine, Bradley T. Christian, Anna J. Esbensen +17 more

Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2024)10.1002/dad2.12582

N/A

0DataRank · unranked

16 citations

Benjamin L. Handen, Melissa Petersen, Sid E. O’Bryant, Jamie C. Peven, Dana Tudorascu +17 more

Florence Lai

Indexed papers

Top data-sharing exemplar

Papers