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Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders

ChemMedChem(2025)10.1002/cmdc.202500209Source: DataRank Database

Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders is a research paper published in ChemMedChem (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (6 grants)Impact (FWCI 0.00)OA: hybridTopics (40)IDs (PubMed, PMC, OpenAlex)

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Findable (1/2)

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Accessible (1/2)

Open Access

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Reusable (0/3)

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Authors (6)

Ira Tandon ORCID,Ramesh Mudududdla ORCID,Paulina N. Esguerra,Kevin Lucio‐Acero,Weiping Tang ORCID

Live enrichment

PubMed:40963416 PMC:PMC12471865 OpenAlex:https://openalex.org/W4414305935

Wisconsin Alumni Research Foundation

Grant: UW2020

National Institutes of Health

Grant: R35GM148266

Lachman Institute for Pharmaceutical Development and UW Carbone Cancer Center

Grant: NIH P30 CA014520

NIGMS NIH HHS

Grant: T32 GM152341

NCI NIH HHS

Grant: P30 CA014520

NIGMS NIH HHS

Grant: T32 GM141013

FWCI

0.00

Citation Percentile

0.2%

hybridLicense: cc-by

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cmdc.202500209

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cmdc.202500209

publisherhttps://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202500209

journalhttps://doi.org/10.1002/cmdc.202500209

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40963416

Fields of Study

Protein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsPeptidase Inhibition and AnalysisHumansAgammaglobulinaemia Tyrosine KinaseProteolysisLigandsUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingStructure-Activity RelationshipSmall Molecule LibrariesMolecular StructureProtein Kinase InhibitorsDose-Response Relationship, DrugAntineoplastic AgentsProteolysis Targeting Chimera

MeSH Terms

Agammaglobulinaemia Tyrosine KinaseProteolysis Targeting ChimeraAntineoplastic AgentsDose-Response Relationship, DrugHumansLigandsStructure-Activity RelationshipMolecular StructureUbiquitin-Protein LigasesProtein Kinase InhibitorsAdaptor Proteins, Signal TransducingSmall Molecule LibrariesProteolysis

Keywords

CereblonUbiquitin ligaseBruton's tyrosine kinaseDNA ligaseTyrosine kinaseProteolysisUbiquitinTyrosineChimera (genetics)Achiral LigandsProteolysis Targeting Chimeras