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Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science(2025)10.1002/advs.202510780Source: DataRank Database

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors is a research paper published in Advanced Science (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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0DataRank · unranked

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Open Access1 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.62)OA: goldTopics (45)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Riya Gupta ORCID,Yosuke M. Morizawa ORCID,Yu Qin ORCID,Xingyu Du,C. Hor-Nay Pang

Live enrichment

PubMed:41319285 PMC:PMC12904067 OpenAlex:https://openalex.org/W4416829491

National Institutes of Health

Grant: GM131765

NIGMS NIH HHS

Grant: R35 GM131765

Columbia University Department of Anesthesiology

FWCI

0.62

Citation Percentile

0.7%

Citation Trend

2026

goldLicense: cc-by

journalhttps://doi.org/10.1002/advs.202510780

publisherhttps://doi.org/10.1002/advs.202510780

publisherhttps://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202510780

publisherhttps://advanced.onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.202510780

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41319285

Fields of Study

Endoplasmic Reticulum Stress and DiseaseNeurogenesis and neuroplasticity mechanismsTryptophan and brain disordersAnimalsPrefrontal CortexAstrocytesMiceeIF-2 KinaseDisease Models, AnimalMajor Depressive DisorderMaleHumansMice, Inbred C57BLFemaleEndoplasmic Reticulum StressDepressionThrombospondin 1

MeSH Terms

AnimalsAstrocytesDepressionMajor Depressive DisorderDisease Models, AnimalFemaleHumansMaleMice, Inbred C57BLPrefrontal CortexThrombospondin 1eIF-2 KinaseMiceEndoplasmic Reticulum Stress

Keywords

Prefrontal cortexDownregulation and upregulationEndoplasmic reticulumUnfolded protein responseDendritic spineNeuroplasticityAstrocytePhenotypeGene therapySynaptic plasticityDepressionNRF2pERKTsp1