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Genome‐wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease

Alzheimer s & Dementia(2025)10.1002/alz.70198Source: DataRank Database

Genome‐wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease is a research paper published in Alzheimer s & Dementia (2025). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Enrichment:Funding (48 grants)Impact (FWCI 5.38)OA: hybridTopics (59)IDs (PubMed, PMC, OpenAlex)Annotations (3)

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Accessible (1/2)

Open Access

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Reusable (0/3)

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Authors (19)

Michael G. Heckman ORCID,Fabienne C. Fiesel ORCID,Shunsuke Koga ORCID,Alexandra I. Soto‐Beasley ORCID,Jens O. Watzlawik ORCID

Live enrichment

PubMed:40309932 PMC:PMC12044520 OpenAlex:https://openalex.org/W4410005010

National Institute of Neurological Disorders and Stroke

Grant: U54NS110435

National Institute of Neurological Disorders and Stroke

Grant: RF1NS085070

National Institute of Neurological Disorders and Stroke

Grant: R01NS110085

National Institute of Neurological Disorders and Stroke

Grant: P50NS072187

National Institute of Neurological Disorders and Stroke

Grant: R01NS078086

National Institute of Neurological Disorders and Stroke

Grant: U01NS100620

National Institute of Neurological Disorders and Stroke

Grant: U54NS100693

National Institute on Aging

Grant: P30AG062677

National Institute on Aging

Grant: R56AG062556

National Institute on Aging

Grant: U19AG071754

National Institute on Aging

Grant: R01AG056366

National Institute on Aging

Grant: R01AG087165

National Institute on Aging

Grant: R01AG089380

National Institute on Aging

Grant: U19AG069701

National Institute on Aging

Grant: RF1AG046205

Congressionally Directed Medical Research Programs

Grant: W81XWH‐17‐1‐0248

Congressionally Directed Medical Research Programs

Grant: W81XWH‐17‐1‐0249

Alzheimer's Association

Grant: AARF‐22‐973152

Florida Department of Health-Ed, Ethel Moore Alzheimer's Disease Research Program

Grant: 22A05

Congressionally Directed Medical Research Programs

Grant: W81XWH-17-1-0249

Alzheimer's Association

Grant: AARF-22-973152

Florida Department of Health-Ed, Ethel Moore Alzheimer's Disease Research Program

Grant: 22A07

Congressionally Directed Medical Research Programs

Grant: W81XWH-17-1-0248

National Institutes of Health

Grant: 1R01AG089380-01

Bio-RaPID: Biomarkers and Rates of Progression In Dementia.

National Institutes of Health

Grant: 5U54NS100693-02

Identifying genes and Pathways that impact Tau Toxicity in FTD

National Institutes of Health

Grant: 5P30AG062677-02

Mayo Alzheimer's Disease Research Center

National Institutes of Health

Grant: 5R01AG056366-04

Exceptional Aging: Identifying Modifiers of Alzheimer's Disease Trajectories

National Institutes of Health

Grant: 2RF1AG046205-06

ApoE isoform-specific therapy for Alzheimer disease

National Institutes of Health

Grant: 4R01NS078086-05

Understanding the role of MAPT in Parkinsonian disorders

National Institutes of Health

Grant: 1R56AG062556-01

Selective autophagy in Alzheimer's disease and related dementias

National Institutes of Health

Grant: 5U54NS110435-02

Synergistic Interaction of amyloid-beta and alpha-synuclein in Lewy body Dementia

National Institutes of Health

Grant: 2RF1NS085070-06

Molecular mechanisms of PINK1-PRKN directed mitochondrial quality control

National Institutes of Health

Grant: 1R01NS110085-01A1

Mitochondrial Sirtuin 3 in Parkinson's disease

National Institutes of Health

Grant: 5U01NS100620-09

Longitudinal Imaging Biomarkers of Prodromal DLB

National Institutes of Health

Grant: 5P50NS072187-04

Identification of novel Parkinsonian genes by wholegenome

National Institutes of Health

Grant: 1U19AG069701-01

Biology and pathobiology of apoE in aging and Alzheimer's disease

National Institutes of Health

Grant: 1U19AG071754-01

North American Prodromal Synucleinopathy Consortium for RBD, Stage 2 (NAPS2)

National Institutes of Health

Grant: 1R01AG087165-01

Elucidating the Pathomechanisms of APOE4 in Lewy Body Dementia

Mangurian Foundation Lewy Body Dementia Program at Mayo Clinic

Ted Turner and Family

American Parkinson Disease Association Center for Advanced Research at Mayo Clinic Jacksonville

The Ted Nash Long Life Foundation

American Brain Foundation

Mayo Clinic Robert and Arlene Kogod Center on Aging

The Little Family Foundation

Mayo Clinic Center for Biomedical Discovery

The Michael J. Fox Foundation for Parkinson's Research

Mayo Clinic Office of Research Equity, Inclusion, and Diversity

FWCI

5.38

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70198

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70198

publisherhttps://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.70198

journalhttps://doi.org/10.1002/alz.70198

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40309932

Fields of Study

Autophagy in Disease and TherapyMitochondrial Function and PathologyLysosomal Storage Disorders Research

MeSH Terms

AgedAged, 80 and overAnimalsApolipoproteins EBrainFemaleHumansMaleMitochondriaPolymorphism, Single NucleotideLewy Body DiseaseUbiquitinMiceApolipoprotein E4Genome-Wide Association StudyInduced Pluripotent Stem CellsMitophagy

Keywords

MitophagyLewy bodyDiseaseAssociation (psychology)Apolipoprotein EGenetic associationBiologyGenome-wide association studyGeneticsParkinson's diseaseAutophagyMedicinePsychologyGenePathologyGenotypeSingle-nucleotide polymorphismMitochondriaUbiquitinParkinGwasPink1PrknZmiz1Phosphorylated UbiquitinLewy Body DiseaseMaleAged, 80 and overApolipoprotein E4Induced Pluripotent Stem CellsBrainPolymorphism, Single NucleotideMiceApolipoproteins EHumansAnimalsFemaleResearch ArticleAged

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