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Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype

Comprehensive physiology(2025)10.1002/cph4.70011Source: DataRank Database

Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype is a research paper published in Comprehensive physiology (2025). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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Enrichment:Funding (20 grants)Impact (FWCI 7.34)OA: hybridTopics (47)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

François Potus ORCID,Ruaa Al‐Qazazi ORCID,Benjamin P. Ott,William C. Nichols ORCID,Michael J. Rauh ORCID

Live enrichment

PubMed:40274312 PMC:PMC12021535 OpenAlex:https://openalex.org/W4409742532

Canada Foundation for Innovation

Grant: 229252

Canada Foundation for Innovation

Grant: 33012

National Institutes of Health

Grant: R01‐HL071115

National Institutes of Health

Grant: 1RC1HL099462

National Institutes of Health

Grant: R24‐HL105333

National Institutes of Health

Grant: R01‐HL160941

NIH HHS

Grant: R01-HL071115

NIH HHS

Grant: R24-HL105333

NIH HHS

Grant: R01-HL160941

NHLBI NIH HHS

Grant: R01 HL113003

NHLBI NIH HHS

Grant: RC1 HL099462

Canadian Institutes of Health Research

William M. Spear Endowment Fund in Pulmonary Research

CIHR

Richard K. Start Memorial Fund

William J Henderson Foundation

CIHR

William J Henderson Foundation

Richard K. Start Memorial Fund

William M. Spear Endowment Fund in Pulmonary Research

FWCI

7.34

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1002/cph4.70011

publisherhttps://doi.org/10.1002/cph4.70011

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/cph4.70011

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40274312

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12021535

Fields of Study

Pulmonary Hypertension Research and TreatmentsEosinophilic Disorders and SyndromesHumansDioxygenasesDNA MethylationFemaleMaleProto-Oncogene ProteinsMutationMiddle AgedPulmonary Arterial HypertensionDNA-Binding ProteinsT-LymphocytesAdultEpigenesis, GeneticAged

MeSH Terms

Pulmonary Arterial HypertensionAdultAgedDNA-Binding ProteinsFemaleHumansMaleMiddle AgedMutationProto-Oncogene ProteinsT-LymphocytesDNA MethylationEpigenesis, GeneticDioxygenases

Keywords

DNA methylationEpigeneticsBiologyMethylationMutationMolecular biologyGeneticsEpigenomicsGeneCpG siteCancer researchGene expressionMetabolismEpigeneticT Cell DifferentiationReduced Representation Bisulfite Sequencing (Rrbs)Transcription Factor 7 (Tcf7)

Sustainable Development Goals

SDG 0: Good health and well-being