Jessica L. Childs‐Disney

Biochemistry, Genetics and Molecular BiologyNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 32 papers. Top paper: “Targeting RNA structures with small molecules”.

Targeting RNA structures with small molecules

Nature Reviews Drug Discovery(2022)10.1038/s41573-022-00521-4

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7.2DataRank · unranked

598 citations

Xueyi Yang, Quentin M. R. Gibaut, Yuquan Tong, Robert Batey, Matthew D. Disney +1 more

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G 4 C 2 ) exp in c9ALS/FTD via the nuclear RNA exosome

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2210532119

N/A

0.477DataRank · unranked

23 citations

Samantha M. Meyer, Rita Fuerst, Yuquan Tong, Yue Li, Raphael I. Benhamou +11 more

Design of an Orally Bioavailable Small Molecule That Modulates the Microtubule-Associated Protein Tau’s Pre-mRNA Splicing

ACS Chemical Biology(2025)10.1021/acschembio.5c00260

N/A

0.104DataRank · unranked

1 citations

Amirhossein Taghavi, Masahito Abe, Haruo Aikawa, Yoshihiro Akahori, Jonathan L. Chen +6 more

Progress toward the development of the small molecule equivalent of small interfering RNA

Current Opinion in Chemical Biology(2020)10.1016/j.cbpa.2020.01.001

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0DataRank · unranked

17 citations

Blessy M. Suresh, Raphael I. Benhamou, Jessica L. Childs‐Disney, Matthew D. Disney

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models

Science Translational Medicine(2021)10.1126/scitranslmed.abd5991

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0DataRank · unranked

80 citations

Haruo Aikawa, Rita Fuerst, Yue Li, Andrei Ursu, Samantha M. Meyer +19 more

A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00414

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0DataRank · unranked

17 citations

Masahito Abe, Raphael I. Benhamou, Alicia J. Angelbello, Kamalakannan Vishnu, Jonathan L. Chen +3 more

Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA

Journal of the American Chemical Society(2022)10.1021/jacs.2c01929

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0DataRank · unranked

75 citations

Quentin M. R. Gibaut, Warren B. Rouse, Jessica L. Childs‐Disney, Blessy M. Suresh, Daniel Abegg +6 more

A meditation on accelerating the development of small molecule medicines targeting RNA

Expert Opinion on Drug Discovery(2022)10.1080/17460441.2022.2084528

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0DataRank · unranked

4 citations

Jessica L. Childs‐Disney, Matthew D. Disney, Xueyi Yang

Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy

ACS Central Science(2023)10.1021/acscentsci.2c01223

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0DataRank · unranked

26 citations

Jessica A. Bush, Yuquan Tong, Jared T. Baisden, Amirhossein Taghavi, Hailey Olafson +5 more

Fragment-Based Approaches to Identify RNA Binders

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00034

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0DataRank · unranked

23 citations

Amirhossein Taghavi, Jessica L. Childs‐Disney, Matthew D. Disney, Blessy M. Suresh

Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity

ACS Chemical Biology(2023)10.1021/acschembio.3c00363

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0DataRank · unranked

15 citations

Yuquan Tong, Daniel Abegg, Alexander Adibekian, Jessica L. Childs‐Disney, Matthew D. Disney +1 more

Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies

Nucleic Acids Research(2023)10.1093/nar/gkad403

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0DataRank · unranked

13 citations

Jared T. Baisden, Jessica L. Childs‐Disney, Ilyas Yildirim, Matthew D. Disney, Amirhossein Taghavi

DNA‐Encoded Libraries and Their Application to RNA

Israel Journal of Chemistry(2023)10.1002/ijch.202300073

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0DataRank · unranked

13 citations

Jessica L. Childs‐Disney, M. Paegel, Matthew D. Disney, Xueyi Yang

Broad-spectrum metastasis suppressing compounds and therapeutic uses thereof in human tumors

Scientific Reports(2023)10.1038/s41598-023-47478-x

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0DataRank · unranked

3 citations

Jonathan L. Chen, Jessica L. Childs‐Disney, Matthew D. Disney, Dan Canaani, Pnina Gottfried Komlosh

Conformational Dynamics of RNA G4C2 and C2G4 Repeat Expansions causing ALS/FTD using NMR and Molecular Dynamics Studies

ChemRxiv(2023)10.26434/chemrxiv-2023-3g7w7

N/A

0DataRank · unranked

0 citations

Amirhossein Taghavi, Jared T. Baisden, Jessica L. Childs‐Disney, Ilyas Yildirim, Matthew D. Disney

Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2306682120

N/A

0DataRank · unranked

47 citations

Peiyuan Zhang, Xueyi Yang, Xiaohui Liu, Jie Zhang, Magda Grudniewska +10 more

Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40

British Journal of Pharmacology(2024)10.1111/bph.17308

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0DataRank · unranked

22 citations

Jessica L. Childs‐Disney, Matthew D. Disney, Yuquan Tong

Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras

Journal of the American Chemical Society(2024)10.1021/jacs.4c04717

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0DataRank · unranked

19 citations

Xiaoxuan Su, Warren B. Rouse, Jessica L. Childs‐Disney, Amirhossein Taghavi, Patrick R. A. Zanon +5 more

Protocol for transcriptome-wide mapping of small-molecule RNA-binding sites in live cells

STAR Protocols(2024)10.1016/j.xpro.2024.103271

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0DataRank · unranked

9 citations

Patrick R. A. Zanon, Xueyi Yang, Xiaoxuan Su, Jessica L. Childs‐Disney, Matthew D. Disney +1 more

Heterobifunctional small molecules to modulate RNA function

Trends in Pharmacological Sciences(2024)10.1016/j.tips.2024.03.006

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0DataRank · unranked

9 citations

Yuquan Tong, Jessica L. Childs‐Disney, Matthew D. Disney, Sandra Kovachka

NMR structures of small molecules bound to a model of a CUG RNA repeat expansion

Bioorganic & Medicinal Chemistry Letters(2024)10.1016/j.bmcl.2024.129888

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0DataRank · unranked

6 citations

Amirhossein Taghavi, Alexander J. Frank, Matthew A. Fountain, Shruti Choudhary, Soma Roy +3 more

NMR structures of small molecules bound to a model of an RNA CUG repeat expansion

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.21.600119

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0DataRank · unranked

2 citations

Amirhossein Taghavi, Alexander J. Frank, Matthew A. Fountain, Shruti Choudhary, Soma Roy +3 more

NMR structures and magnetic force spectroscopy studies of small molecules binding to models of an RNA CAG repeat expansion

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.20.608150

N/A

0DataRank · unranked

0 citations

Jonathan L. Chen, Zhen Wang, Krishshanthi Sinnadurai, David Georges Salthouse, Matthew Ozon +6 more

The evolution and application of RNA-focused small molecule libraries

RSC Chemical Biology(2025)10.1039/d4cb00272e

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0DataRank · unranked

17 citations

Noah A. Springer, Patrick R. A. Zanon, Yanjun Li, Chenglong Li, Jessica L. Childs‐Disney +2 more

Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design

Journal of the American Chemical Society(2025)10.1021/jacs.5c11898

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0DataRank · unranked

8 citations

Jielei Wang, Amirhossein Taghavi, Yilin Jia, Taro Asaba, Karen C. Wolff +14 more

A Live-Cell NanoBRET Assay to Monitor RNA–Protein Interactions and Their Inhibition by Small Molecules

ACS Central Science(2025)10.1021/acscentsci.5c00705

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0DataRank · unranked

2 citations

Amirhossein Taghavi, Elizabeth A. Caine, Ryuichi Sekioka, Veronika Rajchin, James M. Burke +4 more

Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00749

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0DataRank · unranked

5 citations

Sandra Kovachka, Tenghui Wang, Michael D. Cameron, Jessica L. Childs‐Disney, Matthew D. Disney +1 more

Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation

Journal of the American Chemical Society(2025)10.1021/jacs.5c14363

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0DataRank · unranked

1 citations

Yuquan Tong, Patrick R. A. Zanon, Jielei Wang, Toru Tanaka, Jessica L. Childs‐Disney +2 more

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1914286117

N/A

0DataRank · unranked

187 citations

Haruo Aikawa, Yue Li, Jessica L. Childs‐Disney, Daniel Abegg, Dominic G. Hoch +9 more

Design of an orally bioavailable small molecule that modulates the microtubule-associated protein tau’s pre-mRNA splicing

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.30.651234

N/A

0DataRank · unranked

0 citations

Amirhossein Taghavi, Masahito Abe, Haruo Aikawa, Yoshihiro Akahori, Jonathan L. Chen +6 more

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1905057117

N/A

0DataRank · unranked

121 citations

Hye-Jin Park, Jie Zhang, Eunsung Junn, Ryan J. Andrews, Sai Pradeep Velagapudi +9 more

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Journal of the American Chemical Society(2020)10.1021/jacs.0c00768

N/A

0DataRank · unranked

81 citations

Peiyuan Zhang, Masahito Abe, Haruo Aikawa, Liying Zhang, Alexander J. Frank +14 more