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CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma

Head & Neck(2025)10.1002/hed.70048Source: DataRank Database

CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma is a research paper published in Head & Neck (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (11 grants)Impact (FWCI 0.00)OA: hybridTopics (37)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Megan Ludwig ORCID,Aditi Kulkarni ORCID,Andrew C. Birkeland ORCID,Nicole L. Michmerhuizen ORCID,Elizabeth Gensterblum‐Miller ORCID

Live enrichment

PubMed:40985049 PMC:PMC12797014 OpenAlex:https://openalex.org/W4414440763

National Institutes of Health

Grant: U01DE025184

National Institutes of Health

Grant: P30‐CA046592

American Cancer Society

Grant: R01DE032699

American Cancer Society

Grant: T32GM145470

National Institute of Dental and Craniofacial Research

Grant: F31 CA206341‐03

National Science Foundation

Grant: DGE‐1256260

NIDCR NIH HHS

Grant: F31 CA206341-03

NCI NIH HHS

Grant: F31 CA206341

NIH HHS

Grant: P30-CA046592

National Science Foundation

Grant: DGE-1256260

NCI NIH HHS

Grant: P30 CA046592

FWCI

0.00

Citation Percentile

0.2%

hybridLicense: cc-by

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hed.70048

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hed.70048

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.70048

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.1002/hed.70048

journalhttps://doi.org/10.1002/hed.70048

Fields of Study

PI3K/AKT/mTOR signaling in cancerCancer-related Molecular PathwaysHead and Neck Cancer StudiesHumansDrug Resistance, NeoplasmErbB ReceptorsSquamous Cell Carcinoma of Head and NeckCell Line, TumorHead and Neck NeoplasmsPhosphatidylinositol 3-KinasesApoptosisClustered Regularly Interspaced Short Palindromic RepeatsProtein Kinase InhibitorsAntineoplastic Agents

MeSH Terms

Squamous Cell Carcinoma of Head and NeckAntineoplastic AgentsHead and Neck NeoplasmsHumansApoptosisDrug Resistance, NeoplasmPhosphatidylinositol 3-KinasesCell Line, TumorProtein Kinase InhibitorsClustered Regularly Interspaced Short Palindromic RepeatsErbB Receptors

Keywords

MediatorHead and neck squamous-cell carcinomaHead and neckAcquired resistanceEGFR inhibitorsBasal cellEpidermoid carcinomaDrug resistanceCrisprEgfr InhibitorHnsccPik3c2a