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N‐Glycosylation‐Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules

Chemistry - A European Journal(2024)10.1002/chem.202401957Source: DataRank Database

N‐Glycosylation‐Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules is a research paper published in Chemistry - A European Journal (2024). On theSindex it has a DataRank of 0. It has been cited 9 times.

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Open Access9 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (25 grants)Impact (FWCI 1.44)OA: hybridTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Cristiano Sciva,Matteo Castelli ORCID,Chander Singh Digwal ORCID,Anna Rodina,Sahil Sharma ORCID

Live enrichment

PubMed:39042517 PMC:PMC12000882 OpenAlex:https://openalex.org/W4400913849

National Institutes of Health

Grant: R01 CA172546, P01 CA186866, R56 AG061869, RF1 AG071805, R01 AG067598, R01 AG074004, R01 AG072599, P30 CA08748

Fondazione AIRC per la ricerca sul cancro ETS

Grant: IG 2022 - ID. 27139

Ministero della Salute

Grant: IMMUNO-HUB, T4-CN-02,

Ministero dell'Università e della Ricerca

Grant: Programma di ricerca CN00000013

NIA NIH HHS

Grant: R01 AG067598

NIA NIH HHS

Grant: R01 AG072599

NIA NIH HHS

Grant: RF1 AG071805

NIA NIH HHS

Grant: R01 AG085572

NIAID NIH HHS

Grant: R21 AI090501

NIA NIH HHS

Grant: R56 AG072599

NIA NIH HHS

Grant: R01 AG074004

NCI NIH HHS

Grant: R01 CA172546

NCI NIH HHS

Grant: P30 CA008748

NCI NIH HHS

Grant: P01 CA186866

NIA NIH HHS

Grant: R56 AG061869

NIA NIH HHS

Grant: U01 AG032969

NCI NIH HHS

Grant: R21 CA158609

National Institutes of Health

Grant: 1R01AG072599-01A1

Selective interactome vulnerability across the Alzheimer’s disease spectrum

National Institutes of Health

Grant: 1R56AG061869-01

A chemical chaperomics platform for AD

National Institutes of Health

Grant: 5R01CA172546-05

Biomarkers for predicting response to Hsp90 therapy

National Institutes of Health

Grant: 5R01AG074004-04

Impact of sex differences on the trajectory of interactome dysfunctions across the AD spectrum

National Institutes of Health

Grant: 5P01CA186866-02

Endoplasmic Reticulum Chaperones in Cancer Biology and Therapy

National Institutes of Health

Grant: 2P30CA008748-43

MOUSE GENETICS

National Institutes of Health

Grant: 3RF1AG071805-02S1

[18F]-PU-AD epichaperome PET imaging probe

National Institutes of Health

Grant: 5R01AG067598-04

Chaperome networks in Alzheimer's disease

FWCI

1.44

Citation Percentile

0.8%

Citation Trend

2025

2026

hybridLicense: cc-by-nc

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.202401957

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.202401957

publisherhttps://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202401957

journalhttps://doi.org/10.1002/chem.202401957

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39042517

Fields of Study

Heat shock proteins researchGlycosylation and Glycoproteins ResearchToxin Mechanisms and Immunotoxins01 natural sciences0104 chemical sciences0103 physical sciencesGlycosylationLigandsMolecular Dynamics SimulationHumansProtein ConformationBinding SitesProtein Processing, Post-TranslationalQuantitative Structure-Activity RelationshipSmall Molecule LibrariesMembrane Glycoproteins

MeSH Terms

Binding SitesGlycosylationHumansLigandsMembrane GlycoproteinsProtein ConformationProtein Processing, Post-TranslationalQuantitative Structure-Activity RelationshipSmall Molecule LibrariesMolecular Dynamics Simulation

Keywords

GlycosylationSelection (genetic algorithm)Biological activitySmall moleculeComputational biologyChemistryBiochemistryBiologyComputer scienceIn vitroArtificial intelligenceDrug designPost-translational modificationsMolecular dynamicsChaperones570Binding SitesMembrane GlycoproteinsProtein ConformationQuantitative Structure-Activity RelationshipMolecular Dynamics Simulation540LigandsArticleSmall Molecule LibrariesHumansProtein Processing, Post-Translational

Sustainable Development Goals

SDG 0: Industry, innovation and infrastructure