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Potent, Selective, and Drug‐Like G Protein‐Coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X‐Ray Structural Studies

ChemMedChem(2025)10.1002/cmdc.202500257Source: DataRank Database

Potent, Selective, and Drug‐Like G Protein‐Coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X‐Ray Structural Studies is a research paper published in ChemMedChem (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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Enrichment:Funding (9 grants)OA: hybridTopics (18)IDs (PubMed, PMC)Annotations (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Ranjith Kumar Gadi,Yueyi Chen ORCID,Sandali Piladuwa Gamage,Kathryn P. McCauley,J.J.G. Tesmer ORCID

Live enrichment

PubMed:40388590 PMC:PMC12530842

NIH

Grant: HL071818

NIH

Grant: P30CA023168

NHLBI NIH HHS

Grant: R01 HL071818

NMR

Purdue University

WCF

Walther Cancer Foundation

Paula and Rodger Riney Foundation

hybridLicense: cc-by

publisherhttps://doi.org/10.1002/cmdc.202500257

publisherhttps://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202500257

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12530842

Europe_PMChttps://europepmc.org/articles/PMC12530842

Europe_PMChttps://europepmc.org/articles/PMC12530842?pdf=render

MeSH Terms

HumansIndolesProtein Kinase InhibitorsCrystallography, X-RayMolecular StructureCatalytic DomainStructure-Activity RelationshipDrug DesignModels, MolecularG-Protein-Coupled Receptor KinasesG-Protein-Coupled Receptor Kinase 5

Keywords

SelectivityGrk2HeterocyclicSunitinibGrk5 InhibitorsX‐ray Crystal StructuresGrk6 Inhibitors