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Adaptive Bayesian phase I clinical trial designs for estimating the maximum tolerated doses for two drugs while fully utilizing all toxicity information

Biometrical Journal(2021)10.1002/bimj.202000142Source: DataRank Database

Adaptive Bayesian phase I clinical trial designs for estimating the maximum tolerated doses for two drugs while fully utilizing all toxicity information is a research paper published in Biometrical Journal (2021). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Enrichment:Funding (2 grants)OA: greenTopics (18)IDs (PubMed)SDGs (1)

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Authors (3)

Michael Kutner ORCID,Zhengjia Chen ORCID,Yuzi Zhang ORCID

Live enrichment

PubMed:26657633

National Institutes of Health

Grant: 1P50CA217691-01A1

Emory University Lung Cancer SPORE

National Institutes of Health

Grant: 3P01CA116676-05S1

Targeting Cell Signaling in lung cancer to enhance therapeutic efficacy

greenLicense: Wiley Online Library User Agreement

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10066875/pdf/nihms-1867114.pdf

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/bimj.202000142

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.1002/bimj.202000142

https://doi.org/10.1002/bimj.202000142

https://pubmed.ncbi.nlm.nih.gov/33969525

Fields of Study

01 natural sciences0101 mathematics

Keywords

Clinical Trials as TopicDose-Response Relationship, DrugMaximum Tolerated Dosemaximum tolerated dose curvequasi-continuous toxicity responsedrug combinationAntineoplastic AgentsBayes TheoremApplications of statistics to biology and medical sciences; meta analysisDrug CombinationsResearch DesignNeoplasmscancer phase I clinical trialHumansComputer Simulationescalation with overdose control

Sustainable Development Goals

SDG 3: 3. Good health