What Happens When Underperforming Big Ideas in Research Become Entrenched? is a research paper published in JAMA (2016). On theSindex it has a DataRank of 0.666. It has been cited 84 times.
In this Viewpoint, John Ioannidis and colleagues review how rarely gene therapy and genomic medicine have led to breakthroughs for patients and call on the NIH to defund preclinical research that fails to deliver on its initial promise.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.666
From this paper's citation signal
Citation Network Contribution
0
Citation network not refreshed for this result
This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.
Learn more about DataRank methodology →DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 100% comes from its base citations and 0% from the citation network.
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.