Quantitative mapping of tryptophan hydroxylase‐2, 5‐HT<sub>1A</sub>, 5‐HT<sub>1B</sub>, and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei is a research paper published in Journal of Comparative Neurology (2006). On theSindex it has a DataRank of 2.5. It has been cited 67 times, with 59 citing works in its 1-hop citation network.
AbstractDepression and anxiety disorders are among the leading causes of morbidity, mortality, and disability in the United States. Impaired serotonin neurotransmission appears to be a central mechanism inducing depressive and anxiety symptoms. Most serotonergic innervation of the forebrain arises from the median raphe nucleus (MRN) and dorsal raphe nucleus (DRN). The DRN displays a complex internal morphology, with distinct subregions varying across the anteroposterior (A‐P) axis. However, many studies have considered the DRN as a whole or used easily confused terminology to describe position. Given the large differences in receptor expression, electrophysiological properties, and connectivity between various subregions of the DRN, it appears probable that they have distinct functional roles in the regulation of behavior. To foster uniform definitions of locations within these nuclei, we have quantitatively mapped gene expression in DRN and MRN for tryptophan hydroxylase‐2 (Tph2), the serotonin transporter, as well as 5‐HT1A and 5‐HT1B receptors. These quantitative studies revealed differences in the density of expression of each gene in the ventromedial, dorsomedial, and dorsolateral subnuclei of the DRN, as well as distinct variation in expression across the A‐P axis. These findings provide additional evidence that subregions of the DRN are heterogeneous and need to be considered independently. In addition, a fine scale map of Tph2 expression suggests definitions for categorical divisions of the DRN across the A‐P axis. These are based on distinct morphological patterns of Tph2 expression and may be more reflective of physiology than the classic terminology dividing the DRN into equal thirds. J. Comp. Neurol. 498:611–623, 2006. © 2006 Wiley‐Liss, Inc.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.633
From this paper's citation signal
Citation Network Contribution
1.9
From 55 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 25% comes from its base citations and 75% from the citation network (55 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
Click a node to highlight its connections. Use scroll to zoom. Drag to pan.