Centrosome in Cell Division, Development and Disease is a research paper published in Encyclopedia of Life Sciences (2016). On theSindex it has a DataRank of 0.526. It has been cited 10 times, with 6 citing works in its 1-hop citation network.
Abstract The centrosome is a non‐membrane‐bound organelle present in most animal cells and it functions as the major microtubule‐organising centre (MTOC). Recent findings have revealed the detailed molecular and structural features of the centrosome, and architectural and functional changes at the centrosome during the cell cycle. The centriole, the organisational heart of the centrosome, duplicates once each cell cycle and depends on a hierarchy of regulatory and assembly factors for its biogenesis. The centrosome plays important roles in dividing and nondividing cells. This importance is reflected in the appearance of several human developmental disorders when genes encoding centrosomal proteins are mutated. The centriole is essential for the formation of cilia, the cell's ‘antennae’ that receive and transmit signals and sensory inputs critical for animal development and physiology. Impairment of cilium structure or function leads to a spectrum of diseases called ciliopathies. Key Concepts The centrosome typically contains a centriole pair, the mother and its daughter, and the pericentriolar material (PCM). Centrioles have a ninefold radial symmetry and are required for organising a functional centrosome. The PCM is a large multi‐protein complex that regulates microtubule (MT) assembly at centrosomes in dividing and nondividing cells. Centrioles duplicate only once each cell cycle, and the protein kinase PLK4 is a key early regulator of centriole duplication and biogenesis. The cartwheel at the proximal end of the centriole is assembled early in centriole biogenesis, and its ninefold symmetry is determined by the intrinsic properties of the key structural protein Sas‐6. The centrosome is involved in the asymmetric division of stem cells. In nondividing cells, the basal body, a modified mother centriole, serves as a platform for organising the MT‐based axoneme, forming a primary or motile cilium. Most vertebrate cells contain a primary cilium that is critical for signalling pathways including Hedgehog (Hh) signalling and left–right asymmetry designation during development. Centrosomal and ciliary dysfunctions have been linked to two types of diseases: microcephaly/primordial dwarfisms, and ciliopathies, respectively.
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Base Score Contribution
0.360
From this paper's citation signal
Citation Network Contribution
0.166
From 4 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 68% comes from its base citations and 32% from the citation network (4 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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