Primary lateral sclerosis associated with PSEN1 Pro284Leu variant in a Colombian family: Clinical and neuropathological features is a dataset published in Alzheimer s & Dementia (2024). On theSindex it has a DataRank of 0.269, placing it in the top 57.9% of the data-sharing corpus. It has been cited 4 times, with 3 citing works in its 1-hop citation network. Its calibrated FAIR score is 58/100.
Ranks in the top 58% for downstream scientific impact
Linked data & code
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
“Histological images from the comprehensive neuropathological analyses of Cases 1 and 2 are available at the CIL Cell Image Library (DOI: https://doi.org/10.7295/W9P20489).”
The paper provides a DOI for the dataset, which is a persistent identifier.
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“Histological images from the comprehensive neuropathological analyses of Cases 1 and 2 are available at the CIL Cell Image Library”
The repository 'CIL Cell Image Library' is named as the holder of the data.
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
“Histological images from the comprehensive neuropathological analyses of Cases 1 and 2 are available at the CIL Cell Image Library (DOI: https://doi.org/10.7295/W9P20489).”
The dataset identifier (DOI) appears only in the body text, not in the reference list.
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“Histological images from the comprehensive neuropathological analyses of Cases 1 and 2 are available at the CIL Cell Image Library (DOI: https://doi.org/10.7295/W9P20489).”
The statement points to a repository record with a DOI (Colavizza category 3).
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“Histological images from the comprehensive neuropathological analyses of Cases 1 and 2 are available at the CIL Cell Image Library (DOI: https://doi.org/10.7295/W9P20489).”
The dataset content is described only in running prose, without an itemised inventory or section heading. [majority verdict 'partial' (3/5 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“Histological images from the comprehensive neuropathological analyses of Cases 1 and 2 are available at the CIL Cell Image Library (DOI: https://doi.org/10.7295/W9P20489).”
The data are stated to be available at a repository with no precondition on access (only reuse conditions). [majority verdict 'yes' (3/5 passes agreed)]
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“These materials may be used and shared by anyone, provided that they are not modified, used for non-commercial purposes only, and that the original authors are duly credited and cited.”
The paper describes access conditions but does not use a standard label like 'open access'. [majority verdict 'partial' (4/5 passes agreed)]
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
No gatekeeper is named; the data are available with a license but no institutional access committee.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
No statement about retention period or availability timing is given.
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
No file format is named for the deposited data.
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
“The ABC score was A3 B3 C3, corresponding to 'high-level AD neuropathologic change' according to the 2012 National Institute on Aging/Alzheimer's Association (NIA/AA) guidelines.”— not found in the paper; verdict downgraded
The NIA/AA guidelines are a community standard for neuropathological assessment. [downgraded to 'partial' — no verifiable quote from the paper]
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
“PSEN1 NM_000021.4 c.851C > T p.Pro284Leu (rs63750863)”
The paper provides an rs number (dbSNP identifier) for the variant, which is an identifier for an external resource. [majority verdict 'yes' (3/5 passes agreed)]
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
“These materials may be used and shared by anyone, provided that they are not modified, used for non-commercial purposes only, and that the original authors are duly credited and cited.”
The data reuse conditions are described but not named as a standard license or a named terms artefact. [majority verdict 'no' (3/5 passes agreed)]
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
No version token or date is provided to identify the snapshot of the data.
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
No code is mentioned or made available.
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“National Institutes of Health (NIH) grant 1RF1AG062479-01*** (F.L., K.S.K., T.G.B., and C.LW.) and R01AG054671 (Y.T.Q. and F.L.)”
Award numbers are provided for the funding. [majority verdict 'yes' (4/5 passes agreed)]
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“Magnetic resonance imaging (MRI) of the brain and spinal cord were done on a 3T Siemens Skyra machine”
The paper names specific instruments, such as the 3T Siemens Skyra machine. [majority verdict 'yes' (3/5 passes agreed)]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
No documentation object like a README or codebook is mentioned as accompanying the data. [majority verdict 'no' (4/5 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.241
From this paper's citation signal
Citation Network Contribution
0.0275
From 1 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 3 citers.
National Institutes of Health
Grant: 1RF1AG062479‐01***
National Institutes of Health
Grant: R01AG054671
National Institutes of Health
Grant: RF1AG077627
National Institutes of Health
Grant: RM1NS132996
NIA NIH HHS
Grant: RF1 AG062479
NIH HHS
Grant: 1RF1AG062479-01***
National Institutes of Health
Grant: 1RF1AG077627-01
Nerve growth factor (NGF) metabolic dysfunction as a marker of cognitive decline in autosomal dominant Alzheimer's disease
National Institutes of Health
Grant: 1RF1AG062479-01
The complex interaction between Alzheimer drivers and aging
National Institutes of Health
Grant: 1RM1NS132996-01
Resilience to Cognitive Decline and Resistance to Alzheimer's Disease and Related Neurodegenerative Diseases in Individuals from Colombia with Autosomal Dominant Dementias
National Institutes of Health
Grant: 5R01AG054671-03
Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's disease
Alzheimer's Association, and the Massachusetts General Hospital Executive Committee on Research
Tau Consortium
FWCI
1.10
Citation Percentile
0.8%
Citation Trend
Fields of Study
MeSH Terms
Keywords
Sustainable Development Goals