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Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

Chemistry - A European Journal(2025)10.1002/chem.202500306Source: DataRank Database

Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I is a research paper published in Chemistry - A European Journal (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.97)OA: greenTopics (19)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Rania Omer,Fumitoshi Sugino,Nanami Ogino,Yoshihisa Inoue ORCID,Aslamuzzaman Kazi ORCID

Live enrichment

PubMed:40200839 OpenAlex:https://openalex.org/W4409303331

Japan Society for the Promotion of Science

Grant: 21H02077

Japan Society for the Promotion of Science

Grant: 20K21248

Japan Society for the Promotion of Science

Grant: 18H02106

National Institutes of Health

Grant: R35CA197731‐01

FWCI

0.97

Citation Percentile

0.7%

Citation Trend

2025

2026

greenLicense: other-oa

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12080315

publisherhttps://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202500306

journalhttps://doi.org/10.1002/chem.202500306

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40200839

Fields of Study

Protein Kinase Regulation and GTPase SignalingPeptidase Inhibition and AnalysisMelanoma and MAPK Pathways

MeSH Terms

Binding SitesEnzyme InhibitorsHumansDrug DesignProto-Oncogene Proteins p21(ras)Alkyl and Aryl TransferasesCell Line, TumorFarnesyltranstransferase

Keywords

FarnesyltransferaseGeranylgeranylationPrenylationFarnesyltransferase inhibitorChemistryBiochemistryStereochemistryEnzyme

Sustainable Development Goals

SDG 0: Good health and well-being