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A New Methodology for Incorporating Chiral Linkers into Stapled Peptides

ChemBioChem(2017)10.1002/cbic.201700075Source: DataRank Database

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides is a research paper published in ChemBioChem (2017). On theSindex it has a DataRank of 1.1. It has been cited 23 times, with 21 citing works in its 1-hop citation network.

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1.1DataRank · unranked

Scored on demand from live citation data

23 citations · 21 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)OA: hybridTopics (50)IDs (PubMed, PMC)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 42%Citation Network 58%

Base Score Contribution

0.477

From this paper's citation signal

Citation Network Contribution

0.656

From 20 citing papers with measurable signal

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Authors (5)

James Sipthorp ORCID,Wenshu Xu,Laura S. Itzhaki ORCID,Steven V. Ley ORCID,Juan C. Serrano ORCID

Live enrichment

PubMed:28388005 PMC:PMC5488175

Engineering and Physical Sciences Research Council

Grant: EP/K009494/1

Fully-Integrated Continuous Flow Processes for Access to Forbidden Chemistries, New Reactivities and Sequential Complexity Generation

Engineering and Physical Sciences Research Council

Grant: EP/M004120/1

Development of Automated Parallel CO2 Supercritical Fluid Chromatography for Use in Continuous Flow Chemical Synthesis

Engineering and Physical Sciences Research Council

Grant: EP/K/039520/1

Medical Research Council

Grant: G1002329

Defining the Mechanisms Underlying Tandem Repeat Protein Functions

MRF_

Grant: C0385

Medical Research Council

Grant: MC_PC_14116

Cancer Research UK

Grant: 22676

Medical Research Council

Grant: MC_PC_13059

Engineering and Physical Sciences Research Council

Grant: EP/K039520/1

Gates Cambridge Trust

hybridLicense: cc-by

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.201700075

publisherhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbic.201700075

publisherhttps://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.201700075

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/5488175

Europe_PMChttps://europepmc.org/articles/PMC5488175

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Cell Line, TumorHumansBenzhydryl CompoundsAlaninePeptidesPeptide LibraryCross-Linking ReagentsProtein Structure, SecondaryProtein BindingTumor Suppressor Protein p53Proto-Oncogene Proteins c-mdm2Protein StabilitySolid-Phase Synthesis Techniques

Keywords

solid-phase synthesisprotein-protein interactionsStapled PeptidesTwo-component StaplingChiral LinkersP53 PeptideBiochemistry & Molecular BiologyDesignMetathesisTarget Binding-AffinityMedicinalPermeabilityProtein Structure, SecondaryPeptide LibraryCell Line, TumorHumansPharmacology & PharmacyBenzhydryl CompoundsSolid-Phase Synthesis TechniquesScience & TechnologyAlanineInhibitorsProtein StabilityProto-Oncogene Proteins c-mdm2Alpha-Helical PeptidesCommunicationsChemistryCross-Linking ReagentsStrategiesNetworksTumor Suppressor Protein p53PeptidesLife Sciences & BiomedicineProtein Binding