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Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D 4 R) Antagonist in vitro Tool compounds

ChemMedChem(2025)10.1002/cmdc.202500298Source: DataRank Database

Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D 4 R) Antagonist in vitro Tool compounds is a research paper published in ChemMedChem (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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Enrichment:Funding (1 grants)Impact (FWCI 0.78)OA: bronzeTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Sumaiya Nahid ORCID,Anish K. Vadukoot ORCID,Corey R. Hopkins ORCID,Saeedeh Saeedi ORCID

Live enrichment

PubMed:40440467 PMC:PMC12321283 OpenAlex:https://openalex.org/W4410841818

National Institute of Neurological Disorders and Stroke

Grant: R01NS119266

FWCI

0.78

Citation Percentile

0.7%

Citation Trend

2026

bronzeLicense: http://creativecommons.org/licenses/by-nc-nd/4.0/

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cmdc.202500298

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cmdc.202500298

publisherhttps://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202500298

journalhttps://doi.org/10.1002/cmdc.202500298

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40440467

Fields of Study

Computational Drug Discovery MethodsCholinesterase and Neurodegenerative DiseasesReceptor Mechanisms and Signaling

MeSH Terms

AnimalsHumansMicrosomes, LiverPiperidinesStructure-Activity RelationshipMolecular StructureDopamine AntagonistsReceptors, Dopamine D4

Keywords

AntagonistIn vitroPiperidineScaffoldChemistryDopamineReceptor antagonistPharmacologyReceptorStereochemistryBiochemistryBiologyNeuroscienceMedicineBiomedical engineeringAntagonistsDifluoropiperidineDopamine 4 ReceptorsIn vitro Pk

Sustainable Development Goals

SDG 0: No poverty