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Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem(2025)10.1002/cmdc.202500507Source: DataRank Database

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential is a research paper published in ChemMedChem (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (9 grants)Impact (FWCI 0.00)OA: hybridTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Moustafa E. El‐Araby,Tarek A. Ahmed ORCID,Akua K. Donkor ORCID,Albert Opare,Mohini S. Ghatge ORCID

Live enrichment

PubMed:41070786 PMC:PMC12640667 OpenAlex:https://openalex.org/W4415026988

Institutional Fund Projects

Grant: IFPNC-002-166-2020

NIH Shared Instrumentation

Grant: S10OD021756

NHLBI NIH HHS

Grant: R61 HL156158

Ministry of Education and King Abdulaziz University, Jeddah, Saudi Arabia

Virginia Commonwealth University (MKS)

Virginia General Assembly Higher Education Equipment Trust Fund (HEETF)

Virginia Commonwealth University (MKS)

Ministry of Education and King Abdulaziz University, Jeddah, Saudi Arabia

Virginia General Assembly Higher Education Equipment Trust Fund (HEETF)

FWCI

0.00

Citation Percentile

0.4%

hybridLicense: cc-by-nc-nd

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cmdc.202500507

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cmdc.202500507

publisherhttps://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202500507

journalhttps://doi.org/10.1002/cmdc.202500507

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41070786

Fields of Study

Hemoglobinopathies and Related DisordersIron Metabolism and DisordersErythrocyte Function and PathophysiologyAnemia, Sickle CellHumansAntisickling AgentsStructure-Activity RelationshipAnimalsMolecular StructureCrystallography, X-RayAldehydesDose-Response Relationship, DrugAdministration, Intravenous

MeSH Terms

AldehydesAnemia, Sickle CellAnimalsAntisickling AgentsDose-Response Relationship, DrugHumansStructure-Activity RelationshipMolecular StructureCrystallography, X-RayAdministration, Intravenous

Keywords

PotencyPharmacodynamicsDrugHemoglobinIn vitroRed blood cellPolyethylene glycolWhole bloodSickle Cell DiseaseAntisicklingAromatic AldehydesX‐ray Crystallography5‐Hmf AnalogsAcute Crises

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

FAIR Checklist

Authors (16)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)