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Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microglia

Alzheimer s & Dementia(2025)10.1002/alz.70879Source: DataRank Database

Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microglia is a research paper published in Alzheimer s & Dementia (2025). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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Enrichment:Funding (6 grants)OA: hybridTopics (20)IDs (PubMed, PMC)Annotations (1)

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Open Access

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Authors (4)

Anna Maaser‐Hecker,Jun‐Seok Bae,Rudolph E. Tanzi ORCID,Moriah J. Hovde ORCID

Live enrichment

PubMed:41216966 PMC:PMC12603916

Cure Alzheimer's Fund

Grant: T32 AG000222‐31

National Institute on Aging

Grant: T32AG000222

Cure Alzheimer's Fund

Grant: T32 AG000222-31

NIH

Freedom Together Fund

National Institutes of Health

hybridLicense: cc-by-nc-nd

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70879

publisherhttps://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.70879

publisherhttps://alz-journals.onlinelibrary.wiley.com/doi/full-xml/10.1002/alz.70879

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12603916/pdf/ALZ-21-e70879.pdf

Europe_PMChttps://europepmc.org/articles/PMC12603916

MeSH Terms

MicrogliaAnimalsMice, KnockoutHumansMiceAcetyl-CoA C-AcetyltransferaseSterol O-AcyltransferaseMembrane GlycoproteinsReceptors, ImmunologicPhagocytosisAmyloid beta-PeptidesLow Density Lipoprotein Receptor-Related Protein-1

Keywords

PhagocytosisAlzheimer's diseaseAmyloid betaMicroglialipid dropletsLrp1Trem2Acat1/soat1

Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microglia

FAIR Checklist

Authors (4)

Funding (6 grants)

Open Access

Topics

Annotations (Europe PMC)