Fgfr signaling is required as the early eye field forms to promote later patterning and morphogenesis of the eye is a research paper published in Developmental Dynamics (2014). On theSindex it has a DataRank of 0.684. It has been cited 16 times, with 14 citing works in its 1-hop citation network.
Background: A major step in eye morphogenesis is the transition from optic vesicle to optic cup, which occurs as a ventral groove forms along the base of the optic vesicle. A ventral gap in the eye, or coloboma, results when this groove fails to close. Extrinsic signals, such as fibroblast growth factors (Fgfs), play a critical role in the development and morphogenesis of the vertebrate eye. Whether these extrinsic signals are required throughout eye development, or within a defined critical period remains an unanswered question. Results: Here we show that an early Fgf signal, required as the eye field is first emerging, drives eye morphogenesis. In addition to triggering coloboma, inhibition of this early Fgf signal results in defects in dorsal‐ventral patterning of the neural retina, particularly in the nasal retina, and development of the periocular mesenchyme (POM). These processes are unaffected by inhibition of Fgfr signaling at later time points. Conclusions: We propose that Fgfs act within an early critical period as the eye field forms to promote development of the neural retina and POM, which subsequently drive eye morphogenesis. Developmental Dynamics 243:663–675, 2014. © 2014 Wiley Periodicals, Inc.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.425
From this paper's citation signal
Citation Network Contribution
0.259
From 14 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 62% comes from its base citations and 38% from the citation network (14 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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