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Inhibition of the GSK3β/Nav1.6 complex suppresses early‐stage Alzheimer's hyperexcitability

Alzheimer s & Dementia(2025)10.1002/alz.70507Source: DataRank Database

Inhibition of the GSK3β/Nav1.6 complex suppresses early‐stage Alzheimer's hyperexcitability is a research paper published in Alzheimer s & Dementia (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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Enrichment:Funding (22 grants)OA: hybridTopics (39)IDs (PubMed, PMC)Annotations (3)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (23)

Manuel Silva‐Pérez ORCID,Zahra Haghighijoo ORCID,Nolan M. Dvorak ORCID,A.K. Singh ORCID,Nana A. Goode

Live enrichment

PubMed:40717647 PMC:PMC12301699

National Institutes of Health

Grant: R01AG065290

National Institutes of Health

Grant: R01AG070255

National Institutes of Health

Grant: R01MH12351

National Institutes of Health

Grant: R01MH132226

National Institute of Environmental Health Sciences

Grant: P30ES030285

Cancer Prevention and Research Institute of Texas

Grant: RP170719

Moody Brain Health Institute at the University of Texas

Grant: BHI2024-13

Dan Duncan Digestive Disease Center

Grant: DK056338

NCI NIH HHS

Grant: P30 CA125123

National Institute of Aging

Grant: T32AG067952-01

Moody Brain Health Institute Pilot Project

Grant: P87462

NIH HHS

Grant: S10 OD032293

Houston Area Molecular Biophysics Program

Grant: T32GM008280

National Institutes of Health

Grant: 3T32GM008280-27S1

Houston Area Molecular Biophysics Program

National Institutes of Health

Grant: 1F30MH012351-01A2

CHOLINERGIC INFLUENCE ON CIRCADIAN FUNCTION

National Institutes of Health

Grant: 5T32AG067952-05

Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology

National Institutes of Health

Grant: 5R01AG065290-02

Thalamic Reticular Nucleus Dysfunction in Alzheimer's Disease

National Institutes of Health

Grant: 3P30CA125123-09S3

Baylor College of Medicine Cancer Center

National Institutes of Health

Grant: 1R01MH132226-01

Probing brain circuit and behavior with protein:protein interaction modulators

National Institutes of Health

Grant: 3P30ES030285-03S1

Administrative Supplement for Gulf Coast Center for Precision Environmental Health

National Institutes of Health

Grant: 5R01AG070255-02

Mechanisms of Synaptic Protection in Cognitive Resilence to Alzheimer's Disease Neuropathology

American Epilepsy Society

hybridLicense: cc-by-nc-nd

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70507

publisherhttps://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.70507

publisherhttps://alz-journals.onlinelibrary.wiley.com/doi/full-xml/10.1002/alz.70507

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12301699

Europe_PMChttps://europepmc.org/articles/PMC12301699

Fields of Study

03 medical and health sciences0302 clinical medicine

MeSH Terms

NeuronsAnimalsMice, TransgenicHumansMiceAlzheimer DiseaseDisease Models, AnimalElectroencephalographyPatch-Clamp TechniquesAction PotentialsMaleAmyloid beta-PeptidesNAV1.6 Voltage-Gated Sodium ChannelGlycogen Synthase Kinase 3 beta

Keywords

Alzheimer's diseaseGlycogen Synthase Kinase 3βNeuronal HyperexcitabilityNav1.6Small Molecule Drug DiscoveryVoltage‐gated Sodium ChannelAmyloid Beta‐induced HyperexcitabilityNetwork HyperactivityNeuronsMaleGlycogen Synthase Kinase 3 betaPatch-Clamp TechniquesAmyloid beta-PeptidesAction PotentialsMice, TransgenicElectroencephalographyDisease Models, AnimalMiceAlzheimer DiseaseNAV1.6 Voltage-Gated Sodium ChannelAnimalsHumansResearch Article

Inhibition of the GSK3β/Nav1.6 complex suppresses early‐stage Alzheimer's hyperexcitability

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Authors (23)

Funding (22 grants)

Open Access

Topics

Annotations (Europe PMC)